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Research Roundup: June 14, 2021



Best of the Week...


In various cell types, CBD acted as an antioxidant in healthy cells & as a killer in cancer cells New Insights on Hemp Oil Enriched in Cannabidiol: Decarboxylation, Antioxidant Properties and In Vitro Anticancer Effect https://pubmed.ncbi.nlm.nih.gov/34067035/ 2017: A review from an endocannabinoid hero, Dr. Cecilia Hillard, on all of the studies that have been done relating the levels of endocannabinoids in your blood to your health status Circulating Endocannabinoids: From Whence Do They Come and Where are They Going? https://pubmed.ncbi.nlm.nih.gov/28653665/

Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

A review of CBD for substance use disorder Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders https://pubmed.ncbi.nlm.nih.gov/34093179/ A new review of drug interactions from THC & CBD Delta-9-Tetrahydrocannabinol and Cannabidiol Drug-Drug Interactions https://www.karger.com/Article/FullText/507998 their chart: https://sites.psu.edu/cannabinoid/files/2020/06/NTI-Meds-to-be-Closely-Monitored-when-Co-Administered-with-Cannabinoids_2020_04_25.pdf In humans, one dose of 800 mg of CBD did not alter their pain levels Pain response to cannabidiol in induced acute nociceptive pain, allodynia, and hyperalgesia by using a model mimicking acute pain in healthy adults in a randomized trial (CANAB I) https://pubmed.ncbi.nlm.nih.gov/34086631/ A review of how the cannabinoids similarly affect inflammation of the guts, lungs & skin Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier https://pubmed.ncbi.nlm.nih.gov/34072930/ New research has confirmed a remarkable similarity between the surface of our skin, the lining of our guts & the surface of our lungs. This makes sense because it’s the main places where our bodies are exposed to the outside world. It’s especially true in how these surfaces respond to inflammation. And so this review looks at the work done on the endocannabinoid system & the cannabinoids on inflammation in these areas. A review of cannabinoids for the regulation of anxiety Endocannabinoids, Cannabinoids and the Regulation of Anxiety https://pubmed.ncbi.nlm.nih.gov/34116110/ A review of how the cannabinoids alter the immune system via microRNAs (short strands of RNA that regulate proteins after they’ve been created from the DNA blueprint) Cannabinoid-induced changes in the immune system: The role of microRNAs https://pubmed.ncbi.nlm.nih.gov/34107381/ A review looks at the CB2 receptor & β-caryophyllene (the terpene that binds to it) A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid https://pubmed.ncbi.nlm.nih.gov/34091179/ β-caryophyllene tends to be the most abundant terpene in the plant – as well as in our products. It’s also the main terpene that, because of its ability to activate the CB2 receptor, can be considered a dietary cannabinoid. On why the CB2 receptor is protective of the brain in neurodegenerative disorders Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB 2 R modulators in neurodegenerative diseases https://pubmed.ncbi.nlm.nih.gov/34089867/ This review suggests the cannabinoids as uniquely suited to treating the dysfunctions of Alzheimer’s disease The therapeutic benefits of natural cannabinoids in delaying the pathophysiology of Alzheimer's disease https://rsdjournal.org/index.php/rsd/article/view/15418

Preclinical Research & Cannabinoid Chemistry

In mice, they find that the CB1 receptors in the brain’s ventromedial hypothalamus regulates glucose homeostasis CB1Rs in VMH Neurons Regulate Glucose Homeostasis but not Body Weight https://pubmed.ncbi.nlm.nih.gov/34097543/ On human placentas, anandamide acts as a modulator of signals during labor & birth Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor https://www.frontiersin.org/articles/10.3389/fphys.2021.667367/full As someone who’s about to become a papa for the second time, this intrigues me.