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Research Roundup: Dec 5, 2023



Best of cannabinoid science this week...


The first randomized control trial on CBD for dental pain found significant & quick pain reduction

Cannabidiol as an Alternative Analgesic for Acute Dental Pain


In a pilot study of CBD for acute bipolar depression, 300 milligrams of CBD per day over 8 weeks reduced scores of depression Cannabidiol as an Adjunctive Treatment for Acute Bipolar Depression: A Pilot Study https://pubmed.ncbi.nlm.nih.gov/37920963/


The ability of CBD to lower blood pressure in people with hypertension seems to be mediated by its reduction of inflammatory cytokines Antihypertensive effects of CBD are mediated by altered inflammatory response: A sub-study of the HYPER-H21-4 trial https://www.sciencedirect.com/science/article/pii/S1756464623004735


In people hospitalized with venous thromboembolism (blood clots), the users of cannabis had lower mortality rates, in-hospital complications, shorter hospital stays & slightly reduced cost

Venous thromboembolism and cannabis consumption, outcomes among hospitalized patients in the United States: A nationwide analysis


A small study of the simultaneous effects from CBD & caffeine found that they really didn't interact that much A preliminary investigation of the simultaneous effects of cannabidiol and caffeine https://pubmed.ncbi.nlm.nih.gov/37917507/


In a survey of fibromyalgia patients, 15% report using cannabinoids Significant use of non-evidence-based therapeutics in a cohort of Australian fibromyalgia patients https://pubmed.ncbi.nlm.nih.gov/37872879/


For epilepsy, a review of 50 studies on the use of CBD

Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis


Canine immune cells have high levels of cannabinoid receptors & are very sensitive to their effects Canine immune cells express high levels of CB1 and CB2 cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent https://pubmed.ncbi.nlm.nih.gov/37931433/


In a mouse model of complex regional pain syndrome, local injections of CBD reduced the hypersensitivity to pain Complex Regional Pain Syndrome Type I: Evidence for the CB1 and CB2 Receptors Immunocontent and Beneficial Effect of Local Administration of Cannabidiol in Mice https://www.liebertpub.com/doi/abs/10.1089/can.2023.0093


In rats with bacteria in their pancreas, CBD protected via several different measures Cannabidiol Mitigates Lipopolysaccharide-Induced Pancreatic Pathology: A Promising Therapeutic Strategy https://pubmed.ncbi.nlm.nih.gov/37903028/


In a mouse model of malaria, CBD was the strongest at increasing life expectancy Investigation of the Efficacy of Cinnamaldehyde, Cannabidiol and Eravacycline in a Malaria Model https://pubmed.ncbi.nlm.nih.gov/37885389/


In neural cells of the hippocampus (memory center of the brain), CBD promoted neurite (protrusions) growth, elongation & arborization as well as accelerating the process of axon specification

Promoting effects of cannabidiol on neurite growth and neuronal development in neuron-astrocyte sandwich coculture


In human & rodent cells, CBD improved the expression of vitamin D3 receptors, inflammation, cell growth, tissue elasticity & enhanced mitochondrial bioenergetics Cannabidiol (CBD) Upregulates Vitamin D3 Receptors (VDRs) Expression That Modulates Cytokines (TNF-α, IL-6), Tissue Elasticity, Cellular Senescence, and Mitochondrial ATP Generation in Human and Rodent Cell Lines https://www.dovepress.com/cannabidiol-cbd-upregulates-vitamin-d3-receptors-vdrs-expression-that--peer-reviewed-fulltext-article-NDS


In rats, the pharmacokinetics of CBD into various tissues Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue https://pubmed.ncbi.nlm.nih.gov/35631242/


In female rats taking contraception, giving them cannabinoids did not significantly alter their motor & cognitive skills or induce anxiety or depressive states Behavioral characterization of co-exposure to cannabinoids and hormonal contraceptives in female rats https://pubmed.ncbi.nlm.nih.gov/37926338/


In a mouse model of obesity, the terpene beta caryophyllene caused weight loss & improve the lipid balance via the CB2 receptor, SIRT1/PGC-1α/PPARγ signaling pathway & SIRT1/AMPK signaling pathway Mechanisms of weight-loss effect in obese mice by the endogenous cannabinoid receptor 2 agonist beta-caryophyllene https://pubmed.ncbi.nlm.nih.gov/37919194/

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