Research Roundup: May 13, 2025
- Lex Pelger
- May 13
- 2 min read
Best of cannabinoid science this week...
Across 19 hospitals of Thai children with drug-resistant epilepsy, CBD oil caused consistent improvements in seizures over the course of a year
Adjunctive CBD-Enriched Cannabis Oil for Pediatric Drug-Resistant Epilepsy in Thailand
“Most seizure types responded positively to treatment, except for complex motor seizures. The effective CBD dose varied within a range of 1-15 mg/kg/day. Adverse events were reported in 92% of patients, predominantly mild (95%) and including somnolence, increased liver enzymes, anorexia, and irritability. Thirty-three patients discontinued CBD, with 57% due to intolerable adverse events, 30% ineffectiveness, and 12% non-compliance.”
In caregiver reports of severe pediatric epilepsy, the majority said CBD improved seizure frequency & severity as well as alertness, cognition & executive function, though 26% reported worsening in one or more aspects of the patient burden, but overall, 94% planned to continue CBD treatment
Caregiver-Reported Non-Seizure and Seizure Outcomes With Cannabidiol and Clobazam in Lennox-Gastaut Syndrome or Dravet Syndrome
In two cases of chronic pain from fibromyalgia, CBD caused significant improvement & lowered the use of other medications
Effective treatment of fibromyalgia-associated chronic pain with cannabidiol (Epidyolex) in two cases
In a case report of a person with chronic pain from a spinal cord injury, a 1:1 THC:CBD formulation allowed them to successfully taper off opioids & reduce anxiety symptoms
Case Report: Formulation of Balanced Medicinal Cannabis in the Tapering of Opioids in Non-Cancer Chronic Pain
In Germany, people sought over-the-counter CBD products for their health, their pain (general, chronic, muscle & joint pain) & psychological symptoms (sleep disorders, nervousness, anxiety)
Over the Counter CBD Products in Germany: An Exploratory Survey About Consumption Patterns and Health-Related Effects
For pediatric autism, a review of 6 articles found cannabis to cause significant improvements to social responsiveness, communication, daily living & socialization
Cannabis and Cannabinoids use in Children and Adolescents with Autism Spectrum Disorder: a systematic review
In a rat model of neuropathic pain, oral cannabinoid formulations caused improved pain, reduced oxidative stress & lowered inflammation
Oral Cannabinoid Formulation Elevates Sensory Nerve Conduction Velocity and Mitigates Oxidative Stress to Alleviate Neuropathic Pain in Rats
And in a mouse model of pain, cannabis extracts lowered pain sensitivity
Cannabis sativa Extract Modulates Pain Sensitivity in Albino Wistar Rats: Gender and Dose Considerations
In a mouse model of Alzheimer's disease, six weeks of THC improved spatial reference & object recognition memory, reduced Aβ plaques in the hippocampus & cortex & modulated neurogenesis, inflammation & glucose metabolism [German]
Das therapeutische Potential von niedrig dosiertem Δ9-Tetrahydrocannabinol bei der Modulation der Alzheimer-Pathologie im 5xFAD-Mausmodell
[The therapeutic potential of low-dose Δ9-tetrahydrocannabinol in modulating Alzheimer's pathology in the 5xFAD mouse model]
In a roundworm model of aging, a precursor to oleoylethanolamine (the endocannabinoid of satiation) boosted lipolysis, increased oxidative stress resistance & extended lifespan
Oleoylethanolamine precursor triggers lipolysis during Time-Restricted Intermittent Fasting and promotes longevity and healthy aging of Caenorhabditis elegans
Comments