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Research Roundup: Aug 23, 2021



Best of the Week...


In frontline healthcare professionals working with COVID-19 patients, 1 month of CBD reduced symptoms of burnout & emotional exhaustion

Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/34387679/


A review of CBD for oxidative stress

Cannabidiol modulation of oxidative stress and signalling

https://portlandpress.com/neuronalsignal/article/doi/10.1042/NS20200080/229491/Cannabidiol-modulation-of-oxidative-stress-and


This review looks at CBD for our pet’s anxiety, pain & inflammation

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

https://www.sciencedirect.com/science/article/abs/pii/S0034528821002538


Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

This expert panel of Colombian psychiatrists suggested CBD for the treatment of the major mental disorders

Colombian consensus of treatment with pure cannabidiol (CBD) in Psychiatry

https://europepmc.org/article/ppr/ppr381442


This review of 16 studies looks at treating osteoarthritis with CBD

Efficacy of Cannabidiol in Treating Osteoarthritis

https://journals.lww.com/jbjsjopa/Abstract/2021/09000/Efficacy_of_Cannabidiol_in_Treating_Osteoarthritis.9.aspx


A review of 15 studies using cannabinoids for dementia

Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: systematic review

https://pubmed.ncbi.nlm.nih.gov/34374269/


This review looks at using the cannabinoids for skin disease & hair regrowth. Plus, they single out CBD as potentially enhancing hair growth

Cannabinoids for skin diseases and hair regrowth

https://pubmed.ncbi.nlm.nih.gov/34363728/



Preclinical Research & Cannabinoid Chemistry

In a mouse model of seizures, this screening identified CBGA, CBDVA & CBGVA as exhibiting anticonvulsant potential

Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy

https://pubmed.ncbi.nlm.nih.gov/34384142/


In human skin cells, the antioxidant ascorbic acid & rutin protected the skin from UV radiation via direct interaction with the ECS

Exogenous Antioxidants Impact on UV-Induced Changes in Membrane Phospholipids and the Effectiveness of the Endocannabinoid System in Human Skin Cells

https://www.mdpi.com/2076-3921/10/8/1260/htm


In bone tissue, CB1 may be a promising target for inflammation of skeletal muscle tissue

The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells

https://www.dovepress.com/the-impact-of-cb1-receptor-on-inflammation-in-skeletal-muscle-cells-peer-reviewed-fulltext-article-JIR


In mice with gastric lesions, targeting the CB1 receptor exerts antioxidant & anti-inflammatory effects

Protective effect of cannabinoids on gastric mucosal lesions induced by water immersion restrain stress in rats

https://ijbms.mums.ac.ir/article_18513_084cafd09209f35965781876e4dd92a0.pdf


In a mouse model of cocaine addiction, the researchers looked at gender differences & the ability of a CB1 antagonist to decrease conditioned place preference (time spent in the drug dispensing area)

Sex differences in cocaine-associated memory: The interplay between CB1, mGluR5, and estradiol

https://www.sciencedirect.com/science/article/abs/pii/S0306453021002407


In rats fed an obesity-inducing diet, the endocannabinoid oleoylethanolamide protected their livers from oxidative stress

Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats

https://www.mdpi.com/2076-3921/10/8/1289/htm


In rats, the CB1 receptors in the hippocampus found to be involved in rewarding & aversion effects which has relevance to addiction

Activation of VTA/CeA/mPFC cannabinoid CB1 receptors induced conditioned drug effects via interacting with hippocampal CAMKII-CREB-BDNF signaling pathway in rats

https://pubmed.ncbi.nlm.nih.gov/34389313/


In rats, the lateral hypothalamus (brain area involved with the body’s response to emotional stress) modulated their cardiovascular response to stress via the CB1 receptors & GABA

Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats

https://pubmed.ncbi.nlm.nih.gov/34373508/


In a cellular culture mimicking the gut microbiome, probiotics engineered to produce butyrate downregulated the ECS

Engineered probiotics modulate the endocannabinoid system

https://www.sciencedirect.com/science/article/pii/S2665906921000040