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Research Roundup: Aug 1, 2022



Best of cannabinoid science this week...


In a survey of Parkinson’s patients, the use of cannabis was associated with improvements in motor function, sleep & pain Cannabis use in Parkinson’s disease—A nationwide online survey study https://onlinelibrary.wiley.com/doi/10.1111/ane.13602

Many patients with multiple sclerosis use cannabinoids for pain relief Cannabinoid use for pain relief among people with multiple sclerosis https://www.drugsandalcohol.ie/36550

A review of using cannabinoids for treating dementia Cannabinoids for the treatment of dementia: summary of a Cochrane review https://pubmed.ncbi.nlm.nih.gov/35778327

In a case study of a woman with severe recessive dystrophic epidermolysis bullosa (a rare genetic skin fragility disorder), after nothing else helped with the pain, oral CBD drops helped improve her pain to tolerable levels, improved her ability to swallow as well as her quality of life Purified oral cannabidiol for pain management in severe recessive dystrophic epidermolysis bullosa https://pubmed.ncbi.nlm.nih.gov/35593277

In rats with cuts in their skin, CBD improved inflammation & healing time, probably via the CB2 receptor Cannabidiol Improves Random-Pattern Skin Flap Survival in Rats: Involvement of Cannabinoid Type-2 Receptors https://pubmed.ncbi.nlm.nih.gov/35817049

In older rats, 7 days of CBD treatment caused an antidepressant effect Dose-Dependent Antidepressant-Like Effects of Cannabidiol in Aged Rats https://pubmed.ncbi.nlm.nih.gov/35847003

In mice being fed a high-fat diet, CBD & omega-3 fatty acids caused them to live longer & protected from brain damage Omega 3 Fatty Acid and Cannabidiol Prolong Lifespan and Ameliorates Brain Ischaemia in Mice Fed Chronic High Fat Diet https://www.scirp.org/journal/paperinformation.aspx?paperid=118370

In an older mouse model of Alzheimer’s, low doses of intranasal THC for 3 months significantly slowed memory decline The Memory Benefit to Aged APP/PS1 Mice from Long-Term Intranasal Treatment of Low-Dose THC https://pubmed.ncbi.nlm.nih.gov/35457070

In a mouse model of diabetes with heart problems, THC caused beneficial effects on insulin levels as well as improvements to the heart’s main blood vessel Vascular responses disrupted by fructose-induced hyperinsulinemia improved with delta-9-tetrahydrocannabinol https://internationalbiochemistry.com/jvi.aspx?un=IJMB-83703&volume=


A cool review of how oxytocin interacts with the endocannabinoids to alter social behavior Sex-specific and social experience-dependent oxytocin-endocannabinoid interactions in the nucleus accumbens: implications for social behaviour https://pubmed.ncbi.nlm.nih.gov/35858094


In rats, the ability of oxytocin to improve leaky guts through the vagus nerve seems to be mediated by endocannabinoid signaling Oxytocin acts centrally in the brain to improve leaky gut through the vagus nerve and a cannabinoid signaling in rats https://pubmed.ncbi.nlm.nih.gov/35839845


A review of using CBD for children with refractory epilepsy Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature https://pubmed.ncbi.nlm.nih.gov/35830160

A review of using CBD for chronic pain Efficacy, Safety, and Regulation of Cannabidiol on Chronic Pain: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/35860716

A review of GPCR18 – a receptor that may one day be known as CB3 or CB4 GPR18 receptor – the structure and the role in the physiology and pathophysiology https://pubmed.ncbi.nlm.nih.gov/35792647


A deep dive into how widespread the endocannabinoid system is in the roundworm family Pan-phylum In Silico Analyses of Nematode Endocannabinoid Signalling Systems Highlight Novel Opportunities for Parasite Drug Target Discovery https://pubmed.ncbi.nlm.nih.gov/35846343 This is a great look at how important the endocannabinoids are in even a more simple family like the nematodes. It speaks to how far back the ECS goes in evolutionary history. Even in this creature with 302 neurons (the C. elegans hermaphrodite), the endocannabinoids are necessary for homeostasis, brain growth & metabolism.