Best of cannabinoid science this week...
In a case study where isolated CBD stopped being effective for autism once the patient hit puberty, the power of enriching with terpenes
Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report
On terpenes, a suggestion that some patients prefer smoking because more terpenes are preserved & perhaps we should be adding terpenes to our liquid extracts
Optimal Treatment with Cannabis Extracts Formulations Is Gained via Knowledge of Their Terpene Content and via Enrichment with Specifically Selected Monoterpenes and Monoterpenoids
A case study of using THC & CBD on a patient with complex pain
Integration of Cannabis Extract Tetrahydrocannabinol:Cannabidiol in an Interdisciplinary Therapy Setting: A Case of Chronic Multilocular Pain Disorder
In Danish patients with hard-to-treat chronic pain, oral cannabinoids were safe & helped with some of their pain - THC & CBD worked better together
Safety and effectiveness of cannabinoids to Danish patients with treatment refractory chronic pain-A retrospective observational real-world study
Among patients taking CBD for a month, it significantly improved well-being, anxiety, sleep disturbance & pain
The Safety and Effectiveness of Commercially Available Cannabidiol Products for Health and Well-Being: A Randomized, Multi-Arm, Open-Label Waitlist-Controlled Trial
A long study in Australia followed ~4k medical patients & found THC & CBD treatments helped on all outcomes over the course of two years
A large Australian longitudinal cohort registry demonstrates sustained safety and efficacy of oral medicinal cannabis for at least two years
In kids with Fragile X Syndrome (a genetic developmental disorder that causes intellectual disability), a pharmaceutical CBD gel helped with isolation, irritability, disruptive behaviors & social interactions in the subset with the relevant gene most silenced (most severe cases)
A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)
Using cannabinoids for nociplastic pain such as in fibromyalgia
Consider cannabinoids as an individual therapeutic trial in nociplastic pain
In stress-related psychiatric disorders such as anxiety, schizophrenia & depression, a review of how CBD’s ability to methylate (turn off) genes in the DNA can help regulate enzymes that help with these disorders
Regulation of DNA Methylation by Cannabidiol and Its Implications for Psychiatry: New Insights from In Vivo and In Silico Models
A review of using CBD for stress-related disorders
Potential Utility of Cannabidiol in Stress-Related Disorders
In a strong review of 33 studies on PEA for cognitive decline, PEA improved neurobehavioral functions like memory & learning, reduced oxidative stress & inflammation, rebalanced glutamate (the brain’s primary excitatory neurotransmitter), increased neuron survival & promoted neurogenesis (the creation of new brain cells) + so much more
Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence
On using PEA for chronic pelvic pain syndrome
Chronic Pelvic Pain Syndrome, General Conservative and Medical Management and Palmitoylethanolamide (PEA) Efficacy
A big review on how CBD may help with muscle recovery via its effects on skeletal muscle metabolism, inflammation & tissue regeneration
Molecular Mechanisms Through Which Cannabidiol May Affect Skeletal Muscle Metabolism, Inflammation, Tissue Regeneration, and Anabolism: A Narrative Review
A review of CBD for modulating the immune system
Cannabinoids as Immune System Modulators: Cannabidiol Potential Therapeutic Approaches and Limitations
A review of the potential of CBD for dentistry
Cannabidiol, the Journey of Cannabis from a Social Stigma to a Miracle Drug in Dentistry
and an even bigger review of CBD for dentistry
Cannabidiol in Dentistry: A Scoping Review
A meta-analysis of 6 studies on CBD helping with rare childhood epilepsies
Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
In a mouse model of epilepsy, a study of why CBD makes the standard treatment of clobazam work better
Pharmacodynamic synergism contributes to the antiseizure action of cannabidiol and clobazam
A review of everyone’s favorite minor cannabinoid: CBN
Cannabinol: History, Syntheses, and Biological Profile of the Greatest "Minor" Cannabinoid
A review of the dosing of THC, CBD & THCV for various conditions
A Systematic Review of Medical Cannabinoids Dosing in Human
and a big review of the negatives of CBD drawn from 12 studies found mostly the usual mild adverse events
Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020–2022)
A review of targeting the CB2 receptor for proteinopathies (prevalent neurodegenerative disorders such as Alzheimer’s and Parkinson’s)
Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
In a mouse model of diabetes, CBD lowered blood sugar
Analysis of hypoglycaemic effects of cannabidiol following oral and intraperitoneal administration in healthy rats
In a mouse model of sickle cell disease, CBD lessened the chronic & acute pain by decreasing inflammation & oxidative stress Cannabidiol Attenuates Chronic and Acute Hyperalgesia in Sickle Mice By Reducing Inflammation and Oxidative Stress https://ashpublications.org/blood/article/140/Supplement%201/8226/488015
In a mouse model of hemophilia, PEA helped with pain & the symptoms of arthritis such as joint inflammation Palmitoylethanolamide Attenuates Pain-like Behavior in Factor VIII Deficient Mice https://ashpublications.org/blood/article/140/Supplement%201/5578/492940
In mice, a single dose of CBD reduced obsessive-compulsive symptoms & object memory in males but not females while it lessened anxiety behavior in both, probably via the potassium channels
Single cannabidiol administration affects anxiety-, obsessive compulsive-, object memory-, and attention-like behaviors in mice in a sex and concentration dependent manner
In a rat model of schizophrenia being treated by risperidone (an increaser of dopamine that leads to movement disorders), oral CBD lowered their blood sugar, lessened their repetitive chewing motions, increased antioxidation & mitigated the metabolic dysregulation & movement problems of risperidone without producing cognitive impairments
Effects of cannabidiol on vacuous chewing movements, plasma glucose and oxidative stress indices in rats administered high dose risperidone
In mice with scarring on their skin & livers, injected CBD lessened scarring & in the model of non-alcohol liver fibrosis, reduced infiltration by immune cells
Cannabidiol markedly alleviates skin and liver fibrosis
In neurons of the striatum (a movement & reward center of the brain frequently damaged in neurodegenerative disorders), CBD protects them via lowering of stress in the endoplasmic reticulum (protein production site of the cell)
Cannabidiol Protects Striatal Neurons by Attenuating Endoplasmic Reticulum Stress