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Research Roundup: May 9, 2023



Best of cannabinoid science this week...


On how CBD binds to 56 different molecular targets in the brain The Polypharmacological Effects of Cannabidiol https://pubmed.ncbi.nlm.nih.gov/37050032/


For the spasticity of multiple sclerosis, a review of five studies supports the use of THC/CBD sprays as an effective add-on treatment Effectiveness and Safety of Cannabinoids as an Add-On Therapy in the Treatment of Resistant Spasticity in Multiple Sclerosis: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/37057959/


A review of eight studies on the benefits of using cannabinoids for facial pain Cannabis and cannabinoid medications for the treatment of chronic orofacial pain: A scoping review https://odontologos.com.co/assets/doc/news/2023-04-09_2359341-s2.0-S2772559623000019-main.pdf And a review of PEA for facial pain Orofacial Pain Management: An Overview of the Potential Benefits of Palmitoylethanolamide and Other Natural Agents https://pubmed.ncbi.nlm.nih.gov/37111679/


In a review of public health data from the UK, cannabinoid based medicines improved the outcomes for chronic pain patients Clinical outcome data of chronic pain patients treated with cannabis-based oils and dried flower from the UK Medical Cannabis Registry https://pubmed.ncbi.nlm.nih.gov/37021592/


In a monkey model of HIV, the typical intestinal barrier dysfunction can be reduced by low doses of THC Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection https://pubmed.ncbi.nlm.nih.gov/37036007/


In mice with neuropathic pain, injection of CBD lowers the pain via serotonin & TRPV1 receptors Peripherally injected canabidiol reduces neuropathic pain in mice: Role of the 5-HT1A and TRPV1 receptors https://pubmed.ncbi.nlm.nih.gov/37068389/ And in another model in rats, help with the pain as well as with the depressive behaviors & memory impairment via changes in the hippocampus Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: role of prelimbic neocortex hippocampal connections https://assets.researchsquare.com/files/rs-2781595/v1/c3013d5e-f965-4def-9b30-1e0708aad747.pdf?c=1680789984


A mouse model of Alzheimer's disease, CBDA & THCA rescued memory deficits & reduced the damage by the Aβ plaques & tau proteins The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer's Disease-like Mouse Model https://pubmed.ncbi.nlm.nih.gov/37047798/


In a rat model of osteoarthritis, CBD inhibited inflammation, lowers pain & reduces pathological changes Cannabidiol inhibits inflammation in rat osteoarthritis https://europepmc.org/article/ppr/ppr641884


In heart cells, CBD inhibited the transition from endothelial to mesenchymal state linked to heart fibrosis (scarring) & heart failure (it might even reverse the transition) Cannabidiol Not Only Inhibits Endothelial-to-mesenchymal Transition But Also Promotes The Reverse Process Of Mesenchymal-to-endothelial Transition In An In Vitro Model https://www.sciencedirect.com/science/article/abs/pii/S1071916422007874


In mice with colon cancer, full spectrum hemp extracts increase their survival and reduce their cachexia (wasting syndrome of muscle mass loss) Liposomal hemp extract for the management of cachexia https://ffhdj.com/index.php/BioactiveCompounds/article/viewFile/1007/1813


In fat tissue, THCV protected the stem cells against inflammation & stress of the endoplasmic reticulum (a protein production & folding center of the cell) Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis https://pubmed.ncbi.nlm.nih.gov/37108282/

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