Research Roundup: Dec 16, 2025
- Dec 15, 2025
- 3 min read
Best of cannabinoid science this week...
In women with chronic pain syndromes, an excellent Brazilian study of full-spectrum cannabis extracts with tailored dosages found improvements in pain relief, cognitive function, motor abilities, professional activities & ability, irritability, anxiety, melancholy, fatigue & sleep quality
Full-spectrum cannabis extracts for women with chronic pain syndromes: a real-life retrospective report of multi-symptomatic benefits after treatment with individually tailored dosage schemes
For fibromyalgia, data from the UK Medical Cannabis Registry found cannabis-based medicinal products improved all measures of symptom severity, pain, anxiety & sleep
UK Medical Cannabis Registry: a case series analysing clinical outcomes of medicinal cannabis therapy for fibromyalgia
In people with chronic kidney disease, interviews on how they use cannabinoids to relieve symptoms & on their barriers to use
Patients’ Perspectives and Experiences of Cannabinoids to Manage Symptoms of Chronic Kidney Disease: An In-Depth Interview Study
In people with chronic pain, joining the New York medical cannabis program was associated with significantly reduced opioid prescriptions
Medical Cannabis and Opioid Receipt Among Adults With Chronic Pain
In people with poor sleep, this meta-analysis of six trials found cannabinoids significantly improved sleep quality, especially the non-CBD cannabinoids
Effectiveness of cannabinoids on subjective sleep quality in people with and without insomnia or poor sleep: A systematic review and meta-analysis of randomised studies
For people with cystic fibrosis, public health data found that cannabis use disorder was not associated with 30-day readmission
ASSOCIATION OF CANNABIS USE DISORDER WITH 30-DAY READMISSION RISK IN CYSTIC FIBROSIS EXACERBATION: A NATIONWIDE ANALYSIS
In people with bipolar disorder, their cannabis use had no effect on their average length of hospital admission
Length of hospital admission, cannabis use and associated factors in patients with bipolar disorder
For suicide in older adults, the National Bureau of Economic Research found that the opening of adult-use cannabis dispensaries decreased suicide rates
Marijuana Legalization and Suicides Among Older Adults
In a Dutch survey of non-prescribed medical cannabis use, the most common conditions were chronic pain, sleep disorders, depression & ADHD/ADD
Medicinal use of non-prescribed cannabis: a cross-sectional survey on patterns of use, motives for use, and treatment access in the Netherlands
In dogs with eczema, a combination of PEA & polyunsaturated fatty acids decreased itchiness & skin lesion severity
Clinical evaluation of polyunsaturated fatty acids in combination with palmitoylethanolamide (PEA) in the treatment of signs of atopic dermatitis in dogs:Pilot study
On cannabinoids for mental health & substance use disorders, a review of 28 studies found short-term benefits for autism, schizophrenia & cannabis use disorder
Randomised Controlled Trial Evidence on Medicinal Cannabis for Treatment of Mental Health and Substance Use Disorders: A Scoping Review
In prodromal psychosis (initial symptoms), a review of 22 studies on the ECS as a therapeutic target
The endocannabinoid system as a therapeutic target in prodromal psychosis: From molecular mechanisms to clinical applications
For acne, a review of the efficacy of CBD & hemp extracts (nice charts)
Sustainable Utilisation and Resilience of Industrial Hemp Supply Chains: A Systematic Review of Advancing Skin Health Through Anti-Inflammatory Nutraceuticals for Acne Treatment
In a mouse model of Alzheimer’s disease, inhaled CBD reduced neuroinflammatory markers including TNF-α, IL-1β & IFN-γ via AKT1, TRPV1, & GPR55
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
In a mouse model of chronic kidney disease, oleoylethanolamide (the endocannabinoid of satiation (my video here)) lowered kidney inflammation, scarring & damage while improving function
Uncovering the pleiotropic effects of oleoylethanolamide on obesity-driven chronic kidney disease in mice
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