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Research Roundup: July 9, 2024

Best of cannabinoid science this week...

In people with multiple sclerosis, Sativex (1:1 CBD:THC sprays) improved gait & reduced spasticity, pain & bladder dysfunction

Effectiveness, Safety and Patients' Satisfaction of Nabiximols (Sativex®) on Multiple Sclerosis Spasticity and Related Symptoms in a Swiss Multicenter Study


For pain, using data from “Project Twenty21” on medicinal cannabis in the UK, “prescribed cannabis was associated with marked reductions in pain severity and interference and with improvements in aspects of general health and quality of life”

Prescribed Medicinal Cannabis for the Treatment of Chronic Pain Comorbid with Depression: Real World Evidence from Project Twenty21


In people with gynecological cancers, they reported using cannabis for enhanced mood & physical activity, improvements in sleep, stimulation of appetite & mitigation of symptoms associated with cancer treatment

Factors Affecting the Decision on Cannabis Use in Gynecologic Cancer Patients After the Legalization of Cannabis

In people with post-infection olfactory disorders, the usual treatment of olfactory training may be supplemented with PEA & luteolin (a flavonoid commonly paired with PEA)

Palmitoylethanolamide and Luteolin for postinfectious olfactory disorders: How clinically meaningful is its effect?

For vasospastic & vaso-occlusive disorders (disorders of blood flow), a review of 32 studies on using cannabinoids

Vasoactive and Antifibrotic Properties of Cannabinoids and Applications to Vasospastic/Vaso-Occlusive Disorders: A Systematic Review

For Alzheimer’s disease, a review of the research on the interplay between the cannabinoid system & orexin system (a regulator of arousal, wakefulness, energy homeostasis, appetite, cognition & mood)

Cannabinoid and Orexigenic Systems Interplay as a New Focus of Research in Alzheimer's Disease

For neurological disorders, a review of CBD's many targets with a focus on Apo-lipoprotein

Unveiling the Relationship between Cannabidiol, Apo-lipoprotein and Neurological Disorders: A Comprehensive Review of Molecular Targets and Current Findings

A review of the data on using cannabinoids to treat autism, ADHD & Alzheimer's disease

Endocannabinoid System Changes throughout Life: Implications and Therapeutic Potential for Autism, ADHD, and Alzheimer's Disease

For Lennox-Gastaut syndrome (a rare childhood epilepsy), a review of the efficacy of the cannabinoids & their effects on the endocannabinoid system

Lennox-Gastaut Syndrome, the Endocannabinoid System, and Therapeutic Applications of Known Cannabinoids

In a mouse model of colitis, PEA reduced clinical signs of colitis, lowered injury to the mucosal surfaces & suppressed white blood cell recruitment, suggesting its utility for controlling symptoms during the acute phase of intestinal inflammation

Amelioration of Dextran Sodium Sulfate-Induced Colitis in Mice through Oral Administration of Palmitoylethanolamide


In a rat model of arthritis, CBG improved clinical scores & reduced the genetic expression of pro-inflammatory cytokines



In a neuronal model of aging, the impaired delivery of cholesterol from the astrocytes (brain support cells) can be rescued by endocannabinoids or CBD

Lysosomal cholesterol accumulation in aged astrocytes impairs cholesterol delivery to neurons and can be rescued by cannabinoids


For pain, intriguing receptor analysis found that CBD caused profound inhibition of nociceptors (pain receptors) in the pain signaling pathway

Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons


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