Best of cannabinoid science this week...
A case report of a chronic neuropathic pain patient who lessened her pregabalin use with a THC/CBD oil
Medication sparing after medical cannabis initiation: A case study of a chronic pain patient in Project Twenty21
A review of 11 studies on using PEA for chronic pain
Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials
A review on CBD's neuroprotective powers & its potential as a treatment for traumatic brain injuries Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries https://pubmed.ncbi.nlm.nih.gov/36816569/
A review on using the cannabinoids to treat inflammatory bowel disease
The Use of Cannabinoids in the Treatment of Inflammatory Bowel Disease (IBD): A Review of the Literature
How the gut microbiome plays a role in the cannabinoid’s ability to lower inflammation Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation https://pubmed.ncbi.nlm.nih.gov/36776218/ and a review of the gut microbiome-endocannabinoidome axis The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior https://pubmed.ncbi.nlm.nih.gov/36778747/
A review of 39 studies on how CBD moves through the human body Pharmacokinetics of Cannabidiol: A systematic review and meta-regression analysis https://pubmed.ncbi.nlm.nih.gov/36778355/
A review of the ability of CBD to alter genetic transcription
Cannabidiol goes nuclear: The role of PPARγ
In female rat sexual behavior, THC increased their proceptivity (a series of behaviors ranging from courting to copulation) The effects of delta-9-tetrahydrocannabinol administration in the regulation of female rat sociosexual behaviour https://pubmed.ncbi.nlm.nih.gov/36796802/
In a rat model of spinal cord injury, a combination of CBD & β-caryophyllene (one of the most common cannabis terpenes) reduced chronic pain Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model https://pubmed.ncbi.nlm.nih.gov/36913400/
In a mouse model of pain, PEA synergized with morphine & gabapentin to lower pain via the opioid receptors & the PPARα nuclear receptors (that regulate genetic transcription) N-palmitoylethanolamide synergizes the antinociception of morphine and gabapentin in the formalin test in mice https://pubmed.ncbi.nlm.nih.gov/36905375/
In mice addicted to cocaine, blocking the FAAH enzyme (an activity of CBD) reduced their addictive behaviors via the nucleus accumbens The FAAH inhibitor URB597 reduces cocaine seeking during conditioned punishment and withdrawal https://www.biorxiv.org/content/10.1101/2023.03.13.532386v1