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Research Roundup: Jan 17, 2022



A sweet tribute to Dr. Mechoulam, the father of the endocannabinoid system, by Dr. Maccarrone

Tribute to Professor Raphael Mechoulam, The Founder of Cannabinoid and Endocannabinoid Research

https://www.mdpi.com/1420-3049/27/1/323/htm

A free lecture by the famed Dr. Allyn Howlett (discoverer of the CB1 receptor) on targeting the endocannabinoid system

https://www.nyas.org/ebriefings/2021/targeting-the-endocannabinoid-system-to-treat-human-disease/?tab=understanding%20the%20endocannabinoid%20system



Best of the Week...


And now for the paper that’s been blowing up online, CBGA & CBDA block the entry of the COVID virus into epithelial cells

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

https://pubmed.ncbi.nlm.nih.gov/35007072/

Interview with the researcher

https://www.vice.com/en/article/bvn7gd/the-scientist-who-discovered-cannabis-can-prevent-covid-19

We are pleased to see the new preclinical study about CBDA & CBGA preventing cellular infiltration by SARS-CoV-2 but we do caution that these results occurred in human cells, not humans, and that it is not easy to covert the milligrams of the doses used.

Luckily, both Jimmy Kimmel & Stephen Colbert present their scientific take on these findings

https://www.nytimes.com/2022/01/13/arts/television/jimmy-kimmel-covid-cannabis.html

In cells, CBD helped to augment the anti-viral response that would be raised against SARS-CoV-2

Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein

https://www.biorxiv.org/content/10.1101/2022.01.11.475901v1

This review suggests β-Caryophyllene (the most common terpene in the plant) as a natural treatment for COVID-19

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19

https://pubmed.ncbi.nlm.nih.gov/34054510/

A review of using the cannabinoids for COVID-19

Antimicrobial and Antiviral (SARS-CoV-2) Potential of Cannabinoids and Cannabis sativa: A Comprehensive Review

https://pubmed.ncbi.nlm.nih.gov/34885798/

A study in 28k people found that CBD did not find any association with negative liver function

Observed Impact of Long-term Consumption of Oral Cannabidiol on Liver Function in Healthy Adults

https://www.liebertpub.com/doi/full/10.1089/can.2021.0114

In humans with peripheral neuropathy, a double-blind study showed topical CBD oil caused “significant improvement in pain and other disturbing sensations”

The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities

https://pubmed.ncbi.nlm.nih.gov/31793418/

In rats with a systemic inflammatory response, “CBD treatment significantly improved behavioral tasks and decreased the level of inflammatory cytokines”

Anti-inflammatory potential of cannabidiol (CBD) on combination of caecal slurry, LPS, and E. coli-induced systemic inflammatory response syndrome (SIRS) in Sprague Dawley Rats

https://pubmed.ncbi.nlm.nih.gov/34997430/

This survey shows that most women who used cannabis or cannabinoids (THC, CBD, PEA) for gynecologic conditions found that it improved pain

Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review

https://journals.lww.com/greenjournal/Fulltext/9900/Medical_Cannabis_for_Gynecologic_Pain_Conditions_.362.aspx


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

In humans with gliomas (the most aggressive brain cancer), a nightly dose of THC “improved sleep, functional wellbeing, and quality of life”

A Phase 2 Randomised Clinical Trial Assessing the Tolerability of Two Different Ratios of Medicinal Cannabis in Patients With High Grade Gliomas

https://pubmed.ncbi.nlm.nih.gov/34094937/

2011: In humans with cancer experiencing poor appetite as well as diminished taste & smell, 2.5 mg of THC made their food taste better, increased the calories consumer & increased sleep quality & relaxation

Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial

https://pubmed.ncbi.nlm.nih.gov/21343383/

A review of using cannabis for autoimmune disorders

Cannabis and Autoimmunity: Possible Mechanisms of Action

https://pubmed.ncbi.nlm.nih.gov/34322454/

This review finds THC & CBD helpful for the symptoms of kidney failure

Cannabinoids for Symptom Management in Patients with Kidney Failure

https://pubmed.ncbi.nlm.nih.gov/34987023

This survey finds that consumers use topical cannabis for treating skin conditions like acne & psoriasis

Consumer Perspectives on and Utilization of Medical Cannabis to Treat Dermatologic Conditions

https://pubmed.ncbi.nlm.nih.gov/35005866/

A review of CBD in edibles

Benefits, toxicity and current market of cannabidiol in edibles

https://pubmed.ncbi.nlm.nih.gov/34989307/

A review of CBD for cosmetology & dermatology

Cannabidiol – characteristic and application in cosmetology and dermatology

https://www.researchgate.net/profile/Miroslawa-Grymel/publication/357356916_Cannabidiol_-_characteristic_and_application_in_cosmetology_and_dermatology/links/61d2ffdad45006081689145e/Cannabidiol-characteristic-and-application-in-cosmetology-and-dermatology.pdf

In humans, a look at the pharmacology of taking Spectrum Red softgels (2.5 mg THC, ~.25 mg CBD)

Safety, Pharmacokinetics, and Pharmacodynamics of Spectrum Red Softgels in Healthy Participants

https://pubmed.ncbi.nlm.nih.gov/33848338/

In humans with Tourette syndrome, a MAGL inhibitor (which raises 2-AG levels) caused tic reduction with just a single dose

Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study

https://pubmed.ncbi.nlm.nih.gov/34847610/

It is suggested, but not confirmed, that CBD also reduces MGL degradation of 2-AG.

This review looks at how the cannabinoids regulate the olfactory & visual sensory circuits

Cannabinoids Regulate Sensory Processing in Early Olfactory and Visual Neural Circuits

https://pubmed.ncbi.nlm.nih.gov/34305536/

This review highlights the ability of CBN to protect the mitochondria (powerhouse of the cell) by regulating oxytosis/ferroptosis (oxidative stress pathway)

Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors

https://pubmed.ncbi.nlm.nih.gov/34999187/



Preclinical Research & Cannabinoid Chemistry

In a mouse model of peanut allergies, an activator of the CB1 receptor reduced immune system activation & promoted a healthy response

The cannabinoid WIN55212-2 impairs peanut allergic sensitization and promotes the generation of allergen-specific regulatory T cells

https://pubmed.ncbi.nlm.nih.gov/34995385/

In white blood cells infected by HIV, activating the CB2 receptor reduced neurotoxicity

Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages

https://pubmed.ncbi.nlm.nih.gov/34996989/

In rats, effects of sex, species & age on pharmacology of THC

Sex, species and age: Effects of rodent demographics on the pharmacology of ∆ 9-tetrahydrocanabinol

https://pubmed.ncbi.nlm.nih.gov/32810571/

The main finding is that THC’s effects are stronger in females.