Best of cannabinoid science this week...
In people with chronic pain, a survey of CBD users found it associated with decreased pain- even at low dosages (<100 mg)
A Survey on the Use of Cannabidiol (CBD) Isolate, Its Perceived Benefits, and Associated Side Effects Among Subjects With Chronic Pain
In chronic pain patients, a shortage of dronabinol (synthetic THC) significantly increased their pain intensity, disrupted their sleep & raised the level of pain interference with their daily lives
[Impact of dronabinol shortage on a population of chronic pain patients: A retrospective observational study]
“The number of patients with permanent pain increased 5-fold (n=2 at M0 and n=10 at M3). The number of patients with more than 20 painful attacks per 24 hours increased 2-fold”.
In people with frontotemporal dementia, the combination of PEA & luteoline showed less cognitive & functional decline
Phase 2 study of palmitoylethanolamide combined with luteoline in frontotemporal dementia patients
For Lennox-Gastaut syndrome (a severe childhood epilepsy), a cost-effectiveness analysis found CBD be cost-effective compared with usual care
Value of cannabidiol as adjunctive treatment for Lennox Gastaut syndrome: cost-effectiveness and budget impact analysis
In humans, the pharmacokinetics of full-spectrum hemp products with a focus on CBD, CBDA, THC & THCA
The Pharmacokinetics and Pharmacodynamics of a Hemp-Derived “Full-Spectrum” Oral Cannabinoid Product with a 1:1 Ratio of Cannabidiol to Cannabidiolic Acid and Delta-9-Tetrahydrocannabinol to Delta-9-Tetrahydrocannabinolic Acid
In a mouse model of dermatitis (inflamed & itchy skin), a cannabis topical lessened inflammation & levels of mast cells (immune cells carrying histamine)
Anti-Inflammatory Activity of Cannabis sativa L. Extract in 2,4-Dinitrochlorobenzene-Induced Dermatitis in Rats
In the hearts of diabetic rats, THC improved cardiac function & reduced markers of cardiomyopathy (heart muscle disease) via the SIRT3/FOXO1 mitochondrial & TLR4/NF-κB/NLRP3 pathways
Involvement of SIRT3/FOXO1 and TLR4/NF-κB/NLRP3 pathways in protective effects of Δ(9)-tetrahydrocannabinol on diabetic cardiomyopathy in rats
In a rat model of pregnancy inflammation & preterm labor, CBD decreased inflammation levels & oxidative stress parameters
Investigation of the Protective Effects of Cannabidiol on Rat Maternal and Fetal Brain Tissues in Lipopolysaccharide-induced Pregnancy Inflammation Model
Molecular analysis on how the cannabinoids act as antioxidants
Kinetic studies of the rich interaction of cannabinoids with oxygen-centered radicals and excited carbonyl compounds
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