Research Roundup: Oct 21, 2025
- Lex Pelger
- 13 minutes ago
- 2 min read
Best of cannabinoid science this week...
For CBD in developmental & epileptic encephalopathies (rare & severe treatment-resistant childhood epilepsies), a meta-analysis of 13 studies found reduced seizure frequency, with 20% having a 50+% reduction
Efficacy and safety of cannabidiol in children with developmental and epileptic encephalopathies: A systematic review
In children with autism & their families, medical cannabis was linked to less parental distress & positive changes in family routines, enhanced well-being & improved parental engagement in meaningful activities & social interactions
Effects of Medical Cannabis Treatment for Autistic Children on Family Accommodation: An Open-Label Mixed-Methods Study
In people with ADHD, chronic cannabis users self-reported less sluggish cognitive tempo, impulsivity, irritability, and anxiety than non-users & on objective tests, they had worse cognition on 2 cognition tests but better impulse control on 2 tests
A naturalistic examination of the effects of chronic and acute cannabis use on cognition and perceived symptoms of attention-deficit/hyperactivity disorder
For medication substitution, a survey of people in Los Angeles found 60% reported using cannabis to replace medications (sedatives/sleep aids, anxiolytics, opioids & antidepressants)
Cannabis as a substitute for prescription drugs: A cross-sectional study of primary care patients in Los Angeles
In Germany, on why people use CBD (as always, the list was sleep, pain, depression & anxiety)
Beyond the hype - who uses cannabidiol for self-medication – and why: a cross-sectional study in Germany
In a case report of myofascial temporomandibular disorder (facial & jaw pain), a 1:1 THC:CBD oil improved pain and percent sleep quality
Full Spectrum Cannabis Oil for the treatment of chronic pain and sleep dysfunction in myofascial temporomandibular disorder: a case report
For a young person with Dravet syndrome, low-dose whole-plant extract lessened seizures & after 4 years, led to the discontinuation of all pharmaceuticals
Whole Plant Cannabinoid Nonpharmaceutical Treatment Protocols for a Young Male With Dravet Syndrome
In healthy adults, high-fat meals increased CBD absorption compared to high-carb meals
A prior high-fat meal increases plasma cannabidiol concentrations compared to an isoenergetic high-carbohydrate meal in healthy young participants: a randomised crossover study
For visual function & optical quality, CBD did not alter static & dynamic visual acuity, motion detection, optical quality, stereoacuity or pupil size
Influence of Cannabidiol Use on Visual Function and Optical Quality: A Randomized Controlled Trial
In a metabolic analysis of male cannabis users, 92 metabolites had decreased or increased levels compared to nonusers
Metabolic Profile of Male Cannabis Users and Estimation of Candidate Biomarkers
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