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Research Roundup: Feb 21, 2023



Best of cannabinoid science this week...


A review of using the cannabinoids for pain, especially CBD

Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies


A review of the widespread antioxidant effects of CBD & THC as well as the many diseases this relates to

Cannabinoids in the Modulation of Oxidative Signaling


A review of using CBD for brain diseases

Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration


A study of how different CBD formulations get delivered to the various regions of the brain

Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain


A huge multi-center study on the efficacy of using CBD for epilepsy

Real-world data on cannabidiol treatment of various epilepsy subtypes: A retrospective, multicenter study


On the possibility of using CBD for sickle cell anemia Is CBD ready for prime time in sickle cell disease? https://ashpublications.org/blood/article/141/2/132/494014/Is-CBD-ready-for-prime-time-in-sickle-cell-disease


In a mouse model of fetal alcohol syndrome, CBD helped with their emotional & cognitive disturbances Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder https://pubmed.ncbi.nlm.nih.gov/36642113/


In a rat model of depression, CBD modulates changes in the prefrontal cortex to the microRNAs (cellular control machinery of protein production) & that this help for depression is mediated by a serotonin receptor Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression https://pubmed.ncbi.nlm.nih.gov/36768376/


On skin, CBD & CBG kill harmful microbials while sparing the skin’s microbiome Cannabidiol and Cannabigerol Exert Antimicrobial Activity without Compromising Skin Microbiota https://pubmed.ncbi.nlm.nih.gov/36768709/

And in skin stem cells, a look at the pathways CBD uses to enhance the skin barrier & reduce oxidative stress Cannabidiol mediates epidermal terminal differentiation and redox homeostasis through aryl hydrocarbon receptor (AhR)-dependent signaling https://pubmed.ncbi.nlm.nih.gov/36725458/


On how CBD regulates the calcium channels that underlie the mechanism of pain Differential regulation of Cav 3.2 and Cav 2.2 calcium channels by CB1 receptors and cannabidiol https://pubmed.ncbi.nlm.nih.gov/36647671/


In elderly horses, CBD reduced their production of inflammatory cytokines with no negative side effects The effects of cannabidiol on immune function and health parameters in senior horses https://www.sciencedirect.com/science/article/abs/pii/S016524272300003X

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