Best of cannabinoid science this week...
In a survey of Dutch people with a brain tumor, 19% used cannabis for symptom relief or effect on the tumor & they self-reported “sleep, anxiety, worrying, and depressive symptoms most frequently improved”
Cannabis use among Dutch patients with a primary brain tumor
On CBD for drug-resistant epilepsy, a meta-analysis of 16 studies covering 668 participants found a “statistically significant seizure reduction”
The use of cannabidiol as adjunctive therapy in adult patients with drug-resistant epilepsy: a systematic review and meta-analysis
In a memory study of healthy adults, CBD did not impair learning or memory
Oral cannabidiol did not impair learning and memory in healthy adults
For postoperative pain, a review of five studies on using cannabinoids
Cannabinoids for Acute Postoperative Pain Management: A Systematic Review and Meta-Analysis of Clinical Trials
On gastrointestinal health, a review of using the cannabinoids
Phytocannabinoids and Their Effects on Gastrointestinal System Health
For veterinary medicine, an editorial & advice on the use of cannabinoids
Editorial: Use of Cannabis Derivatives in Veterinary Medicine
https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1539422/abstract
On electroacupuncture, a review of the involvement of the endocannabinoid system (nice charts)
Research progress regarding endocannabinoid system involvement in pain modulation and electroacupuncture analgesia
In rodents & rabbits, cannabis extract had a favorable safety profile for both acute & prolonged toxicity studies
Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs
In rats, cannabis smoke & oral THC enhanced working memory in the aged but not young adults
Cannabis smoke and oral Δ9THC enhance working memory in aged but not young adult subjects
In a tissue & mouse model of heart injury from the chemotherapy treatment doxorubicin, CBD caused cardioprotective effects via the Hippo pathway
Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway
In a mouse model of colitis, THC at the highest dose significantly improved colitis markers while THC at a lower dose combined with CBD (or the CB1 allosteric modulator ZCZ011)“significantly alleviated colitis markers, restored colon integrity and reestablished GLP-1 homeostasis”
Enhancing Tetrahydrocannabinol’s Therapeutic Efficacy in Inflammatory Bowel Disease: The Roles of Cannabidiol and the Cannabinoid 1 Receptor Allosteric Modulator ZCZ011
In a rat model of renal toxicity, cannabis extract caused remarkably decreased inflammation & a restoration of renal biomarkers almost close to the normal range
Therapeutic Potential of Cannabis sativa Extract in Mitigating Diclofenac-Induced Renal Toxicity in WistarRats
In a rat model of liver damage, the endocannabinoid oleoylethanolamide used 258 targets to protect the liver including by suppressing Wnt3a/β-catenin & activating PGC-1α signaling
The PPAR-α agonist oleoyethanolamide (OEA) ameliorates valproic acid-induced steatohepatitis in rats via suppressing Wnt3a/β-catenin and activating PGC-1α: Involvement of network pharmacology and molecular docking
In the bacteria Staphylococcus aureus, the terpene beta-caryophyllene enhanced the action of ampicillin, perhaps by its inhibition of efflux pumps (which move unwanted proteins out of cells)
ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene
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