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Research Roundup: Mar 28, 2023

Best of cannabinoid science this week...

In patients at a high risk of psychosis, CBD helped to normalize the levels of glutamate in their hippocampus, suggesting a protective effect Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk

In a monkey model of HIV, long-term low-dose THC reduced neuroinflammation, enhanced endocannabinoid levels & helped the gut brain axis via the promotion of neuroprotective gut bacteria Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels

In a fish model of motor dysfunction from haloperidol (a drug commonly used to treat Parkinson's), CBD almost completely reversed the motor dysfunction via dopamine receptors Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug

In a model of cystitis & bladder pain (a disease of chronic inflammation of the urinary bladder), CBD reduced inflammation & oxidative stress Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress

In a rat model of obesity, two weeks of CBD reduce the intramuscular fatty acid, lowered the production of new lipids in the muscles & profoundly improved the ratios of the lipids Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis

In dental stem cells, CBD improved their ability to create new bone cells Dental pulp stem cells-derived cannabidiolpretreated micro-spheroids showed robust osteogenic potential via upregulation of WNT6

In an atomic study of Alzheimer’s Aβ plaques, CBD helped to sequester them & potentially reduce neurotoxicity Cannabidiol-Mediated Sequestration of Alzheimer’s Amyloid-β Peptides in ADDL Oligomers


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