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Research Roundup: June 27, 2022



Best of cannabinoid science this week...


In humans with COVID-19, PEA reduced inflammatory markers & may reduce the severity of the disease Effects of Palmitoylethanolamide on Proinflammatory Markers in Adults Recently Diagnosed With COVID-19 https://academic.oup.com/cdn/article/6/Supplement_1/200/6606939 In humans with pelvic pain, a combination of PEA & magnesium reduced pain & increased quality of life A Palmitoylethanolamide (PEA) and Magnesium Based Product (PEAMag) Reduces the Pain and Improves Quality of Life in Patients Affected by Acute and Chronic Pelvic Pain http://www.clinicalcasereportsint.com/open-access/a-palmitoylethanolamide-pea-and-magnesium-based-product-peamag-reduces-the-8862.pdf A case report of using CBD for a severe epilepsy that caused this 3-year-old to be seizure free for 16 months Cannabidiol Successful Therapy for Developmental and Epileptic Encephalopathy Related to CYFIP2 https://openneurologyjournal.com/VOLUME/16/ELOCATOR/e1874205X2203290/ABSTRACT A review of the evidence suggests the promising benefits of cannabis for migraine Medical Cannabis for the Treatment of Migraine in Adults: A Review of the Evidence https://pubmed.ncbi.nlm.nih.gov/35711271 A review of the use of CBD for sick skin Topical cannabidiol (CBD) in skin pathology - A comprehensive review and prospects for new therapeutic opportunities https://pubmed.ncbi.nlm.nih.gov/35695447 An editorial on using cannabis & cannabinoids for treating the pain of endometriosis Is it the Ideal Time to Start Prescribing Cannabis Derivatives to Treat Endometriosis-associated Pain? https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1749430 A systematic review on translating the chronic pain research into clinical cannabinoid action Cannabinoids for Chronic Pain: Translating Systematic Review Findings Into Clinical Action https://pubmed.ncbi.nlm.nih.gov/35667063 In a model of infection by the virus of COVID-19, CBD enhanced the cellular anti-viral response & increased the infected cell’s rate of apoptosis (cellular suicide) Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein https://pubmed.ncbi.nlm.nih.gov/35568225 A big review of how the endocannabinoid system works with the renin-angiotensin systems (a hormonal system that regulates blood pressure, your balance of fluids & electrolytes, as well as the resistance strength of your circulatory system) & how this might be helpful for treating COVID-19 Cross-Talk between the (Endo)Cannabinoid and Renin-Angiotensin Systems: Basic Evidence and Potential Therapeutic Significance https://pubmed.ncbi.nlm.nih.gov/35683028 In skin stem cells, UVB radiation causes cell death while the presence of anandamide & CBD protected them from cell death, partially via the COX2 pathway Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids https://www.mdpi.com/2218-273X/12/6/842

In mice with kidney injuries, inactivating the FAAH enzyme (something CBD does) protects against scarring via the AEA-COX-2 pathway Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis https://pubmed.ncbi.nlm.nih.gov/35710061 In prostate cancer cells, when combining with the common treatment cisplatin, CBD worked better than a full cannabis extract The antitumor activity of cannabis sativa and CBD in prostate cancer PC3 cells https://aacrjournals.org/cancerres/article/82/12_Supplement/3714/701192

A comprehensive report on delta-8 THC by Dr. Linda Klumpers https://learn.uvm.edu/blog/blog-health/cannabis-faculty-member-publishes-comprehensive-report-on-delta-8-thc