Best of the Week...
Dr. Dustin Sulak’s primer on CBD & drug interactions
“CBD is unlikely to cause drug interactions at low and moderate doses used by most consumers of artisanal products. Drug interactions reported in the scientific literature most often occur at very high doses used in clinical trials of epilepsy and other conditions.”
related: In a case study, warfarin & a combination of THC & CBD saw no interaction
Case report: Medical cannabis-warfarin drug-drug interaction
A scientist shares her personal experience with using cannabis & CBD to treat her son’s severe tics
In older medical cannabis users, CBD oils are the most common type being used & people report them helpful for pain, sleep, mood, a reduced use of opioids & a reduced use of benzodiazepines
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects
A survey of medical cannabis users finds their most prevalent reasons for use to be pain, sleep, headaches/migraines, appetite, nausea, anxiety, depression, PTSD, substance addictions & psychosis
Prevalence and self-reported reasons of cannabis use for medical purposes in USA and Canada
This review looks at the use of CBD for psychiatric disorders
A scoping review of the use of cannabidiol in psychiatric disorders
In nude rats exposed to UV radiation, topical CBD lowered proinflammatory molecules in the skin, dramatically increased the anti-inflammatory LPXA4 & increased antioxidant capacity
Changes in Phospholipid/Ceramide Profiles and Eicosanoid Levels in the Plasma of Rats Irradiated with UV Rays and Treated Topically with Cannabidiol
In an animal model of Parkinson’s disease, treatment with CBD caused less neural degeneration, less neuroinflammation & an improvement in motor performance
Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease
In a mouse model of stroke, pretreatment with CBD lessened oxidative stress & cell death
Antioxidant and anti-apoptotic effects of cannabidiol in model of ischemic stroke in rats
Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In 3 young patients with Rasmussen encephalitis (a rare disorder of increasing chronic inflammation of one hemisphere of the brain that commonly causes seizures), CBD caused a positive effect when combined with their current anti-seizure drugs
Is cannabidiol worth a trial in Rasmussen encephalitis?
One thing studying cannabinoids has taught me is about a host of rare diseases. So often, after everything else has been tried for these strange under-studied disorders, it’s CBD or THC that finally give relief.
An analysis of medical cannabis patients finds that it helps them with generalized anxiety disorder
UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder
and for chronic pain conditions, THC & CBD improved pain scores as well as quality of life
UK Medical Cannabis registry: an analysis of clinical outcomes of medicinal cannabis therapy for chronic pain conditions
Here’s the summary study of their entire analysis
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry
This analysis looks at how chronic pain patients utilize medical cannabis products
A mixed methods analysis of cannabis use routines for chronic pain management
“THC-rich products were typically used at night, while CBD-rich products were more often used during the day.”
This single-center prospective study found that medical cannabis helped to reduce opioid use in chronic pain patients
Medical Cannabis Used as an Alternative Treatment for Chronic Pain Demonstrates Reduction in Chronic Opioid Use - A Prospective Study
In an analysis of prescription data, the use of Sativex (a 1:1 THC:CBD medicine) caused substantial reductions in opioid use
Possible opioid-saving effect of cannabis-based medicine using individual-based data from the Norwegian Prescription Database
A survey of pregnant women finds that they use cannabis for may reasons, but particularly for symptom management
Reasons for cannabis use during pregnancy and lactation: a qualitative study
In women with PTSD, their genetic variant of FAAH (the enzyme that breaks down anandamide) influences their response to fear
The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD
This study of women with endometriosis looked at how their endocannabinoid levels were related to their pain & disease state
Association of endocannabinoids with pain in endometriosis
A twin study found that using cannabis once a week had no association with poorer physical health
The effects of cannabis use on physical health: A co-twin control study
Recent Reviews
This review looks at how CBD helps those with childhood epilepsy via modulation of the neuronal channels for sodium, potassium & calcium
Channelopathy of Dravet Syndrome and Potential Neuroprotective Effects of Cannabidiol
This review & analysis looks at the efficacy of topical cannabinoids for pain in animal models
Efficacy of topical cannabinoids in the management of pain: a systematic review and meta-analysis of animal studies
This review covers the role of FAAH inhibitors for treating Alzheimer’s disease
The role of fatty acid amide hydrolase enzyme inhibitors in Alzheimer's disease
Because cannabinoids have been found helpful in treating bladder problems & cystitis, this review looks at finding endocannabinoid biomarkers as a way to look for urinary tract problems
Components of the Endogenous Cannabinoid System as Potential Biomarkers for Interstitial Cystitis/Bladder Pain Syndrome
A review article of CBD hemp extracts for the health of companion animals (pets)
HEMP – ITS USE IN PREVENTION AND TREATMENT OF DISEASES OF COMPANION ANIMALS
Preclinical Research & Cannabinoid Chemistry
In mice, a combination of CBD & swimming training protected their hearts
Effect of eight weeks of swimming training and consumption of CBD oil on the expression of NF-kB and 5HT1A genes in heart tissue of rats with myocardial infraction
In rats addicted to methamphetamine, CBD caused protection of their hearts
Cannabidiol Attenuates Methamphetamine-Induced Cardiac Inflammatory Response and Necrosis through The PKA/CREB Signaling Pathway
In dogs being fed CBD treats, it did not lower their immune response to a novel antigen
Feeding treats containing cannabidiol (CBD) did not alter canine immune response to immunization with a novel antigen
In two mouse models of infantile seizures, CBD caused anticonvulsive effects without impairment of motor skills
Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats
In stem cells, CBD helped to promote differentiation via the PPARγ receptors that control genetic transcription
Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARγ by inducing lipogenesis but not lipolysis
In colon cancer cells, using a novel light therapy to kill cancer cells combined well with CBD
Synthesis of a novel nanobioconjugate for targeted photodynamic therapy of colon cancer enhanced with cannabidiol
In breast cancer cells, CBD suppressed the growth of new blood vessels as well as their stem cell-like properties
Cannabidiol Suppresses Angiogenesis and Stemness of Breast Cancer Cells by Downregulation of Hypoxia-Inducible Factors-1α
In the monkey model of HIV, the common symptom of gingivitis is helped by THC which causes an anti-inflammatory effect as well as improvement in the types of bacteria in the oral cavity
Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome
In two rat models of schizophrenia, early blockade of the CB1 receptor inhibited their symptoms via the increasing of 2-AG levels
Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia
In blood immune cells, activating the CB2 receptors helped to lower inflammation
Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells
In mice, the endocannabinoidome’s control of energy intake & processing might be mediated partially by the liver peptide LEAP2
Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome\
In rats taking cocaine and/or alcohol, they experienced alterations to their GABA, glutamate & endocannabinoid systems
The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats
In a rat model of diabetes, treatment with Vitamin D seems to help partially via the CB1 receptors of the colon
Vitamin D mitigates diabetes-associated metabolic and cognitive dysfunction by modulating gut microbiota and colonic cannabinoid receptor 1
In a mouse eye cell model of glaucoma, CBN caused neuroprotection of the optic nerve cells, protected from changes in the extracellular matrix & normalized intraocular pressure
Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma
In rats with a flap of their skin cut (a model for surgical procedures), treatment with the drug sumatriptan seemed to be mediated by the CB2 receptors
Involvement of cannabinoid type 2 (CB2) receptors in the favorable effects of sumatriptan on the random-pattern skin flap survival in rats: a novel potential target
In mice with blocked bile flow, blocking the CB1 receptor showed positive metabolic changes as well as lessening liver damage, inflammation & carcinogenesis
Pharmacological Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4 -/- Mice
In mice formerly addicted to cocaine, a synthetic negative allosteric modulator of the CB1 receptor significantly reduced the reinstatement of their cocaine seeking behavior
Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior
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