Research Roundup: July 29, 2025
- Lex Pelger
- Jul 20
- 3 min read
Best of cannabinoid science this week...
In people with chronic pain, medical cannabis users exhibited significantly lower healthcare utilization with fewer urgent care visits, emergency department visits & unhealthy days per month
Medical Cannabis Use and Healthcare Utilization Among Patients with Chronic Pain: A Causal Inference Analysis Using TMLE
And in people with chronic pain, incorporating the chemical composition of their cannabis improved the prediction of pain relief effects, with particular efficacy from the terpenoids α-bisabolol & eucalyptol
Machine-learning of medical cannabis chemical profiles reveals analgesia beyond placebo expectations
In young people with various types of seizure disorders, CBD lowered their seizure levels
Retrospective Multicenter Chart Review Study of Adjunctive Cannabidiol for Seizures Associated with Lennox–Gastaut Syndrome, Dravet Syndrome and Tuberous Sclerosis Complex
And in children with drug-resistant epilepsy, a multi-center analysis of CBD found reductions in seizure frequency, with 10% becoming seizure-free
A multicenter study on the use of purified cannabidiol for children with treatment-resistant developmental and epileptic encephalopathies
In a 2-year-old with cystic fibrosis, a case report of CBD & low doses of THC for significant improvements in breathing, sleep, anxiety & agitation, social interactions, concentration, & emotional stability
Cannabidiol reduces symptoms and improves quality of life in cystic fibrosis: a case report
In pregnant & parenting people, interviews found that they used cannabis to manage pregnancy symptoms, to maintain parental focus & relieve stress & to manage mental health symptoms
‘It Helped to Calm Me’: Perspectives on Cannabis Use During Pregnancy and Parenting from Certified Patients in Pennsylvania
In dogs & cats, a review of 22 articles on the efficacy of CBD for osteoarthritis, epilepsy, atopic dermatitis, post-surgical pain & behavioral issues as well as cannabis for pain, behavior & seizures
Cannabis-based products for medicinal use in dogs and cats: a systematic review
A review of cannabis & veterinary medicine
Cannabis and Veterinary Medicine
In dogs with lymphoma undergoing chemotherapy, a CBD/CBDA-rich hemp oil did not interfere with the efficacy of their treatment & was well tolerated
Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy
In dogs taking full-spectrum CBD/CBDA extracts or isolates, CBDA had higher absorption than CBD, with no evidence for enhanced absorption from full-spectrum products
Limited 12-hour pharmacokinetic assessment of CBD and CBDA isolates compared to their full-spectrum extracts in healthy adult beagles
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1639846/abstract
In dogs, treats with CBD, L-tryptophan & α-casozepine treats produced mild stress-reducing effects
Treats containing cannabidiol (CBD), L-Tryptophan and α-casozepine have a mild stress-reducing effect in dogs
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1632868/abstract
For oleoylethanolamide (the endocannabinoidome of satiety), this review of 13 human studies found substantial reductions in fasting blood sugar, waist circumference, triglycerides & inflammation factors as well as increased total antioxidant capacity
The effect of oleoylethanolamide supplementation on cardiometabolic factors: a systematic review and meta-analysis
For diabetes, a review of the therapeutic potential of cannabis
Therapeutic Potential of Cannabis Plant in Diabetes
For cannabis & dentistry, a review of 25 studies found most highlighted anti-inflammatory benefits, particularly for CBD, but some showed negative periodontal effects from smoking
CANNABIS IN DENTISTRY: THERAPEUTIC AND ADVERSE EFFECTS ON ORAL TISSUES - SYSTEMATIC REVIEW
In childhood epilepsy, a review of the dysregulation of the endocannabinoid system (great charts!)
Dysregulation of the Cannabinoid System in Childhood Epilepsy: From Mechanisms to Therapy
In the nonopioid analgesics, a review of their synergistic effects with the endocannabinoid system
The Role of the Endocannabinoid System in the Mechanism of Action of Nonopioid Analgesics
In older female mice with open wounds, a chronic low dose of oral THC improved the wound closure rate & lowered inflammation via the immune cells
A chronic low dose of Δ9-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice
In a mouse model of HIV-related pain, CBD, CBN, & CBGA lessened visceral pain with gendered differences
Sex differences in the capacity of minor phytocannabinoids to attenuate nociceptive insults in HIV-1 Tat-expressing mice
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