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Research Roundup: Mar 28, 2023



Best of cannabinoid science this week...


In patients at a high risk of psychosis, CBD helped to normalize the levels of glutamate in their hippocampus, suggesting a protective effect Hippocampal Glutamate, Resting Perfusion and the Effects of Cannabidiol in Psychosis Risk https://www.medrxiv.org/content/medrxiv/early/2023/03/05/2023.03.02.23286709.full.pdf


In a monkey model of HIV, long-term low-dose THC reduced neuroinflammation, enhanced endocannabinoid levels & helped the gut brain axis via the promotion of neuroprotective gut bacteria Cannabinoids modulate the microbiota-gut-brain axis in HIV/SIV infection by reducing neuroinflammation and dysbiosis while concurrently elevating endocannabinoid and indole-3-propionate levels https://pubmed.ncbi.nlm.nih.gov/36890518/


In a fish model of motor dysfunction from haloperidol (a drug commonly used to treat Parkinson's), CBD almost completely reversed the motor dysfunction via dopamine receptors Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug https://pubmed.ncbi.nlm.nih.gov/36871008/


In a model of cystitis & bladder pain (a disease of chronic inflammation of the urinary bladder), CBD reduced inflammation & oxidative stress Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress https://pubmed.ncbi.nlm.nih.gov/36902479/


In a rat model of obesity, two weeks of CBD reduce the intramuscular fatty acid, lowered the production of new lipids in the muscles & profoundly improved the ratios of the lipids Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis https://pubmed.ncbi.nlm.nih.gov/36879113/


In dental stem cells, CBD improved their ability to create new bone cells Dental pulp stem cells-derived cannabidiolpretreated micro-spheroids showed robust osteogenic potential via upregulation of WNT6 https://assets.researchsquare.com/files/rs-2580851/v1/fe75f386-c2bf-447b-8b26-576ee7800691.pdf?c=1677701720


In an atomic study of Alzheimer’s Aβ plaques, CBD helped to sequester them & potentially reduce neurotoxicity Cannabidiol-Mediated Sequestration of Alzheimer’s Amyloid-β Peptides in ADDL Oligomers https://www.scirp.org/journal/paperinformation.aspx?paperid=123502

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