Research Roundup: Sept 16, 2025
- Lex Pelger
- Sep 16
- 3 min read
Best of cannabinoid science this week...
In people with chronic pain, a full-spectrum cannabis extract decreased pain, anxiety & insomnia with a ~third of the subjects reducing or discontinuing other painkillers and/or anti-inflammatory drugs
Effectiveness of Full Spectrum Cannabis Extracts in the Treatment of Chronic Pain: An Open Label Study
In people with spinal cord injuries, a survey found that they used cannabis for alleviating pain & improving sleep, with edibles being the most common modality
Understanding Cannabis Use After Spinal Cord Injury: A Canadian Survey Study
For people with pain from endometriosis, a survey found that their preferred ingestion methods were smoking & oils, with evidence for inhalation being the most effective
“A dose of relief?”: Results of an international survey exploring self-reported effectiveness, dose and dosage forms of cannabis for endometriosis pain and related symptoms
In underrepresented groups experiencing discrimination, CBD was helpful in reducing negative emotional symptoms in the short term without increasing risk for disordered alcohol use
Effects of Cannabinoids on Emotional States and Alcohol Use Among Underrepresented Groups: Moderation by Perceived Discrimination
In people undergoing total knee replacement, those who received 400 milligrams of CBD had lower opioid requirements & pain scores while 800 mg caused more CBD side effects
OP60 Effects of cannabidiol (CBD) oral solution in patients undergoing bilateral total knee arthroplasty: a randomized, controlled, parallel, triple blind, pilot study
In female university students, six weeks of PEA enhanced physiological resilience to stress as indicated by improved heart rate variability
The effects of formulated palmitoylethanolamide supplementation on indicators of stress and heart rate variability in female university students: a randomised crossover trial
A case report of a young girl with Lennox-Gastaut Syndrome (a severe childhood epilepsy) helped greatly by a 20:1 CBD:THC formula
Management of Lennox-Gastaut Syndrome with a CBD/THC Isolate Combination
A review of the potential of cannabis for global health (nice charts)
From farm to bedside: Potential of medical cannabis in global health
In sickle cell disease, a review of 12 papers on cannabinoids
Cannabis Use for Chronic Pain in Sickle Cell Disease: A Scoping Review
For orofacial pain, a review of 10 CBD studies found it caused painkilling, anti-inflammatory & muscle-relaxant effects as well as helping with bruxism (teeth grinding) when applied topically
Cannabidiol for Orofacial and Upper-Quarter Pain: A Systematic Evaluation of Therapeutic Potential
For wound healing, a review of the evidence for cannabis
Role of Cannabis sativa on wound healing: An update
For chronic pain, a review on the clinical effects & legal barriers of cannabinoids (nice charts)
Cannabinoids in Chronic Pain: Clinical Outcomes, Adverse Effects and Legal Challenges
And for lower back pain, a thesis project on the involvement of the endocannabinoid system
An investigation of the endocannabinoid system in low back pain
In female rats with a high-fat diet & unpredictable chronic mild stress, CBD promoted coping behavior, increased locomotion, reduced freezing & less depressive-like behavior as well as changes to neuroinflammatory factors
Cannabidiol Effects on Depressive-like Behavior and Neuroinflammation in Female Rats Exposed to High-Fat Diet and Unpredictable Chronic Mild Stress
In a rat model of chronic unpredictable stress, inhibiting the FAAH enzyme (which breaks down anandamide) protected them from the loss of dopamine levels
The effects of FAAH inhibitor, URB597, on dopamine content, synthesis and degradation in the striatum of the rats exposed to chronic unpredictable stress
In a rat model of Alzheimer's disease & neuropathic pain, a cannabis extract improved their mechanical & thermal sensitivity as well as cognitive functions
EP062 Therapeutic potential of an EU-GMP certified cannabis sativa L. in neuropathic pain concurrent with alzheimer’s disease: preclinical insights
In a mouse model of Alzheimer's, CBD improved their short-term memory, reduced alpha-beta plaque accumulation, lessened oxidative damage & decreased activation of the microglia (guardian immune cells of the brain)
Cannabidiol improves short-term memory in a Streptozotocin-induced animal model of Alzheimer’s disease
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