Research Roundup: Sept 2, 2025
- Lex Pelger
- Sep 2
- 3 min read
Best of cannabinoid science this week...
For blood pressure, this meta-analysis found that acute CBD reduced systolic blood pressure & chronic CBD reduced both systolic & diastolic blood pressure
Systematic Review and Meta-analysis to Investigate the Effects of Cannabidiol on Blood Pressure: Examination of Randomized Triple- and Double-Blind Placebo Trials
For people with treatment-resistant diabetic neuropathy (painful dysregulated nerve signals), long-term inhaled cannabis therapy was associated with significant reductions to pain severity, pain interference in their lives, neuropathic symptom scores & opioid usage as well as improved glycemic control
Long-Term Efficacy and Safety of Inhaled Cannabis Therapy for Painful Diabetic Neuropathy: A 5-Year Longitudinal Observational Study
In people with fibromyalgia, 6 months of Bedrocan cannabis reduced their severity scores, especially epigastric pain, abdominal pain, stomach burning & bloating
The effect of medical cannabis on gastrointestinal symptoms in fibromyalgia and disorders of gut-brain interaction: a patient-centred real-world observational study
In people with pancreatitis, cannabis use was associated with decreased odds of ICU admission, embolisms, pancreatic cancer & mortality
Cannabis Use and Outcomes in Patients with Chronic Pancreatitis: A National Inpatient Sample Analysis
In people with spinal cord injuries, one month of Sativex (1:1 THC:CBD spray) improved spasticity
The effects of nabiximols (Sativex®) on spasticity and non-motor symptoms in chronic spinal cord injury (SCI): a longitudinal prospective study
In people with insomnia, a meta-analysis of 6 trials with 1k+ patients found cannabinoids significantly improved sleep quality, especially non-CBD formulations
Effectiveness of Cannabinoids for Improving Sleep Quality in People with and without Insomnia or Poor Sleep: A Systematic Review and Meta-Analysis of Randomised Studies
In people with treatment-resistant focal epilepsies, CBD reduced focal seizures & total seizures
Long-term efficacy and safety of cannabidiol in patients with treatment-resistant focal epilepsies treated in the Expanded Access Program
For dermatology, a meta-analysis of 11 trials with 3,300+ participants found cannabinoids helped with itchiness, atopic dermatitis (eczema) & transepidermal water loss
Cannabis and cannabinoids in dermatology: A systematic review and metaanalysis of quantitative outcomes
A review on the sex-specific effects of cannabis (with a good chart)
Sex-Specific Responses to Cannabis Exposure: Implications for Behavior and Beyond
In epilepsy, a review of endocannabinoid signaling (nice charts)
Endocannabinoid signaling in epilepsy
For dermatology, a review of the cannabinoids for atopic dermatitis (eczema), psoriasis & acne
Therapeutic potential of Cannabis sativa L. in dermatological applications
For eye diseases, a review of the potential of targeting the endocannabinoid system
The Endocannabinoid System: Role in Ocular Physiology and Therapeutic Potential in Eye Diseases: A Narrative Review
For canine epilepsy, a review of using CBD [Spanish]
Uso del cbd como terapia adyuvante en la epilepsia canina: revisión bibliográfica de los estudios
In rat brain blood flow, THC increased functional connectivity & cerebral blood flow while CBD decreased functional connectivity without altering cerebral blood flow, with the combination of THC & CBD causing moderate increases to both functional connectivity & cerebral blood flow
Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study
In a mouse model of ulcerative colitis, oral CBD/CBG hemp extract reduced pain & damage
Orally Administered CBD/CBG Hemp Extract Reduces Severity of Ulcerative Colitis and Pain in a Murine Model
In a mouse model of ulcerative colitis, hemp seed oil alleviated symptoms, repaired damage to the intestinal barrier & restored gut microbiota dysbiosis
Hemp seed oil ameliorates ulcerative colitis in connection with tryptophan metabolism driven by gut microbiota
In the mouse olfactory circuit for smell, the terpene beta-caryophyllene improved anosmia (loss of smell), reduced information & lowered cell death via the renin-angiotensin system
β-Caryophyllene's potential modulation of the renin-angiotensin system: Implications for anosmia and neuroinflammation in the olfactory circuitry
In a tissue model of atopic dermatitis (eczema), cannabis extracts suppressed genes related to inflammation while upregulating skin moisturizing factors in keratinocytes (skin stem cells)
Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells
Against MRSA, the cannabinoids CBD, THC, CBN, CBG, & CBC demonstrated anti-biofilm activity, with CBN being the strongest & and CBD being the weakest, yet the CBD caused the greatest membrane damage
The anti-biofilm activity of cannabinoids against methicillin-resistant Staphylococcus aureus
Comments