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Research Roundup: June 11, 2024



Best of cannabinoid science this week...


In a large trial of people with anxiety, 15 weeks of CBD significantly improved anxiety scores as well as depression & sleep quality

Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial

 

In people with a range of inflammatory skin diseases, two months of topical cannabis caused pain relief [Spanish]

[Topical Use of Cannabis in Inflammatory Diseases in patients of the IPS Salud Social in Barranquilla, Colombia]


On the medical cannabis preferences of older adults

Medical Cannabis for Patients Over Age 50: A Multi-site, Prospective Study of Patterns of Use and Health Outcomes


In insomnia patients using oral cannabis products at night, there was a “notable” lack of next day impairment on 28 different tests of cognitive & psychomotor function

Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial

 

Young adults who use cannabis seemed to exercise slightly more than those who did not

Recent Cannabis Use and Accelerometer-Measured Physical Activity and Sedentary Behavior Among Young-to-Midlife Adults: An Analysis of the National Health and Nutrition Examination Survey from 2011 to 2014


 

In healthy volunteers, 20 milligrams of CBG caused reductions in anxiety & enhancements to verbal memory

Acute Effects of Cannabigerol on Anxiety, Stress, and Mood: A Double-Blind, Placebo- Controlled, Crossover, Field Trial


In a survey of UK vets & pet owners, the largest use of CBD was for musculoskeletal disorders

Veterinary professional (VP) and owner perceptions of Cannabinoid use in United Kingdom (UK) companion animals


On the antidepressant effects of CBD, a review of the involvement of the serotonin & BDNF-TrkB signaling pathway

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect

 

A review of PEA for gut disorders

Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders


For autism, a review of targeting the endocannabinoid system

Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder

 

For the pain of Parkinson's disease, a review of the interactions between the endocannabinoids & dopamine in the basal ganglia

Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson's disease


In a mouse model of polycystic ovary syndrome, low doses of THC improved their inflammatory response & shifted the balance of macrophages (white blood cell type) away from inflammation

Revitalizing polycystic ovary syndrome: The therapeutic impact of low-dose ∆9 tetrahydrocannabinol through reduction of oxidative stress and modulation of macrophage polarization

 

In a male mouse model of PTSD, CBD lowered symptoms & neuroinflammation via CB2 receptors in the brain

Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice

 

In a model of neuroinflammation, CBD lowered the inflammation via CB2 receptors, the NLRP3 inflammasome complex, the PPARγ receptors (that modulate genetic transcription) & the microglia (guardian immune cells of the brain)

Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ


Cannabis extracts killed bad bacteria & helped good gut bacteria as well as changing immunomodulatory levels

Antimicrobial, Probiotic, and Immunomodulatory Potential of Cannabis sativa Extract and Delivery Systems

https://pubmed.ncbi.nlm.nih.gov/38667045 And on the efficacy of cannabis extracts against antibiotic-resistant bacteria

In vitro Antibacterial Activity of Ethanolic Tanao Si Kan Dang RD1 (Cannabis sativa L.) Extracts Against Human Antibiotic-Resistant Bacteriahttps://pubmed.ncbi.nlm.nih.gov/38686733/ And CBD significantly reduce the growth of the fungus Candida albicans

Effect of cannabidiol (CBD) on Candida albicans pathogenesis





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