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Research Roundup: June 20, 2023

Best of cannabinoid science this week...

An analysis of the barriers of access to CBD for children with neuro disabilities Barriers for access to cannabidiol as a treatment option for children with neuro-diverse disabilities: A qualitative key informants method

On the efficacy of using CBD for treatment-resistant epilepsy Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies in the Expanded Access Program

Top cannabinoid researchers on the lessons they've learned from the last 30 years of targeting the endocannabinoid system

Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years

In a dog with compulsive disorder, using cannabis & melatonin lowered their compulsive episodes Combining cannabis and melatonin treatment with a rehabilitation program improved symptoms in a dog with compulsive disorder: A case report

In a survey of equine industry professionals, the majority believed CBD should be legal in competition, that it provided benefits for the horses such as calming & many believed it to reduce inflammation as effectively as NSAIDs Industry perceptions of cannabidiol use in horses

A review of drugs to treat psychosis find help from CBD Use of psychoactive substances as a treatment for psychosis

In neurons, CBD protected them from the dopamine toxicity of paraquat via antioxidant & antiapoptotic (cellular suicide) effects, suggesting them as a treatment for Parkinson's disease Cannabidiol Protects Dopaminergic-like Neurons against Paraquat- and Maneb-Induced Cell Death through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson's Disease

In a mouse model of colitis, dietary CBD suppressed inflammation & enhanced gut barrier function via the PKA & AMPK signaling pathways Dietary cannabidiol activates PKA/ERK/AMPK signaling and attenuates chronic inflammation and leaky gut in DSS-induced colitis mice

In a model of inflammatory bowel disease, white blood cell migration was inhibited by anandamide, CBD & AM-1241 (an activator of the CB2 receptor) Development of a new cannabinoid-based therapy to treat inflammatory bowel disease

In mice, 8 weeks of CBG lowered their blood pressure Chronic cannabigerol administration lowers blood pressure in phenotypically normal mice

In a mouse model of Alzheimer's, the cannabis terpenes linalool & cineol combined well with aerobic exercise to cause a protective effect via the genetic expression of Bdnf, Ngf & Creb The Effect of Linalool, Cineole, Beta bourbonin and Aerobic Exercises as Protective Approaches in Mice with Alzheimer's Disease


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