Best of cannabinoid science this week...
For Alzheimer’s, a review of the advantages of using multiple cannabinoids for treatment
Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease
A review of Spain’s CBD program finds help for children & adults with epilepsy Outcomes from a Spanish Expanded Access Program on cannabidiol treatment in pediatric and adult patients with epilepsy https://pubmed.ncbi.nlm.nih.gov/36327646
And in healthy humans, 750 mg of CBD did not change how the body processed methylphenidate (a drug commonly used in childhood epilepsy) The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects https://www.karger.com/Article/FullText/527189
In healthy humans, a low dose of dronabinol (pharmaceutical THC) increased blood flow to their retina but not oxygenation
The Effect of Orally Administered Low-Dose Dronabinol on Retinal Blood Flow and Oxygen Metabolism in Healthy Subjects
In horses, a thesis project on how CBD moves through their bodies when given a single dose or chronically for 8 weeks Pharmacokinetics of CBD Supplementation in Horses: Single Dose vs. Long-Term Feeding https://digitalcommons.murraystate.edu/scholarsweek/Fall2022/HON/14
A survey of pet owners find “positive effects, such as improved well-being, increased activity, and reduced pain” Use of cannabidiol products by pet owners in Slovenia: a survey-based study https://www.researchgate.net/publication/364995637_Use_of_cannabidiol_products_by_pet_owners_in_Slovenia_a_survey-based_study
In dogs with osteoarthritis, this thesis project found no difference in improved pain results between CBD & water-soluble CBD (aka nano-CBD, thought to have better bioavailability)
Comparison of Water-Soluble CBD and CBD Oil as an Anti-Inflammatory in Canines with Osteoarthritis
https://digitalcommons.murraystate.edu/scholarsweek/Fall2022/HON/3
In a rat model of tardive dyskinesia (repetitive movement of facial muscles), CBD helped the standard treatment of haloperidol to work better The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration https://pubmed.ncbi.nlm.nih.gov/36328984
In a rat model of Parkinson’s, cannabis improved their motor control via an increase in synaptic plasticity
Marijuana improved motor impairments and changes in synaptic plasticity-related molecules in the striatum in 6-OHDA-treated rats
In a mouse model of methamphetamine addiction, they saw help from a 1:1 CBD:THC treatment A 1:1 ratio of cannabidiol: tetrahydrocannabinol attenuates methamphetamine conditioned place preference in mice: A prospective study of antidopaminergic mechanism https://pubmed.ncbi.nlm.nih.gov/36336144
In a mouse model of chronic itchy skin, electroacupuncture helps via the brain’s CB1 receptors & the lowering of serotonin levels by the control of both GABA & glutamate (the brain’s primary inhibitory & excitatory neurotransmitters respectively) Electroacupuncture reduces chronic itch via cannabinoid CB1 receptors in the ventrolateral periaqueductal gray https://pubmed.ncbi.nlm.nih.gov/36133809