Best of cannabinoid science this week...
In humans with COVID-19, PEA reduced inflammatory markers & may reduce the severity of the disease
Effects of Palmitoylethanolamide on Proinflammatory Markers in Adults Recently Diagnosed With COVID-19
https://academic.oup.com/cdn/article/6/Supplement_1/200/6606939
In humans with pelvic pain, a combination of PEA & magnesium reduced pain & increased quality of life
A Palmitoylethanolamide (PEA) and Magnesium Based Product (PEAMag) Reduces the Pain and Improves Quality of Life in Patients Affected by Acute and Chronic Pelvic Pain
http://www.clinicalcasereportsint.com/open-access/a-palmitoylethanolamide-pea-and-magnesium-based-product-peamag-reduces-the-8862.pdf
A case report of using CBD for a severe epilepsy that caused this 3-year-old to be seizure free for 16 months
Cannabidiol Successful Therapy for Developmental and Epileptic Encephalopathy Related to CYFIP2
https://openneurologyjournal.com/VOLUME/16/ELOCATOR/e1874205X2203290/ABSTRACT
A review of the evidence suggests the promising benefits of cannabis for migraine
Medical Cannabis for the Treatment of Migraine in Adults: A Review of the Evidence
https://pubmed.ncbi.nlm.nih.gov/35711271
A review of the use of CBD for sick skin
Topical cannabidiol (CBD) in skin pathology - A comprehensive review and prospects for new therapeutic opportunities
https://pubmed.ncbi.nlm.nih.gov/35695447
An editorial on using cannabis & cannabinoids for treating the pain of endometriosis
Is it the Ideal Time to Start Prescribing Cannabis Derivatives to Treat Endometriosis-associated Pain?
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0042-1749430
A systematic review on translating the chronic pain research into clinical cannabinoid action
Cannabinoids for Chronic Pain: Translating Systematic Review Findings Into Clinical Action
https://pubmed.ncbi.nlm.nih.gov/35667063
In a model of infection by the virus of COVID-19, CBD enhanced the cellular anti-viral response & increased the infected cell’s rate of apoptosis (cellular suicide)
Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein
https://pubmed.ncbi.nlm.nih.gov/35568225
A big review of how the endocannabinoid system works with the renin-angiotensin systems (a hormonal system that regulates blood pressure, your balance of fluids & electrolytes, as well as the resistance strength of your circulatory system) & how this might be helpful for treating COVID-19
Cross-Talk between the (Endo)Cannabinoid and Renin-Angiotensin Systems: Basic Evidence and Potential Therapeutic Significance
https://pubmed.ncbi.nlm.nih.gov/35683028
In skin stem cells, UVB radiation causes cell death while the presence of anandamide & CBD protected them from cell death, partially via the COX2 pathway
Influence of Inhibition of COX-2-Dependent Lipid Metabolism on Regulation of UVB-Induced Keratinocytes Apoptosis by Cannabinoids
https://www.mdpi.com/2218-273X/12/6/842
In mice with kidney injuries, inactivating the FAAH enzyme (something CBD does) protects against scarring via the AEA-COX-2 pathway
Inactivation of fatty acid amide hydrolase protects against ischemic reperfusion injury-induced renal fibrogenesis
https://pubmed.ncbi.nlm.nih.gov/35710061
In prostate cancer cells, when combining with the common treatment cisplatin, CBD worked better than a full cannabis extract
The antitumor activity of cannabis sativa and CBD in prostate cancer PC3 cells
https://aacrjournals.org/cancerres/article/82/12_Supplement/3714/701192
A comprehensive report on delta-8 THC by Dr. Linda Klumpers https://learn.uvm.edu/blog/blog-health/cannabis-faculty-member-publishes-comprehensive-report-on-delta-8-thc
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