Research Roundup: Aug 26, 2025

Best of cannabinoid science this week...

In people with anxiety, a full-spectrum CBD solution significantly reduced anxiety symptoms as well as improving mood, sleep & quality of life

Clinical and Cognitive Improvement Following Treatment with a Hemp-Derived, Full-Spectrum, High-Cannabidiol Product in Patients with Anxiety: An Open-Label Pilot Study

https://www.mdpi.com/2227-9059/13/8/1874

For chemotherapy-induced peripheral neuropathy (nerve pain), cannabis reduced symptoms & improved quality of life with THC showing greater improvements in burning sensation & cold sensations & the combination of CBD & THC yielding the greatest symptom relief

Comparative Effects of THC and CBD on Chemotherapy-Induced Peripheral Neuropathy: Insights from a Large Real-World Self-Reported Dataset

https://www.mdpi.com/2227-9059/13/8/1921

In people with chronic pain, those who started medical cannabis had significantly decreased opioid consumption as well as disability & insomnia levels

Opioid reduction in patients with chronic non-cancer pain undergoing treatment with medicinal cannabis

https://www.tandfonline.com/doi/abs/10.1080/17581869.2025.2544511

In people with schizophrenia, a cohort analysis found cannabis use associated with a reduced risk for metabolic syndrome including reduced weight, waist circumference, BMI & triglycerides as well as higher HDL

Cannabis Use and Cardiometabolic Risk in Schizophrenia

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5374079

In people with glaucoma, one dose of dronabinol (pharmaceutical THC) increased ocular blood flow & vessel density

Single oral administration of dronabinol increases ocular blood flow in patients with glaucoma

https://onlinelibrary.wiley.com/doi/full/10.1111/aos.17573

In a case report of treatment-resistant chronic pancreatitis (inflammation of the pancreas, often with severe pain), a CBD-rich medical cannabis formulation substantially reduced pain, stopped acute episodes, improved appetite & enhanced quality of life

Medical cannabis for the management of pain in chronic pancreatitis with recurrent exacerbations: a case report

https://link.springer.com/article/10.1186/s42238-025-00303-w

In dogs with osteoarthritis, an extract with CBDA, CBD, THCA & THC lowered their pain scores & improved their osteoarthritis scores

Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral Cannabis sativa Oil Extract, Standardized Based on CBD-A, CBD and THC-A, THC in Canines with Chronic Osteoarthritis

https://www.preprints.org/frontend/manuscript/467de30f34fcfee88e6ba2c558e7e207/download_pub

For multiple sclerosis, this review & meta-analysis of 9 studies found notable improvements for spasticity, particularly over longer durations

Assessing the Role of Cannabis in Managing Spasticity in Multiple Sclerosis: A Systematic Review and Meta-Analysis

https://www.clinicaltherapeutics.com/article/S0149-2918(25)00246-2/abstract

For aging, longevity & cannabinoids, this review of 18 studies found promising preclinical results for “improved lifespan, cognitive function, inflammation, memory, sleep quality, and social interaction” with THC showing potential benefits at low doses & drawbacks at high doses

The impact of cannabis use on ageing and longevity: a systematic review of research insights

https://link.springer.com/article/10.1186/s42238-025-00267-x

For cognitive function in older adults, a review of CBD's effects

Cannabidiol (CBD) and cognitive function in older adults: a mini review

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1646151/abstract

For depression, this review focused on dysregulation of the endocannabinoid system & that many of the most common treatments modulate endocannabinoid levels (nice charts)

Endocannabinoids, depression, and treatment resistance: Perspectives on effective therapeutic interventions

https://www.sciencedirect.com/science/article/pii/S0165178125003440

For atopic dermatitis (eczema), a review on the therapeutic potential of cannabinoids

Therapeutic potential of cannabinoids for treating atopic dermatitis

https://link.springer.com/article/10.1186/s42238-025-00317-4

For cannabinoids & exercise, a review of their combined effects on the brain

Considering the Effects of Cannabinoids and Exercise on the Brain: A Narrative Review

https://www.preprints.org/frontend/manuscript/09eff002eb10c4d2bc73097422f653be/download_pub

For bone healing & fusion, this review found that activating the CB2 receptor or using CBD improved bone production & repair, while activating the CB1 receptor with THC lowered bone-mineral density (though THC was neutral over short time periods)

The Cannabinoid Pharmacology of Bone Healing: Developments in Fusion Medicine

https://www.mdpi.com/2227-9059/13/8/1891

For dentistry, a review of the evidence for cannabinoid medicines

Cannabis: What We Use, Why It Matters, and When It Is Prescribed (Ethics, Policy, and Practice)

https://assets.cureus.com/uploads/review_article/pdf/387847/20250730-113168-hhfik5.pdf

In a rat model of aging, intermittent cannabis use protected the brain & reduced age-related cognitive decline

Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging

https://link.springer.com/article/10.1186/s42238-025-00313-8

In a mouse model of chronic pain, the combination of CBD & the terpene beta-caryophyllene produced pain-killing & antidepressant effects with a significant reduction in neuroinflammation

Phytocannabinoids in Combination: Chronic Pain

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5390901

In a mouse model of social defeat, CBD prevented social avoidance & prevented the increased reward from cocaine induced by social defeat via modulation of the genetic expression of cannabinoid receptors

Cannabidiol prevents social avoidance, potentiation of cocaine reward and gene expression alterations induced by exposure to intermittent social defeat in mice

https://www.sciencedirect.com/science/article/pii/S0028390825003387