Research Roundup: Dec 30, 2025
- Lex Pelger
- Dec 30, 2025
- 3 min read
Best of cannabinoid science this week...
For humans running 2 miles, CBD reduced average time by 8% as well as increased feelings of calm & relaxation
The Effects of an Acute Dose of Cannabidiol on Health and Two-Mile Time Trial Performance—A Pilot Study
For sleep quality after starting medical cannabis, global sleep quality scores were higher
Changes in sleep quality during the 12 months following medical cannabis initiation
In head & neck cancer survivors, a survey found the most common reasons for cannabis use were to treat pain, improve sleep, cope with stress & recreation
Characteristics of Cannabis Use Among Head and Neck Cancer Survivors
For cancer-related anorexia, interviews about vaped cannabis found perceived benefits for eating
Benefits and Burdens of Vaporized Botanical Cannabis Flower Bud for Cancer-Related Anorexia: A Qualitative Study of the Experiences of People with Advanced Cancer Enrolled as Inpatients in a Phase I/IIb Clinical Trial and Their Family Carers
For cannabis & alcohol consumption, a new laboratory co-administration test found cannabis self-administration was associated with a significant reduction in number of drinks & had less cravings
Cannabis administration is associated with reduced alcohol consumption: Evidence from a novel laboratory co-administration paradigm
For insomnia, a review of THC & cannabis
Medical cannabis and insomnia: a review
For CBD in neurology, a review found the best evidence for severe treatment-resistant epilepsy & more limited evidence for neuropathic pain, Alzheimer’s & Parkinson’s
Cannabidiol in Neurology: Current Insights and Translational Perspectives
In people with treatment-resistant epilepsy, a review on how to use CBD
Practical approach to the safe use of cannabidiol in patients with refractory epilepsy: a mini review
For Alzheimer’s disease, a review on the endocannabinoid system for managing neuropsychiatric symptoms
The role of the endocannabinoid system in managing Neuropsychiatric Symptoms in Alzheimer's Disease
And in Alzheimer’s disease, a review of how cannabinoids modulate autophagy (cellular recycling)
Exploring cannabinoid modulation on autophagy mechanisms in Alzheimer's disease: A review
For cannabis & chronic musculoskeletal pain, a review of the evidence
The Evidence for Medical Cannabis in Chronic Musculoskeletal Pain Management
In mice with sleep fragmentation, the endocannabinoid oleoylethanolamide reversed the behavioral deficits & enhanced synaptic plasticity
Oleoylethanolamide supplement attenuates postweaning sleep fragmentation-induced social behavioral deficits via inhibiting hippocampal microglial reactivity in adult mice
In a mouse model of neurotoxicity, CBD mitigated anxiety-like behaviors, modulated the oxidative stress response, reduced inflammatory cytokines & improved neural plasticity via BDNF (a key brain growth factor)
Cannabidiol as a Neuroprotective Agent in Acrylamide-Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice
In a mouse model of liver injury, CBD inhibited oxidative stress, inflammation, apoptosis (programmed cellular suicide) & damage to the mitochondria (powerhouse of the cell) via protection of the hepatic mitofusin-2 (MFN2) protein
Cannabidiol attenuates the LPS/D-Galactosamine-induced acute liver injury by inhibiting parkin-mediated ubiquitination of MFN2
In a mouse model of inflammation, CBG lowered inflammatory cytokines
Cannabigerol Exerts In Vivo and In Vitro Anti-Inflammatory Effects via Inhibition of the MAPK and NF-κB Pathways
In a fruit fly model of seizures, CBD caused anticonvulsant activity
Seizure Susceptibility in Drosophila melanogaster is Reduced with CBD and Z. jujube treatment
In human skin exposed to pollution, CBD lowered inflammation, oxidative stress & barrier damage
Cannabidiol Mitigates Pollution-Induced Inflammatory, Oxidative, and Barrier Damage in Ex Vivo Human Skin
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