Best of cannabinoid science this week...
In a survey of women with inflammatory bowel disease, they reported CBD improved appetite & decreased IBD-related pain & nausea
The Perceived Effectiveness of Cannabidiol on Adult Women with Inflammatory Bowel Disease
In children with autism experiencing severe behavioral symptoms, CBD reduced core symptoms (irritability, social withdrawal, hyperactivity, restricted & repetitive behavior), improved quality of life for patients & families & reduced psychotropic medication in 40% of the cases
Purified cannabidiol leads to improvement of severe treatment-resistant behavioral symptoms in children with autism spectrum disorder
In a survey of people with pain, those with neuropathic pain used significantly more THC & THC/CBD products than those with non-neuropathic pain
Cannabis Use in Adults with Neuropathic versus Non-Neuropathic Pain
For the dosing of CBD in epilepsy, a model for finding the best dose in combination with stiripentol
DOSE PREDICTION OF STIRIPENTOL AND CANNABIDIOL (CBD) IN COMBINATION TREATMENT REGIMEN FOR EPILEPSY BASED ON AN AVERAGE CONCENTRATION AT THE STEADY STATE (CAV,SS) USING A PHYSIOLOGICALLY-BASED PHARMACOKINETIC (PBPK) MODEL IN AGE- VARYING PATIENTS
A review of the CB2 receptor in neurodegenerative & psychiatric conditions (great charts!)
A comprehensive review of the multifaceted role of cannabinoid receptor type 2 in neurodegenerative and neuropsychiatric disorders
For sleep & substance use disorders, a review of the last 25 years of CB1 & CB2 drugs
Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years
In a mouse model of endurance exercise, CBD reshaped their gut microbiome to improve running performance
Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
In mouse blood stem cells damaged by radiation (such as occurs in the bone marrow with cancer treatments), CBD restored their stemness via the Atf2-Lrp6 axis
Cannabidiol restores hematopoietic stem cell stemness in mouse through Atf2-Lrp6 axis after acute irradiation
In a rat model of methamphetamine use disorder, CBD reduced methamphetamine-seeking behavior via dopamine receptors in the ventral tegmental area (a brain region regulating reward, memory, learning & addiction)
Involvement of D2-like dopamine receptors within the ventral tegmental area in the cannabidiol's inhibitory effects on the methamphetamine-seeking behavior
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