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Research Roundup: June 27, 2022

Best of cannabinoid science this week...

In humans with COVID-19, PEA reduced inflammatory markers & may reduce the severity of the disease Effects of Palmitoylethanolamide on Proinflammatory Markers in Adults Recently Diagnosed With COVID-19 In humans with pelvic pain, a combination of PEA & magnesium reduced pain & increased quality of life A Palmitoylethanolamide (PEA) and Magnesium Based Product (PEAMag) Reduces the Pain and Improves Quality of Life in Patients Affected by Acute and Chronic Pelvic Pain A case report of using CBD for a severe epilepsy that caused this 3-year-old to be seizure free for 16 months Cannabidiol Successful Therapy for Developmental and Epileptic Encephalopathy Related to CYFIP2 A review of the evidence suggests the promising benefits of cannabis for migraine Medical Cannabis for the Treatment of Migraine in Adults: A Review of the Evidence A review of the use of CBD for sick skin Topical cannabidiol (CBD) in skin pathology - A comprehensive review and prospects for new therapeutic opportunities An editorial on using cannabis & cannabinoids for treating the pain of endometriosis Is it the Ideal Time to Start Prescribing Cannabis Derivatives to Treat Endometriosis-associated Pain? A systematic review on translating the chronic pain research into clinical cannabinoid action Cannabinoids for Chronic Pain: Translating Systematic Review Findings Into Clinical Action In a model of infection by the virus of COVID-19, CBD enhanced the cellular anti-viral response & increased the infected cell’s rate of apoptosis (cellular suicide) Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein A big review of how the endocannabinoid system works with the renin-angiotensin systems (a hormonal system that regulates blood pressure, your balance of fluids & electrolytes, as well as the resistance strength of your circulatory system) & how this might be helpful for treating COVID-19 Cross-Talk between the (Endo)Cannabinoid and Renin-Angiotensin Systems: Basic Evidence and Potential Therapeutic Significance In skin stem cells, UVB radiation causes cell death while the presence of anandamide & CBD protected them from cell death, partially via the COX2 pathway Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids

In mice with kidney injuries, inactivating the FAAH enzyme (something CBD does) protects against scarring via the AEA-COX-2 pathway Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis In prostate cancer cells, when combining with the common treatment cisplatin, CBD worked better than a full cannabis extract The antitumor activity of cannabis sativa and CBD in prostate cancer PC3 cells


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