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Research Roundup: Jan 31, 2023

Best of cannabinoid science this week...

Favorite CBD pharmacology chart of the week:

While treating people for cannabis use disorder with large levels of CBD, these researchers found no problems with memory impairment or broader cognitive effects & at 800 milligrams per day it may have even improved working memory manipulation

Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder

In a mouse model of sepsis (an extreme immune reaction to an infection), CBD suppressed the inflammatory cytokine storm & protected the heart & kidneys from injury

Cannabidiol Suppresses Cytokine Storm and Protects Against Cardiac and Renal Injury Associated with Sepsis

In dental stem cells, CBD lowered inflammation as well as increased bone regeneration

Cannabidiol Rescues TNF-α-Inhibited Proliferation, Migration, and Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells

In a mouse model of pain, how CBG lowers pain via the CB2 & TRPV1 receptors

The antinociceptive activity and mechanism of action of cannabigerol

In motor neuron cells, CBG increased the genetic expression for remodeling the skeleton of this cell & guiding their axons

Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study

In a cellular model of rheumatoid arthritis, CBG lowered inflammation via the TRPA1 receptors

Anti-Inflammatory Effects of Cannabigerol in Rheumatoid Arthritis Synovial Fibroblasts and Peripheral Blood Mononuclear Cell Cultures Are Partly Mediated by TRPA1

In those following the Mediterranean diet for three years, they saw significant improvements in their weight, glycemic index & heart health that were correlated to changes in their endocannabinoid levels, though with the usual gender differences

Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome

In a model of multiple sclerosis, omega-three fatty acids act as building blocks for the endocannabinoids that reduced the disease severity, suggesting adding dietary solutions to your treatment

Role of Omega-3 Endocannabinoids in the Modulation of T-cell Activity in a Multiple Sclerosis Experimental Autoimmune Encephalomyelitis (EAE) Model

A review on using nano CBD for central nervous system disorders

Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

Further evidence that it's unlikely for CBD to convert to THC in the stomach

The scientific controversy on the conversion of CBD into THC in the human stomach: Molecular modelling and experimental results compared


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