Research Roundup: Oct 7, 2025
- Lex Pelger
- Oct 7
- 3 min read
Best of cannabinoid science this week...
For chronic lower back pain, VER-01 (a proprietary cannabis extract) reduced pain over the 12 weeks of this double-blind trial
Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial
For people with a substance use disorder, the UK Medical Cannabis Registry found cannabis use associated with a reduction in prescribed opioids & an improvement in health-related quality of life
UK Medical Cannabis Registry: A Clinical Analysis of Patients with Substance Use Disorder
In two siblings with Lafora disease (rare inherited form of progressive epilepsy), CBD improved their seizures & cognitive symptoms
Use of cannabidiol in the management of refractory seizures in lafora disease: A case report of two siblings
For cannabis helping with recovery from psychosis, a personal account by a healthcare practitioner [Dutch]
Hersteld of niet hersteld? Hoe cannabis mijn herstel van psychose bevorderd heft [Recovered or Not Recovered? How Cannabis Aided My Recovery from Psychosis]
For dermatology & cosmetic skin health, a review of the efficacy of CBD for acne, psoriasis, atopic & seborrheic dermatitis (chronic inflammatory skin conditions), allergic contact dermatitis, pruritus (itchiness), wound healing, hair disorders, skin cancers & pigmentation disorders as well as help skin rejuvenation, collagen & hydration (nice charts)
Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science
For cancer-related symptoms, this review of 98 articles found cannabinoids helped appetite & reduced pain, anxiety, insomnia & chemotherapy-induced nausea & vomiting
Indications of Cannabinoids for the Palliation of Cancer-Associated Symptoms: A Systematic Review and Meta-Analysis
For epilepsy, a review of the targets of the cannabinoids (great charts)
Molecular targets of cannabinoids and their derivatives in epilepsy – a review with focus on CBD
For nitric oxide (the gaseous neurotransmitter), a review of CBD's help for inflammation & oxidative stress via effects on nitric oxide levels & nitric oxide synthase (with nice charts!)
The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease
For autism, a review of 11 studies on the potential of cannabinoids
Therapeutic Use of Cannabis Derivatives and Their Analogs for Autism Spectrum Disorder: A Systematic Review
In two mouse models of acute pain, CBD reduced pain behaviors during both the neurogenic & inflammatory phases
Cannabidiol alleviates pain and inflammation: insights from acute pain models
In a rat model of inflammatory pain, THC worked better than CBD or the combination of THC & CBD, with females more sensitive to THC's painkilling effects
Cannabidiol interactions with Δ-9-tetrahydrocannabinol on antinociception after carrageenan-induced inflammatory pain in male and female rats
In a mouse model of Alzheimer's disease, CBD alleviated synaptic & cognitive deficits via reduced alpha-beta plaque accumulation, neuroinflammation, & insulin resistance with a novel CBD target of the TrkB adaptor protein
Mechanistic Insights into Cannabidiol-Mediated TrkB Activation via FRS2 Interaction in Attenuating Alzheimer's Disease Pathology and Cognitive Impairment
In a rat model of depression, CBD demonstrated “potent antidepressant-like effects” via enhanced dendritic spine density & synaptic strength in the hippocampus (memory center of the brain)
Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress
In a rat model of fear, CBD lessened anxiety-like behaviors & neuropathic pain scores via BDNF (a key brain growth factor) in the hippocampus (memory center of the brain)
Chronic Cannabidiol Treatment Effects on Contextual Fear and Neuropathic Pain in Carioca Rats High and Low Conditioned Freezing
In a mouse model of rosacea (a chronic inflammatory skin disorder of facial redness, flushing & pustules), CBD lowered inflammation, redness, skin thickness & mast cell infiltration while combining well with the common treatment of metronidazole
Cannabidiol as a therapeutic agent for rosacea through simultaneous inhibition of multiple inflammatory pathways
In a fruit fly model of Alzheimer's disease, CBD lowered their motor & cognitive deficits & reduced neuropathological changes
Cannabidiol-mediated neuroprotection in amyloid beta-induced Alzheimer’s model of drosophila: behavioral and morphological evidence
In a mouse model of osteoarthritis, the terpene beta-caryophyllene reduced cartilage tissue injury, inflammatory cell infiltration & measures of oxidative stress
Effect and mechanism of beta-caryophyllene in mice with osteoarthritis
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