Best of cannabinoid science this week...
In states with medical cannabis laws, they experienced a significant decrease in employee health insurance cost
Measuring the Impact of Medical Cannabis Law Adoption on Employer-Sponsored Health Insurance Costs: A Difference-in-Difference Analysis, 2003-2022
In people with anxiety in the UK Medical Cannabis Registry, cannabis-based medicines were associated with improvements in anxiety, sleep & quality of life over 12 months with no differences between the formulations used
UK Medical Cannabis Registry: a cohort study of patients prescribed cannabis-based oils and dried flower for generalised anxiety disorder
For endometriosis, a review of surveys on the benefits of CBD
Endometriosis: cannabidiol therapy for symptom relief
In people & in a tissue model of atopic dermatitis (eczema), a CBD cream reduced itch via modulation of the immune system
Cannabidiol modulation of immune cell function: in vitro insights and therapeutic implications for atopic dermatitis
In healthy adults, two weeks of broad-spectrum CBD use did not lead to a positive urine test & was associated with a significant reduction in sleep disturbances & pain intensity
Urinalysis and Perceived Effects Following 2-Week Use of a Commercial Broad-Spectrum Cannabidiol Product
In public health data of 5k+ Danish men, the cannabis users had less cognitive decline from early adulthood to late midlife
Cannabis Use and Age‐Related Changes in Cognitive Function From Early Adulthood to Late Midlife in 5162 Danish Men
In males exercising on a treadmill, CBD did not alter their thermoregulation but did cause minor immunosuppressive effects
Effects of Cannabidiol Ingestion on Thermoregulatory and Inflammatory Responses to Treadmill Exercise in the Heat in Recreationally Active Males
In people with neuropathic pain from diabetes, a transdermal patch of THC, CBD & CBN applied to their lower extremities significantly reduced pain scores with an excellent safety profile
Efficacy and safety of transdermal medical cannabis (THC:CBD: CBN formula) to treat painful diabetic peripheral neuropathy of the lower extremities
In people with rare childhood epilepsies, CBD reduced both focal & generalized seizures with over 50% seizure reduction in over two-thirds of the participants
Adjunctive cannabidiol offer long term efficacy for adult patients with Dravet’s and Lennox-Gastaut Syndromes’
And in people with drug-resistant epilepsy, a retrospective study of pharmaceutical CBD treatment found it may benefit all adult patients, particularly those already receiving clobazam
Cannabidiol Treatment for Adult Patients with Drug-Resistant Epilepsies: A Real-World Study in a Tertiary Center
In a case report of somebody with spondyloarthritis (a chronic inflammatory disease of the spinal column), CBD helped control their pain
Cannabidiol for the Treatment of Cervical Spondyloarthritis-Related Pain: A Case Report
A review’s review: an analysis of 23 systematic reviews on medical cannabis
Evidence synthesis of medical cannabis research: current challenges and opportunities
For pain, a review of using CBD & how it alters the epigenetics of the opioid & cannabinoid receptors
Opioid and Cannabinoid Systems in Pain: Emerging Molecular Mechanisms and Use in Clinical Practice, Health, and Fitness
For exercise & recovery, a review of seven articles that support CBD's benefit for strength parameters, power, oxygenation & recovery
The Effect of Cannabidiol on Performance and Post-Load Recovery among Healthy and Physically Active Individuals: A Systematic Review
For rheumatic diseases, a review of using cannabinoids to target the endocannabinoid system for pain, inflammation & joint metabolism (one good chart!)
Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases
In kidney damage from diabetes, a review of PEA’s protective & therapeutic effects
Protective and Therapeutic Efficacy of Palmitoylethanolamide in Diabetes Induced Renal Damage: A Narrative Review of Scientific Evidences
For ADHD, a review of using cannabis
Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review
For psychiatric disorders, a review of 23 studies on the minor cannabinoids
Therapeutic potential of minor cannabinoids in psychiatric disorders: A systematic review
In a rat model of sleep, CBN increased total sleep time as well as non-rapid eye movement (NREM) & rapid eye movement (REM) sleep, with its metabolite showing surprisingly high activity at brain CB1 receptors
A sleepy cannabis constituent: cannabinol and its active metabolite influence sleep architecture in rats
In a mouse model of Alzheimer's disease, the combination of THC & CBD (but not when either of them was alone) reduced extracellular glutamate levels & the excitability of the hippocampus, suggesting their utility against the excitotoxicity of the condition
A combination of Δ9 -tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease
In a mouse model of obesity, the endocannabinoid oleoylethanolamide (anti-hunger neurotransmitter) protected their hearts from lipid dysmetabolism & decreased cardiac inflammation & fibrosis (scarring) via the PPAR nuclear receptors (regulators of genetic transcription)
Oleoylethanolamide mitigates cardiometabolic disruption secondary to obesity induced by high-fat diet in mice
In a rat model of methamphetamine use disorder, CBD modulated the addictive properties via a dopamine receptor
Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors
In a mouse model of apnea due to opioids, CBD pretreatment antagonized this fatal opioid response
Proof of Concept for High-Dose Cannabidiol Pretreatment to Antagonize Opioid Induced Persistent Apnea
In a mouse model of anxiety, the terpenes linalool & β‐myrcene had gendered responses in their combination with CBD
Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β‐Myrcene, in Mice
In a tissue model of the neuroinflammation of autism, a low-THC extract reduced inflammatory markers & protected neuronal proliferation & differentiation under conditions of excitotoxicity (the brain harming itself from overfiring)
Evaluation of the Efficacy of a Full-Spectrum Low-THC Cannabis Plant Extract Using In Vitro Models of Inflammation and Excitotoxicity
Against the COVID-19 virus, cannabis extracts & their secondary metabolites reduced activity, especially CBD & THC,
Secondary metabolite profiles and anti-SARS-CoV-2 activity of ethanolic extracts from nine genotypes of Cannabis sativa L.
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