ProjectCBD presents an annotated history of endocannabinoid discovery
https://www.projectcbd.org/science/endocannabinoid-discovery-timeline
Best of the Week...
In a study of 90 patients with COVID-19, PEA reduced inflammatory states, oxidative states & alterations to blood biomarkers
Effects of Ultramicronized Palmitoylethanolamide (um-PEA) in COVID-19 Early Stages: A Case-Control Study
https://pubmed.ncbi.nlm.nih.gov/35215365/
This study looks at the best combination of CBD & terpenes to reduce the infectivity of COVID-19
Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy
https://pubmed.ncbi.nlm.nih.gov/35242142/
In exercising males, “CBD appears to alter some key physiological and psychological responses to aerobic exercise without impairing performance”
Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial
https://pubmed.ncbi.nlm.nih.gov/35235092/
A review of cannabinoids for bone health & orthopedic effects suggests that CBD is helpful for bone health
Marijuana in Orthopaedics: Effects on Bone Health, Wound-Healing, Surgical Complications, and Pain Management
https://pubmed.ncbi.nlm.nih.gov/35180183/
In a mouse model of acute lung injury, the inhibition of FAAH reversed the inflammation & the histological damage
Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury
https://www.mdpi.com/1422-0067/23/5/2781
In a mouse model of depression, CBD prevented depressive behaviors by modulating the differentiation of neural stem cells into less stressful configurations
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
https://pubmed.ncbi.nlm.nih.gov/35212887/
In a mouse model of Alzheimer’s disease, low doses of THC decreased biomarkers of the disease
Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice
https://www.mdpi.com/1422-0067/23/5/2757/htm
Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)
In men with HIV who used cannabis, they had lower levels of proteins linked to heart disease risk
Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
https://pubmed.ncbi.nlm.nih.gov/33649360/
This study of cancer & pain patients using medical cannabis found a high adherence to following doctors orders, an improved quality if life, a decrease in pain levels & a low incidence of serious adverse events
Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study
https://pubmed.ncbi.nlm.nih.gov/35223923/
This meta-analysis of pediatric patients using cannabinoids finds no significant problems for the GI tract
GASTROINTESTINAL ADVERSE EVENTS OF CANNABINOIDS IN PEDIATRIC POPULATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859120/
Using data from the Releaf app, cannabis found to be quickly effective for nausea – with sativas & higher THC levels performing better
The Effectiveness of Common Cannabis Products for Treatment of Nausea
https://pubmed.ncbi.nlm.nih.gov/35258504/
An analysis of 2-AG levels in women with polycystic ovary syndrome
Analysis of 2-Arachidonoylglycerol Levels in Polycystic Ovary Syndrome in the Context of Hormonal and Metabolic Alterations and Across the Classical Phenotypes
https://pubmed.ncbi.nlm.nih.gov/35235418/
& another study on how their level of anandamide was associated to their waist-to-hip ratio but not their body mass index
Anandamide is associated with waist-to-hip ratio but not with body mass index in women with polycystic ovary syndrome
https://pubmed.ncbi.nlm.nih.gov/35195378/
However, they found no correlation between anandamide levels of healthy volunteers & patients with polycystic ovary syndrome.
Two psychiatrists on what they do when asked about cannabis
The Cannabis Ask: What’s a Psychiatrist to Do?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862599/
Recent Reviews
A review by cannabinoid hero Dr. Donald Abrams on cannabinoids in cancer care
Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care
https://pubmed.ncbi.nlm.nih.gov/35225051/
& a review of CBD for cancer treatment
Cannabidiol and Other Phytocannabinoids as Cancer Therapeutics
https://pubmed.ncbi.nlm.nih.gov/35244889/
This review of 28 studies lists the benefits of cannabinoids for multiple sclerosis
Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination
https://www.mdpi.com/2227-9059/10/3/539
A review of the phytocannabinoids for neuropathic pain
Applications of Cannabinoids in Neuropathic Pain : An updated review
https://www.dl.begellhouse.com/references/3667c4ae6e8fd136,forthcoming,38592.html
A review of cancer pain finds that cannabinoids seem to help opioid painkillers work better
Cannabinoid Association with Opioid in Cancer Pain Management Therapy – A Systematic Review
A review of the effects of age on cannabinoids & cognition suggests that they’re less helpful for teenagers but more helpful for the elderly
Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition
https://pubmed.ncbi.nlm.nih.gov/35209200/
In neuroinflammation, a review of the importance of the ECS & the microglia (often called the guardian cells of the brain)
The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation
https://pubmed.ncbi.nlm.nih.gov/35185547/
This review looks at the effects of THC & CBD on the metabolites of the brain
Effect of cannabinoids on brain metabolites: A review of animal and human studies
https://pubmed.ncbi.nlm.nih.gov/35201831/
A review of the ECS biomarkers for substance use disorder
Biomarkers of the Endocannabinoid System in Substance Use Disorders
https://www.mdpi.com/2218-273X/12/3/396/html
On the use of cannabis by African pharmacists
Medical Use of Cannabis in Africa: The Pharmacists’ Perspective
https://pubs.lib.umn.edu/index.php/innovations/article/view/4430
Preclinical Research & Cannabinoid Chemistry
In a rat model of obesity, CBD treatment protected their hearts via several measures
Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity
https://pubmed.ncbi.nlm.nih.gov/35216351/
In white blood cells infected with HIV, CBD reduced the release of vesicles containing viral loads, perhaps by the reduction of viral transcription & the activation of cellular recycling
Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription
https://pubmed.ncbi.nlm.nih.gov/35203372/
In an animal model of colitis, CBD reduced pain responses
NON-PSYCHOTROPIC PHYTOCANNABINOIDS ATTENUATE VISCERAL HYPERSENSITIVITY IN DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859311/
In a mouse model of kidney disease, the inhibition of the MAGL enzyme lessens scarring & cellular injury
MONOACYLGLYCEROL LIPASE MEDIATES RENAL FIBROSIS THROUGH ENDOGENOUS CANNABINOID SYSTEM
https://www.kireports.org/article/S2468-0249(22)00582-4/pdf
& in a different mouse model of kidney disease, activating the CB2 receptor protected the kidney from scarring
Cannabinoid Type 2 Receptor Activation Reduces the Progression of Kidney Fibrosis Using a Mouse Model of Unilateral Ureteral Obstruction
https://pubmed.ncbi.nlm.nih.gov/35196117/
In 3D models of triple negative breast cancer, CBD caused antitumor effects as well as increasing the effectiveness of the chemotherapy
Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy
https://link.springer.com/article/10.1007/s13346-022-01137-2
In a rat model of pain from chemotherapy, the ability of hyperbaric oxygen treatment to lessen pain & inflammation seems to be mediated by the C2 receptor
Involvement of spinal cannabinoid receptor type 2 in the analgesia effect of hyperbaric oxygen treatment on paclitaxel-induced neuropathic pain
https://pubmed.ncbi.nlm.nih.gov/35226977/
In a mouse model of malaria, THCV seems to be the most helpful cannabinoid for fighting the infection
Evaluation of anti-malarial activity and GC–MS finger printing of cannabis: An in-vivo and in silico approach
In a mouse model of approach & avoidance to fearful stimuli, the ECS worked with the immune system to control inflammation in the amygdala (a central brain hub for emotional processing, especially fear) as well as modulating synaptic plasticity & neuronal metabolism
Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits
https://www.mdpi.com/1422-0067/23/5/2538
In mouse neurons, a look at how the newly discovered cannaflavins might be producing their anti-inflammatory effects
Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B
https://europepmc.org/article/ppr/ppr450972
These researchers are trying to figure out how THC only binds partially to the CB1 receptor because they want to replicate it
Mechanistic Origin of Partial Agonism of Tetrahydrocannabinol for Cannabinoid Receptors