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Research Roundup: Apr 18, 2023



Best of cannabinoid science this week...


In a study of 1000+ people, a month of CBD was associated with decreased daytime drowsiness & in older men, a lower prevalence of low testosterone levels

The Effects of Long-Term Self-Dosing of Cannabidiol on Drowsiness, Testosterone Levels, and Liver Function


In a clinical trial of people with Tourette syndrome or chronic tick disorders, nabiximols (1:1 THC:CBD sprays) did not help everyone, but seemed to work best in males with more severe ticks as well as with comorbid ADHD CANNA-TICS: Efficacy and safety of oral treatment with nabiximols in adults with chronic tic disorders - Results of a prospective, multicenter, randomized, double-blind, placebo controlled, phase IIIb superiority study https://pubmed.ncbi.nlm.nih.gov/36878177/


A clinical guide on cannabinoids & chronic pain management reviews 70 studies

Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions


A review of using CBD & CBDA in veterinary medicine

The clinical use of cannabidiol and cannabidiolic acid-rich hemp in veterinary medicine and lessons from human medicine


A review of studies on treating stimulant use disorder by targeting the endocannabinoid system Endocannabinoid system as a therapeutic target for psychostimulants relapse: A systematic review of preclinical studies https://pubmed.ncbi.nlm.nih.gov/36965745/


A study of CBD's anti diabetic & antioxidant effects Computational insights into the antioxidant and antidiabetic mechanisms of cannabidiol: An in vitro and in silico study https://www.sciencedirect.com/science/article/pii/S1878535223003040


In a rat model of maternal obesity, CBD improved their metabolic profile & decreased inflammation in the hypothalamus (a regulator of homeostasis, appetite & hormonal release) Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity https://pubmed.ncbi.nlm.nih.gov/36969815/


In a rat model of kidney disease, CBD lowered inflammatory signals Cannabidiol interacts with the FXR/Nrf2 pathway and changes the CB1/CB2 receptors ratio in gentamicin-induced kidney injury in rats https://pubmed.ncbi.nlm.nih.gov/36865046/


In a rat model of an inflamed prostate, CBC, CBG & CBD all improved cellular inflammation while CBD also reduced pelvic pain via their anti-inflammatory effects CANNABINOIDS REDUCE CHRONIC PROSTATITIS AND CHRONIC PELVIC PAIN SYNDROME BY MODULATING TLR-4/NF-KB SIGNALING PATHWAY https://www.auajournals.org/doi/abs/10.1097/JU.0000000000003235.08


In a roundworm model of Parkinson's disease, CBD rescued damage to the dopamine producing neurons Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans https://pubmed.ncbi.nlm.nih.gov/36964823/


A look at how CBD & CBDA move through the body & get broken down in humans & domestic animals A One Health perspective on comparative cannabidiol and cannabidiolic acid pharmacokinetics and biotransformation in humans and domestic animals https://pubmed.ncbi.nlm.nih.gov/36972696/

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