Research Roundup: Apr 25, 2023

Best of cannabinoid science this week...

In a study of over 3500 people, they could find no way to predict the final medical doses of CBD & THC, recommending that “Clinical guidelines should maintain a highly individual approach for cannabinoid dosing” Can we predict the treatment doses of THC and CBD and does it matter? https://pubmed.ncbi.nlm.nih.gov/37003923/

In 20 elite athletes, topical CBD was well tolerated & helpful in a number of domains Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain https://pubmed.ncbi.nlm.nih.gov/36991501/

In a survey of women with muscular pelvic pain, the cannabis users found it effective for relieving the pain while non-cannabis users said they’d be willing to try it

Cannabis use preferences in women with myofascial pelvic pain: A cross-sectional study

https://www.sciencedirect.com/science/article/pii/S2590161323000170

In dogs stressed out by car travel or separation, one dose of CBD significantly lowered their stress-related measures A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel https://pubmed.ncbi.nlm.nih.gov/36908527/

A positive review on using CBD for eating disorders Major approaches to cannabidiol in the treatment of binge eating and obesity: a systematic review https://ijn.zotarellifilhoscientificworks.com/index.php/ijn/article/view/282

A strong series of case studies & research reports by neuropsychopharmacology world experts on using CBD for treating brain disorders Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II https://pubmed.ncbi.nlm.nih.gov/36909164/

In multiple sclerosis, a review of the evidence showing the combination of THC & CBD reduces spasticity

Use of cannabis medicine for the treatment of spasticity-associated pain

https://www.scielo.br/j/brjp/a/9syCLsBmLJF3g53GQvKMxXB/?lang=en

Plus this fMRI study of how this combination changes brain connectivity

Resting-state functional connectivity in multiple sclerosis patients receiving nabiximols for spasticity

https://pubmed.ncbi.nlm.nih.gov/36991352/

In mice exposed to the persistent organic pollutant perfluorooctane sulfonate, CBD protected the kidney cells from death via its antioxidant effects Perfluorooctane sulfonate-induced apoptosis in kidney cells by triggering the NOX4/ROS/JNK axis and antagonism of cannabidiol https://pubmed.ncbi.nlm.nih.gov/36988283/