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Research Roundup: Feb 7, 2022




Best of the Week...


Dr. Dustin Sulak’s primer on CBD & drug interactions

https://healer.com/a-patients-guide-to-cbd-and-drug-interactions/

“CBD is unlikely to cause drug interactions at low and moderate doses used by most consumers of artisanal products. Drug interactions reported in the scientific literature most often occur at very high doses used in clinical trials of epilepsy and other conditions.”

related: In a case study, warfarin & a combination of THC & CBD saw no interaction

Case report: Medical cannabis-warfarin drug-drug interaction

https://pubmed.ncbi.nlm.nih.gov/35012687/

A scientist shares her personal experience with using cannabis & CBD to treat her son’s severe tics

https://www.cannabisclinicians.org/2021/12/15/tic-disorder-management-with-cannabis-studies-and-patient-reports-tourette-syndrome/

In older medical cannabis users, CBD oils are the most common type being used & people report them helpful for pain, sleep, mood, a reduced use of opioids & a reduced use of benzodiazepines

Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects

https://pubmed.ncbi.nlm.nih.gov/34940961/

A survey of medical cannabis users finds their most prevalent reasons for use to be pain, sleep, headaches/migraines, appetite, nausea, anxiety, depression, PTSD, substance addictions & psychosis

Prevalence and self-reported reasons of cannabis use for medical purposes in USA and Canada

https://pubmed.ncbi.nlm.nih.gov/35020045/

This review looks at the use of CBD for psychiatric disorders

A scoping review of the use of cannabidiol in psychiatric disorders

https://pubmed.ncbi.nlm.nih.gov/34952255/

In nude rats exposed to UV radiation, topical CBD lowered proinflammatory molecules in the skin, dramatically increased the anti-inflammatory LPXA4 & increased antioxidant capacity

Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol

https://pubmed.ncbi.nlm.nih.gov/34445404/

In an animal model of Parkinson’s disease, treatment with CBD caused less neural degeneration, less neuroinflammation & an improvement in motor performance

Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease

https://pubmed.ncbi.nlm.nih.gov/34445626/

In a mouse model of stroke, pretreatment with CBD lessened oxidative stress & cell death

Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats

https://pubmed.ncbi.nlm.nih.gov/35031355/


Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In 3 young patients with Rasmussen encephalitis (a rare disorder of increasing chronic inflammation of one hemisphere of the brain that commonly causes seizures), CBD caused a positive effect when combined with their current anti-seizure drugs

Is cannabidiol worth a trial in Rasmussen encephalitis?

https://pubmed.ncbi.nlm.nih.gov/35093803/

One thing studying cannabinoids has taught me is about a host of rare diseases. So often, after everything else has been tried for these strange under-studied disorders, it’s CBD or THC that finally give relief.

An analysis of medical cannabis patients finds that it helps them with generalized anxiety disorder

UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder

https://pubmed.ncbi.nlm.nih.gov/34937473/

and for chronic pain conditions, THC & CBD improved pain scores as well as quality of life

UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions

https://pubmed.ncbi.nlm.nih.gov/34937477/

Here’s the summary study of their entire analysis

An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry

https://pubmed.ncbi.nlm.nih.gov/35073160/

This analysis looks at how chronic pain patients utilize medical cannabis products

A mixed methods analysis of cannabis use routines for chronic pain management

https://pubmed.ncbi.nlm.nih.gov/35016733/

“THC-rich products were typically used at night, while CBD-rich products were more often used during the day.”

This single-center prospective study found that medical cannabis helped to reduce opioid use in chronic pain patients

Medical Cannabis Used as an Alternative Treatment for Chronic Pain Demonstrates Reduction in Chronic Opioid Use - A Prospective Study

https://pubmed.ncbi.nlm.nih.gov/35051158/

In an analysis of prescription data, the use of Sativex (a 1:1 THC:CBD medicine) caused substantial reductions in opioid use

Possible opioid-saving effect of cannabis-based medicine using individual-based data from the Norwegian Prescription Database

https://pubmed.ncbi.nlm.nih.gov/34559439/

A survey of pregnant women finds that they use cannabis for may reasons, but particularly for symptom management

Reasons for cannabis use during pregnancy and lactation: a qualitative study

https://pubmed.ncbi.nlm.nih.gov/34930765/

In women with PTSD, their genetic variant of FAAH (the enzyme that breaks down anandamide) influences their response to fear

The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

https://pubmed.ncbi.nlm.nih.gov/34952353/

This study of women with endometriosis looked at how their endocannabinoid levels were related to their pain & disease state

Association of endocannabinoids with pain in endometriosis

https://pubmed.ncbi.nlm.nih.gov/34001768/

A twin study found that using cannabis once a week had no association with poorer physical health

The effects of cannabis use on physical health: A co-twin control study

https://pubmed.ncbi.nlm.nih.gov/34871975/



Recent Reviews


This review looks at how CBD helps those with childhood epilepsy via modulation of the neuronal channels for sodium, potassium & calcium

Channelopathy of Dravet Syndrome and Potential Neuroprotective Effects of Cannabidiol

https://pubmed.ncbi.nlm.nih.gov/34992485/

This review & analysis looks at the efficacy of topical cannabinoids for pain in animal models

Efficacy of topical cannabinoids in the management of pain: a systematic review and meta-analysis of animal studies

https://pubmed.ncbi.nlm.nih.gov/35012994/

This review covers the role of FAAH inhibitors for treating Alzheimer’s disease

The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease

https://pubmed.ncbi.nlm.nih.gov/34931308/

Because cannabinoids have been found helpful in treating bladder problems & cystitis, this review looks at finding endocannabinoid biomarkers as a way to look for urinary tract problems

Components of the Endogenous Cannabinoid System as Potential Biomarkers for Interstitial Cystitis/Bladder Pain Syndrome

https://pubmed.ncbi.nlm.nih.gov/35054185/

A review article of CBD hemp extracts for the health of companion animals (pets)

HEMP – ITS USE IN PREVENTION AND TREATMENT OF DISEASES OF COMPANION ANIMALS

https://www.researchgate.net/profile/Jagoda-Kepinska-Pacelik/publication/357017484_Hemp_-_its_use_in_prevention_and_treatment_of_diseases_of_companion_animals/links/61b87fa61d88475981ead389/Hemp-its-use-in-prevention-and-treatment-of-diseases-of-companion-animals.pdf



Preclinical Research & Cannabinoid Chemistry


In mice, a combination of CBD & swimming training protected their hearts

Effect of eight weeks of swimming training and consumption of CBD oil on the expression of NF-kB and 5­HT1A genes in heart tissue of rats with myocardial infraction

https://ebnesina.ajaums.ac.ir/browse.php?a_id=986&sid=1&slc_lang=en

In rats addicted to methamphetamine, CBD caused protection of their hearts

Cannabidiol Attenuates Methamphetamine-Induced Cardiac Inflammatory Response and Necrosis through The PKA/CREB Signaling Pathway

https://www.researchsquare.com/article/rs-1159875/v1

In dogs being fed CBD treats, it did not lower their immune response to a novel antigen

Feeding treats containing cannabidiol (CBD) did not alter canine immune response to immunization with a novel antigen

https://pubmed.ncbi.nlm.nih.gov/34953408/

In two mouse models of infantile seizures, CBD caused anticonvulsive effects without impairment of motor skills

Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats

https://pubmed.ncbi.nlm.nih.gov/35008517/

In stem cells, CBD helped to promote differentiation via the PPARγ receptors that control genetic transcription

Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis

https://pubmed.ncbi.nlm.nih.gov/35026188/

In colon cancer cells, using a novel light therapy to kill cancer cells combined well with CBD

Synthesis of a novel nanobioconjugate for targeted photodynamic therapy of colon cancer enhanced with cannabidiol

https://pubmed.ncbi.nlm.nih.gov/35070080/

In breast cancer cells, CBD suppressed the growth of new blood vessels as well as their stem cell-like properties

Cannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by Downregulation of Hypoxia-Inducible Factors-1α

https://pubmed.ncbi.nlm.nih.gov/34830821/

In the monkey model of HIV, the common symptom of gingivitis is helped by THC which causes an anti-inflammatory effect as well as improvement in the types of bacteria in the oral cavity

Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome

https://pubmed.ncbi.nlm.nih.gov/34954656/

In two rat models of schizophrenia, early blockade of the CB1 receptor inhibited their symptoms via the increasing of 2-AG levels

Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia

https://pubmed.ncbi.nlm.nih.gov/35053256/

In blood immune cells, activating the CB2 receptors helped to lower inflammation

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells

https://pubmed.ncbi.nlm.nih.gov/35011295/

In mice, the endocannabinoidome’s control of energy intake & processing might be mediated partially by the liver peptide LEAP2

Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome\

https://pubmed.ncbi.nlm.nih.gov/35011234/

In rats taking cocaine and/or alcohol, they experienced alterations to their GABA, glutamate & endocannabinoid systems

The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats

https://pubmed.ncbi.nlm.nih.gov/34965406/

In a rat model of diabetes, treatment with Vitamin D seems to help partially via the CB1 receptors of the colon

Vitamin D mitigates diabetes-associated metabolic and cognitive dysfunction by modulating gut microbiota and colonic cannabinoid receptor 1

https://pubmed.ncbi.nlm.nih.gov/34942358/

In a mouse eye cell model of glaucoma, CBN caused neuroprotection of the optic nerve cells, protected from changes in the extracellular matrix & normalized intraocular pressure

Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma

https://pubmed.ncbi.nlm.nih.gov/34921975/

In rats with a flap of their skin cut (a model for surgical procedures), treatment with the drug sumatriptan seemed to be mediated by the CB2 receptors

Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target

https://pubmed.ncbi.nlm.nih.gov/34929701/

In mice with blocked bile flow, blocking the CB1 receptor showed positive metabolic changes as well as lessening liver damage, inflammation & carcinogenesis

Pharmacological Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4 -/- Mice

https://pubmed.ncbi.nlm.nih.gov/34954190/

In mice formerly addicted to cocaine, a synthetic negative allosteric modulator of the CB1 receptor significantly reduced the reinstatement of their cocaine seeking behavior

Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior

https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c01432