Research Roundup: Apr 7, 2026
- 7 days ago
- 3 min read
Best of cannabinoid science this week...
In people with exercise-induced muscle injury, CBD caused less peak pain at rest & with movement as well as less strength impairment & physical disability
Efficacy and safety of cannabidiol (CBD) on reducing pain and functional impairment associated with exercise-induced muscle injury: a randomized placebo-controlled feasibility trial
In people with kidney failure, interviews on the improvements from CBD
WCN26-3667 PATIENT EXPERIENCES WITH CANNABIDIOL FOR SYMPTOM MANAGEMENT IN KIDNEY FAILURE: QUALITATIVE INSIGHTS FROM THE SEISMIC-CBD TRIAL
And on the pharmacokinetics of CBD moving through their system
WCN26-5407 PHARMACOKINETICS OF CANNABIDIOL IN PEOPLE WITH KIDNEY FAILURE: FINDINGS FROM THE SEISMIC-CBD TRIAL
In people experiencing dizziness, a survey found the majority willing to consider cannabis & 20% reported cannabis to cause a moderate to large subjective relief
A Cross-Sectional Survey of Cannabis Use and Utility Among Patients Experiencing Dizziness
In children with 22q11.2 deletion syndrome (a genetic disease of developmental delays & a range of potential effects), a topical CBD gel caused improvements on all measures, including disease severity, anxiety, behavior & caregiver reported effects
Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031)
In people with chronic neuropathic pain, capsules of 1:1 THC:CBD caused substantial pain reductions & improved health-related quality of life in physical & social functioning, energy/fatigue & emotional well-being
Analgesic and Quality of Life Effects of 1:1 Delta-9-Tetrahydrocannabinol: Cannabidiol Oral Formulation on Chronic Neuropathic Pain Subjects During a Four-Week Observation Period: Pilot Study
In people with anorexia nervosa, CBD was well tolerated & caused small increases in body mass index
Cannabidiol in Anorexia Nervosa: A Double-Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change
In a case report of someone with geographic tongue (inflammatory patches of missing papillae on the tongue), full-spectrum CBD oil caused significant improvements to oral pain
Full Spectrum Cannabidiol Oil as a Symptomatic Management Strategy in Geographic Tongue: Case Report with Literature Review
When giving CBD to fed or fasting dogs, an analysis of their fecal excretions found better bioavailability when fed
Comparative plasma exposure and fecal excretion of oral cannabidiol in fasted and fed dogs: pilot study
On CBD for developmental epilepsy, a review of the mechanisms (with nice charts)
Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows
In a mouse model of Parkinson’s disease, both CBD & THC individually & in combination caused antidepressant-like effects & significantly elevated brain dopamine levels
Antidepressant-like Effects of Cannabidiol and Tetrahydrocannabinol in a Reserpine-induced Mouse Model of Parkinson’s Disease
In a mouse model of acute lung injury, CBD reduced inflammation & suppressed the immune system response of neutrophils & macrophages
Cannabidiol hinders lipopolysaccharide-induced neutrophils migration to the lungs through suppressing nuclear factor kappa-B signal and expression of interleukin-1 beta in macrophages
In a rat model of neuropathic pain & a tolerance to opioids, CBD reduced their mechanical hypersensitivity & partially counteracted the metabolic dysregulation
Cannabidiol (CBD) modulates the serotonin–kynurenine metabolic balance in the brain of morphine-tolerant neuropathic rats
In a rat model of phantom limb pain, given prophylactically, either THC or CBD+ beta caryophyllene reduced onset & severity, while with delayed treatment, the most effective were CBD+THC+ beta caryophyllene or CBD+ beta caryophyllene, working via GABA (the brain’s most common inhibitory neurotransmitter) in the spinal cord
Targeting Phantom Limb Pain with Cannabinoids in a Rat Model
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