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Research Roundup: Apr 30, 2024

Best of cannabinoid science this week...

In a range of tests on motor & cognitive performance, CBD cause no changes versus the placebo except for a small increase in the subjective ratings of sedation

Does acute cannabidiol (CBD) use impair performance? A meta-analysis and comparison with placebo and delta-9-tetrahydrocannabinol (THC)

In people with PTSD, cannabis-based medicines substantially reduced their symptoms after three months with greater improvements in those with comorbid depression than in those without

Medicinal cannabis for treating post-traumatic stress disorder and comorbid depression: real-world evidence

In an observational study of hospitalized patients with serious mental illnesses, the group will only use cannabis had less severity at admission & lower readmission rates

Retrospective examination of cannabis vs. other substance misuse: Associations with 30-day readmission and global assessment of functioning in hospitalized patients with serious mental illness

A thesis project interviewing college students with ADHD about the positives & negatives of cannabis use

“Higher” education : a mixed methods exploration of ADHD, cannabis use, and postsecondary academic success

In a cohort analysis of people who experienced traumatic injury, THC did not appear to be associated with increased risk of post-traumatic blood clots

Two-center analysis of cannabis on venous thromboembolism risk after traumatic injury: A matched analysis

In patients getting breast augmentation surgery, no significant differences if they were cannabis users

Peri-Operative Impact of Cannabis Use in Conjunction With Elective Primary Breast Augmentation in a Private Practice

A review of cannabinoids for mental illnesses by the great Dr. Müller-Vahl

Cannabinoids in the Treatment of Selected Mental Illnesses: Practical Approach and Overview of the Literature

“There is increasing evidence that cannabinoids may improve symptoms in autism spectrum disorder (ASD), Tourette syndrome (TS), anxiety disorders, and post-traumatic stress disorder (PTSD). According to surveys, patients often use cannabinoids to improve mood, sleep, and symptoms of attention deficit/hyperactivity disorder (ADHD).”

A book chapter on ALS & the therapeutic targets of the endocannabinoid system

The Endocannabinoid System as a Potential Therapeutic Target for Amyotrophic Lateral Sclerosis

“There is increasing evidence that cannabinoids, due to their anti-glutamatergic and anti-inflammatory actions, may show neuroprotective effects in ALS patients and slow the progression of the disease. Furthermore, cannabis-based medicine may be useful in managing symptoms like pain, spasticity or weight loss.”

A review of cannabinoids for dementia symptoms

Cannabinoids for Behavioral Symptoms in Dementia: An Overview

A review of using cannabis for post-COVID neuroinflammation (great charts!)

Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition

For inflammatory & autoimmune skin diseases, a review of 15 articles on the benefits of the cannabinoids, including for systemic sclerosis, dermatomyositis, psoriasis & atopic dermatitis (eczema)

Cannabinoids for the treatment of autoimmune and inflammatory skin diseases: A systematic review

A review of using cannabis in dentistry

Exploring the Therapeutic Potentials of Cannabis Sativa in Dentistry: A Scientific Review

On the many mechanisms of the neuroprotective effects of CBD

A novel insight into the neuroprotective effects of cannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions

“CBD showed protective effects against neuroinflammation via regulating AKT, CREB, BDNF expressions, NRF2 signaling, apelin and tyrosine hydroxylase synthesis.”

In a mouse model of traumatic brain injury, CBD improved their motor, memory & cognitive function by increasing brain blood flow as well as waste disposal via lymphatic drainage

In a mouse model of traumatic brain injury, CBD improved their motor, memory & cognitive function by increasing brain blood flow as well as waste disposal via lymphatic drainage

Cannabidiol Alleviates Neurological Deficits After Traumatic Brain Injury by Improving Intracranial Lymphatic Drainage

In a mouse model of Alzheimer's disease, a combination of THC & CBD restored the balance of glutamate (most common excitatory neurotransmitter) in the hippocampus (memory center of the brain)

A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer’s disease

In a mouse model of the dyskinesia from the Parkinson's treatment drug L-DOPA, a CBD derivative combined with a drug to activate the CB2 receptor (HU-910) decreased their dyskinesia & normalized their glutamate

4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms

In mice, a map of how CBD changes genes in the hippocampus (memory center of the brain) involved in synapse organization, chromosome modifications, formation of ribosomes (centers of protein synthesis) & function of the mitochondria (powerhouse of the cell)

Cannabidiol modulates hippocampal genes involved in mitochondrial function, ribosome biogenesis, synapse organization, and chromatin modifications

On new CBN based drugs for neurological disorders that inhibit the newly discovered cell death pathways of oxytosis/ferroptosis

Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders

On the effectiveness of CBD cream as an anti-inflammatory for the skin

Anti-inflammatory Evaluation of Cannabidiol from Cannabis sativa L. Obtained Using Supercritical Fluid Extraction and Cannabidiol Extract-Based Cream


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