Best of cannabinoid science this week...
Favorite CBD pharmacology chart of the week:
While treating people for cannabis use disorder with large levels of CBD, these researchers found no problems with memory impairment or broader cognitive effects & at 800 milligrams per day it may have even improved working memory manipulation
Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder
https://pubmed.ncbi.nlm.nih.gov/36598543/
In a mouse model of sepsis (an extreme immune reaction to an infection), CBD suppressed the inflammatory cytokine storm & protected the heart & kidneys from injury
Cannabidiol Suppresses Cytokine Storm and Protects Against Cardiac and Renal Injury Associated with Sepsis
https://pubmed.ncbi.nlm.nih.gov/36594988/
In dental stem cells, CBD lowered inflammation as well as increased bone regeneration
Cannabidiol Rescues TNF-α-Inhibited Proliferation, Migration, and Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells
https://pubmed.ncbi.nlm.nih.gov/36671503/
In a mouse model of pain, how CBG lowers pain via the CB2 & TRPV1 receptors
The antinociceptive activity and mechanism of action of cannabigerol
https://www.sciencedirect.com/science/article/pii/S0753332222015529
In motor neuron cells, CBG increased the genetic expression for remodeling the skeleton of this cell & guiding their axons
Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
https://pubmed.ncbi.nlm.nih.gov/36616322/
In a cellular model of rheumatoid arthritis, CBG lowered inflammation via the TRPA1 receptors
Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1
https://pubmed.ncbi.nlm.nih.gov/36614296
In those following the Mediterranean diet for three years, they saw significant improvements in their weight, glycemic index & heart health that were correlated to changes in their endocannabinoid levels, though with the usual gender differences
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome
https://pubmed.ncbi.nlm.nih.gov/36532543/
In a model of multiple sclerosis, omega-three fatty acids act as building blocks for the endocannabinoids that reduced the disease severity, suggesting adding dietary solutions to your treatment
Role of Omega-3 Endocannabinoids in the Modulation of T-cell Activity in a Multiple Sclerosis Experimental Autoimmune Encephalomyelitis (EAE) Model
https://pubmed.ncbi.nlm.nih.gov/36626985/
A review on using nano CBD for central nervous system disorders
Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
https://pubmed.ncbi.nlm.nih.gov/36678832/
Further evidence that it's unlikely for CBD to convert to THC in the stomach
The scientific controversy on the conversion of CBD into THC in the human stomach: Molecular modelling and experimental results compared
https://www.sciencedirect.com/science/article/pii/S2468170923000036