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Research Roundup: June 1, 2021




Best of the Week...

This review of the cannabinoids & the immune system says that CBD is one of the main modulators of the immune system Therapeutic Prospects of Cannabinoids in the Immunomodulation of Prevalent Autoimmune Diseases https://pubmed.ncbi.nlm.nih.gov/34030476/ “CBD was found to be one of the main modulators of the immune response. This molecule decreased the number of Th1 and Th17 proinflammatory cells and the production of the proinflammatory cytokines, interleukin (IL)-1, IL-12, IL-17, interferon (IFN)-γ, and tumor necrosis factor alpha, in mouse models of MS and DMT1.” In mouse exposed to UV radiation, CBD applied to skin helped to protect their blood from the negative consequences via several mechanisms Oxidative Stress and Its Consequences in the Blood of Rats Irradiated with UV: Protective Effect of Cannabidiol https://www.mdpi.com/2076-3921/10/6/821 This review looks at how the ECS interacts with your fat tissue & how it regulates your metabolism Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism https://www.mdpi.com/2073-4409/10/6/1279/htm A review on targeting the ECS for the neuropathic pain of diabetes The endocannabinoid system as a therapeutic target in diabetic peripheral neuropathic pain: A review https://www.jmau.org/preprintarticle.asp?id=316861;type=0

Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

In humans, CBD & PEA found safe for the skin Tolerability Profile of Topical Cannabidiol and Palmitoylethanolamide: A Compilation of Single-Center Randomized Evaluator-Blinded Clinical and In Vitro Studies in Normal Skin https://pubmed.ncbi.nlm.nih.gov/34022073/ In two epilepsy centers, half of the participants found help for their Dravet syndrome with CBD Two-center experience of cannabidiol use in adults with Dravet syndrome https://pubmed.ncbi.nlm.nih.gov/34052628/ This review looks at CBD & the mitochondria (the powerhouse of the cell) Regulatory Effects of Cannabidiol on Mitochondrial Functions: A Review https://www.mdpi.com/2073-4409/10/5/1251 This review looks at the effect of CBD on your cell’s sodium channels – major regulators of the electrical signaling of cells Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications https://pubmed.ncbi.nlm.nih.gov/34027742/

This review looks at the “widespread therapeutic potential” of CBD to enhance chemotherapy treatments for cancer Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer? https://www.mdpi.com/2218-273X/11/5/766

This review looks at the emerging evidence that the ECS is vital for the development of your auditory function Cannabinoid Signaling in Auditory Function and Development https://www.proquest.com/openview/f0c8b0109a2481a79d52727eebd7ff3c/1?pq-origsite=gscholar&cbl=2046457 This review looks at the ECS & cancer as well as how targeting the CB1 & CB2 receptors may be a potential therapy The Interplay between the Immune and the Endocannabinoid Systems in Cancer https://www.mdpi.com/2073-4409/10/6/1282

Preclinical Research & Cannabinoid Chemistry

In horses, a single dose of 250 mg of CBD caused no adverse events & showed minimal effects on behavior Safety and behavioural effects of cannabidiol applied as an oral administration in horses https://www.sciencedirect.com/science/article/pii/S0737080621002288 In cells from aging horses, CBD reduced their inflammatory cytokines Effects of cannabidiol on the in vitro lymphocyte pro-inflammatory cytokine production of senior horses https://www.sciencedirect.com/science/article/pii/S0737080621002987 In horses, a single serving of CBD in olive oil did not alter their heart rates or feed intakes Evaluation of oral supplementation of cannabidiol (CBD) in horses https://www.sciencedirect.com/science/article/pii/S0737080621001556 In horses, full-spectrum CBD helped them to not startle as much when someone scared them with an umbrella as they were coming around a corner Cannabidiol in the horse: Effects on movement and reactivity https://www.sciencedirect.com/science/article/pii/S073708062100174X In a mouse model of stroke, CBG & CBDV protective of the blood-brain barrier

Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood-Brain Barrier Under Ischemic Conditions

https://pubmed.ncbi.nlm.nih.gov/33998890/ In zebrafish, the obesity inducing effects of the plastic additives bisphenol A (BPA) & tetrabromobisphenol A (TBBPA) were partially caused by activation of the CB1 receptor New insights into bisphenols induced obesity in zebrafish (Danio rerio): activation of cannabinoid receptor CB1 https://www.sciencedirect.com/science/article/abs/pii/S0304389421010645