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Research Roundup: July 11, 2023



Best of cannabinoid science this week...


In people with untreated high blood pressure, 24 hours of CBD significantly lowered their systolic pressure, arterial pressure & arterial stiffness The Influence of Oral Cannabidiol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Untreated Hypertension: A Double-Blind, Placebo-Controlled, Cross-Over Pilot Study https://pubmed.ncbi.nlm.nih.gov/37291376/

and the ability of CBD to lower blood pressure seems linked to serum levels of urotensin (the strongest known vasoconstrictor (besides my ex-wife)) Effects of CBD supplementation on ambulatory blood pressure and serum urotensin-II concentrations in Caucasian patients with essential hypertension: A sub-analysis of the HYPER-H21-4 trial https://pubmed.ncbi.nlm.nih.gov/37321059/


In epilepsy patients, the quality-of-life improvement from Epidiolex (pharmaceutical CBD) Quality improvement study in epilepsy patients treated with Epidiolex® https://pubmed.ncbi.nlm.nih.gov/37390612/


A review on the therapeutic uses of purified CBD

The therapeutic potential of purified cannabidiol


A review of using CBD to treat schizophrenia,

Cannabidiol as a Treatment for Schizophrenia

anxiety,

Current Evidence of Cannabidiol's Potential as an Anxiolytic Agent

autism,

Therapeutic Profile of Cannabidiol in the Broad Symptomatology of Autism Spectrum Disorder: Evidence From Basic Science to Clinical Approaches

and neuropathic facial pain The role of cannabidiol in modulating chronic neuropathic orofacial pain https://www.magonlinelibrary.com/doi/abs/10.12968/denu.2023.50.6.512


In a review of the rare complex epilepsy known as Doose syndrome, they highlight CBD as a promising new treatment A MINI REVIEW OF DOOSE SYNDROME: CLINICAL MANIFESTATIONS, DIAGNOSIS, AND TREATMENT https://revues.imist.ma/index.php/MJPH/article/view/39024


An editorial on using CBD in psychiatric practice Cannabidiol (CBD) in psychiatric clinical practice: Current data https://pubmed.ncbi.nlm.nih.gov/37246102/


In stressed rats, a broad-spectrum hemp extract (no THC) lowered the biomarkers for oxidative stress Effect of Broad-Spectrum Hemp Extract on Neurobehavioral Activity on the Immobilization Stress-Induced Model in Sprague Dawley Rats https://pubmed.ncbi.nlm.nih.gov/37332853/


In a mouse model of migraines, CBD helped with the pain though it only helped the males with the related anxiety & pain behaviors Preclinical effects of cannabidiol in an experimental model of migraine https://pubmed.ncbi.nlm.nih.gov/37310430/


In a mouse model of a urinary tract infection, β-caryophyllene (one of the most common terpenes in cannabis) reduced bacteria in the urine & bladder tissues as well as reducing bladder inflammation & improving pain behaviors Antibacterial and Analgesic Properties of Beta-Caryophyllene in a Murine Urinary Tract Infection Model https://pubmed.ncbi.nlm.nih.gov/37241885/

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