Best of cannabinoid science this week...
In people with severe knee osteoarthritis, cannabis oil caused significant improvements to pain, activities of daily living & quality of life
Effectiveness of Cannabis Oil as an Adjuvant Therapy in Patients with Severe Knee Osteoarthritis: A Randomized, Double-Blind Study
For migraines, a vaped THC/CBD mixture caused sustained pain relief
Vaporized Cannabis versus Placebo for Acute Migraine: A Randomized Controlled Trial
In people with graft-versus-host disease, Sativex (a 1:1 THC:CBD pharmaceutical spray) caused the majority to have improved symptoms, especially for their muscle cramps
Sativex Oromucosal Spray in Patients with Chronic Graft Versus Host Disease: Effect on Sclerodermal Features and Refractory Muscle Cramps
For fibromyalgia & cannabis, a case series found improvements for pain, insomnia, the performance of daily life activities & quality of life
Effectiveness of Cannabinoids Treatment in Pain Management and Other Fibromyalgia-Associated Symptoms: A Case Series
For arteriovenous malformation (an abnormal tangle of blood vessels causing connection problems between arteries & veins), public health data showed that people using cannabis had a reduced likelihood of extended hospital stays & complications
Evaluating the effects of recreational drug use on ruptured cerebral arteriovenous malformation presentation and in-hospital outcomes: a national inpatient sample analysis
In a Japanese survey of CBN users, people used it the most for sleep, anxiety, depression & fun
How Cannabinol Is Utilized in Japan, a Country with Strict Cannabis Regulations—Its Purposes, Medical Effects, Adverse Events, and Dependence
Public health data on the prescribing of Epidiolex (pharmaceutical CBD isolate)
Cannabidiol prescribing in the United States: An analysis of real-world data
“Among individuals receiving Epidiolex®, 40 % did not have FDA-approved diagnostic indications (LGS/DS/TSC) in the medical record…. Among individuals without LGS/DS/TSC who received Epidiolex®, the most common diagnoses received following the index prescription were unspecified epileptic syndromes (53.8 %), sleep disorders (25.7 %), anxiety disorders (25.9 %), mood disorders (18.6 %) and autism spectrum disorders (10.8 %).”
For neuropathic pain, a review of 13 studies found a significant decrease in neuropathic pain scores after treatment with a cannabinoid
The Use of Cannabinoids in the Treatment of Peripheral Neuropathy and Neuropathic Pain: A Systematic Review
For skin, a review of the cannabinoid’s ability to reduce inflammation, improve moisture retention, cause strong antioxidant effects & improve various skin conditions
Effects of Cannabis sativa Extract on Skin Physiology and Activity
And for acne, a review of the promise of targeting the endocannabinoid system [Spanish]
Sistema Endocannabinoide y su potencial terapéutico para el tratamiento del acne
In a rat model of chronic stress, CBD/CBDA hemp extracts reduced their cognitive impairment, protected their hippocampal neurons, reduced their microglial activation (guardian immune cells of the brain), & reversed HPA axis hyperactivity via cortisol levels
Cannabidiol/cannabidiolic acid-rich hemp (Cannabis sativa L.) extract attenuates cognitive impairments and glial activations in rats exposed to chronic stress
In a mouse model of epilepsy, a study of CBD formulations found the best to be broad-spectrum CBD via inhalation
Optimization of Seizure Prevention by Cannabidiol (CBD
In a rat model of rheumatoid arthritis, CBD reversed the problems in their gut microbiome, leading to improvements in immune cell levels & inhibition of inflammation
Cannabidiol regulates L-carnitine and butyric acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis
In a rat model of sciatic nerve injury, injection of CBD nanoparticles caused enhanced axonal restoration & remyelination as well as improvements to locomotor activities & muscle mass retention
Effectiveness of the injectable hyaluronic acid-based microparticles loaded with cannabidiol on rat sciatic nerve injury model
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