Best of the Week...
In frontline healthcare professionals working with COVID-19 patients, 1 month of CBD reduced symptoms of burnout & emotional exhaustion
Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial
A review of CBD for oxidative stress
Cannabidiol modulation of oxidative stress and signalling
This review looks at CBD for our pet’s anxiety, pain & inflammation
Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation
Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)
This expert panel of Colombian psychiatrists suggested CBD for the treatment of the major mental disorders
Colombian consensus of treatment with pure cannabidiol (CBD) in Psychiatry
This review of 16 studies looks at treating osteoarthritis with CBD
Efficacy of Cannabidiol in Treating Osteoarthritis
A review of 15 studies using cannabinoids for dementia
Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: systematic review
This review looks at using the cannabinoids for skin disease & hair regrowth. Plus, they single out CBD as potentially enhancing hair growth
Cannabinoids for skin diseases and hair regrowth
Preclinical Research & Cannabinoid Chemistry
In a mouse model of seizures, this screening identified CBGA, CBDVA & CBGVA as exhibiting anticonvulsant potential
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
In human skin cells, the antioxidant ascorbic acid & rutin protected the skin from UV radiation via direct interaction with the ECS
Exogenous Antioxidants Impact on UV-Induced Changes in Membrane Phospholipids and the Effectiveness of the Endocannabinoid System in Human Skin Cells
In bone tissue, CB1 may be a promising target for inflammation of skeletal muscle tissue
The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells
In mice with gastric lesions, targeting the CB1 receptor exerts antioxidant & anti-inflammatory effects
Protective effect of cannabinoids on gastric mucosal lesions induced by water immersion restrain stress in rats
In a mouse model of cocaine addiction, the researchers looked at gender differences & the ability of a CB1 antagonist to decrease conditioned place preference (time spent in the drug dispensing area)
Sex differences in cocaine-associated memory: The interplay between CB1, mGluR5, and estradiol
In rats fed an obesity-inducing diet, the endocannabinoid oleoylethanolamide protected their livers from oxidative stress
Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats
In rats, the CB1 receptors in the hippocampus found to be involved in rewarding & aversion effects which has relevance to addiction
Activation of VTA/CeA/mPFC cannabinoid CB1 receptors induced conditioned drug effects via interacting with hippocampal CAMKII-CREB-BDNF signaling pathway in rats
In rats, the lateral hypothalamus (brain area involved with the body’s response to emotional stress) modulated their cardiovascular response to stress via the CB1 receptors & GABA
Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats
In a cellular culture mimicking the gut microbiome, probiotics engineered to produce butyrate downregulated the ECS
Engineered probiotics modulate the endocannabinoid system