Research Roundup: May 27, 2025
- Lex Pelger
- 2 days ago
- 2 min read
Best of cannabinoid science this week...
In boys with autism & severe behavior problems, a placebo-controlled randomized clinical trial of 8 weeks of CBD caused clinically evident improvement but also a prominent placebo effect
Cannabidiol (CBD) Treatment for Severe Problem Behaviors in Autistic Boys: A Randomized Clinical Trial
For anxiety, a systematic review of medical cannabis
Medicinal Cannabis in the Management of Anxiety Disorders: A Systematic Review
For palmitoylethanolamide (PEA), a review of its therapeutic potential for neurodegenerative disorders, pain & immune system dysregulation
Palmitoylethanolamide: A Multifunctional Molecule for Neuroprotection, Chronic Pain, and Immune Modulation
For CBD & the immune system, a review of its preclinical & clinical effects
Cannabidiol as an Immune Modulator: A Comprehensive Review
In aging mice, CBN improved their spatial memory (with more pronounced effects in females) partially via the mitochondria (powerhouse of the cell)
Cannabinol (CBN) Alleviates Age-Related Cognitive Decline by Improving Synaptic and Mitochondrial Health
And on CBN's binding sites for neuroprotection, specifically the key mitochondrial target isocitrate dehydrogenase 2 (IDH2)
Affinity-Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor-Independent Neuroprotection
In a mouse model of Alzheimer's disease, CBD improved short- & long-term memory, decreased plaque aggregation & reduced their transport, increased viability of the neurons, reduced neuroinflammation & shifted to a more neuroprotective phenotype of the microglia (guardian immune cells of the brain)
Cannabidiol as a Multifaceted Therapeutic Agent: Mitigating Alzheimer’s Disease Pathology and Enhancing Cognitive Function
In a mouse model of chronic stress, a very low dose of CBD reversed symptoms & caused improvements in the prefrontal cortex & across multiple neurotransmission systems
Low-Dose Cannabidiol Treatment Prevents Chronic Stress-Induced Phenotypes and Is Associated with Multiple Synaptic Changes
In a rat model of stroke, cannabis extracts improved neurological deficits & protected against oxidative stress as well as lung inflammation
Full-spectrum Cannabis sativa extract enhances gut-peripheral organ integrity after experimental ischemic stroke
In mouse models of autism, CBD restored social deficits with gendered effects
Cannabidiol-Induced Recovery of Social Behaviour in Mouse Models of Syndromic Autism
And in a mouse model of autism, CBD improved their social interaction & anxiety levels as well as lowering of oxidative stress
Cannabis Oil Protects Against Valproic Acid–Induced Autism Spectrum Disorder by Reducing Oxidative Stress
In a mouse model of panic induced by venomous snakes, CBD lowered their anti-predatory responses
Unravelling a Potential Therapeutic Effect of Polymeric Lipid-Core Nanoencapsulated Cannabidiol on Anxiety- and Panic-Like Behaviours Elicited by Bothrops jararaca Lancehead Pit Vipers
In a rat model of gastric ulcers, the terpene beta-caryophyllene decreased gastric contractions & protected gastric tissues from oxidative stress, inflammation & apoptosis (programmed cellular suicide)
Investigation of the Protective Effect of Beta Caryophyllene Against Indomethacin-Induced Gastric Ulcer in Rats
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