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Research Roundup: Mar 14, 2022



ProjectCBD presents an annotated history of endocannabinoid discovery

https://www.projectcbd.org/science/endocannabinoid-discovery-timeline



Best of the Week...


In a study of 90 patients with COVID-19, PEA reduced inflammatory states, oxidative states & alterations to blood biomarkers

Effects of Ultramicronized Palmitoylethanolamide (um-PEA) in COVID-19 Early Stages: A Case-Control Study

https://pubmed.ncbi.nlm.nih.gov/35215365/


This study looks at the best combination of CBD & terpenes to reduce the infectivity of COVID-19

Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy

https://pubmed.ncbi.nlm.nih.gov/35242142/


In exercising males, “CBD appears to alter some key physiological and psychological responses to aerobic exercise without impairing performance”

Effects of Cannabidiol on Exercise Physiology and Bioenergetics: A Randomised Controlled Pilot Trial

https://pubmed.ncbi.nlm.nih.gov/35235092/


A review of cannabinoids for bone health & orthopedic effects suggests that CBD is helpful for bone health

Marijuana in Orthopaedics: Effects on Bone Health, Wound-Healing, Surgical Complications, and Pain Management

https://pubmed.ncbi.nlm.nih.gov/35180183/


In a mouse model of acute lung injury, the inhibition of FAAH reversed the inflammation & the histological damage

Fatty Acid Amide Hydrolase (FAAH) Inhibition Plays a Key Role in Counteracting Acute Lung Injury

https://www.mdpi.com/1422-0067/23/5/2781


In a mouse model of depression, CBD prevented depressive behaviors by modulating the differentiation of neural stem cells into less stressful configurations

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

https://pubmed.ncbi.nlm.nih.gov/35212887/


In a mouse model of Alzheimer’s disease, low doses of THC decreased biomarkers of the disease

Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice

https://www.mdpi.com/1422-0067/23/5/2757/htm

Clinical Studies & Surveys of CBD & the Endocannabinoid System (ECS)

In men with HIV who used cannabis, they had lower levels of proteins linked to heart disease risk

Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV

https://pubmed.ncbi.nlm.nih.gov/33649360/


This study of cancer & pain patients using medical cannabis found a high adherence to following doctors orders, an improved quality if life, a decrease in pain levels & a low incidence of serious adverse events

Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study

https://pubmed.ncbi.nlm.nih.gov/35223923/


This meta-analysis of pediatric patients using cannabinoids finds no significant problems for the GI tract

GASTROINTESTINAL ADVERSE EVENTS OF CANNABINOIDS IN PEDIATRIC POPULATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859120/


Using data from the Releaf app, cannabis found to be quickly effective for nausea – with sativas & higher THC levels performing better

The Effectiveness of Common Cannabis Products for Treatment of Nausea

https://pubmed.ncbi.nlm.nih.gov/35258504/


An analysis of 2-AG levels in women with polycystic ovary syndrome

Analysis of 2-Arachidonoylglycerol Levels in Polycystic Ovary Syndrome in the Context of Hormonal and Metabolic Alterations and Across the Classical Phenotypes

https://pubmed.ncbi.nlm.nih.gov/35235418/

& another study on how their level of anandamide was associated to their waist-to-hip ratio but not their body mass index

Anandamide is associated with waist-to-hip ratio but not with body mass index in women with polycystic ovary syndrome

https://pubmed.ncbi.nlm.nih.gov/35195378/

However, they found no correlation between anandamide levels of healthy volunteers & patients with polycystic ovary syndrome.


Two psychiatrists on what they do when asked about cannabis

The Cannabis Ask: What’s a Psychiatrist to Do?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862599/



Recent Reviews


A review by cannabinoid hero Dr. Donald Abrams on cannabinoids in cancer care

Cannabis, Cannabinoids and Cannabis-Based Medicines in Cancer Care

https://pubmed.ncbi.nlm.nih.gov/35225051/

& a review of CBD for cancer treatment

Cannabidiol and Other Phytocannabinoids as Cancer Therapeutics

https://pubmed.ncbi.nlm.nih.gov/35244889/


This review of 28 studies lists the benefits of cannabinoids for multiple sclerosis

Neurological Benefits, Clinical Challenges, and Neuropathologic Promise of Medical Marijuana: A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination

https://www.mdpi.com/2227-9059/10/3/539


A review of the phytocannabinoids for neuropathic pain

Applications of Cannabinoids in Neuropathic Pain : An updated review

https://www.dl.begellhouse.com/references/3667c4ae6e8fd136,forthcoming,38592.html


A review of cancer pain finds that cannabinoids seem to help opioid painkillers work better

Cannabinoid Association with Opioid in Cancer Pain Management Therapy – A Systematic Review

https://assets.researchsquare.com/files/rs-1399755/v1/40dab01d-e616-4432-9e61-001dcefd791d.pdf?c=1646254941


A review of the effects of age on cannabinoids & cognition suggests that they’re less helpful for teenagers but more helpful for the elderly

Dos(e)Age: Role of Dose and Age in the Long-Term Effect of Cannabinoids on Cognition

https://pubmed.ncbi.nlm.nih.gov/35209200/


In neuroinflammation, a review of the importance of the ECS & the microglia (often called the guardian cells of the brain)

The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation

https://pubmed.ncbi.nlm.nih.gov/35185547/


This review looks at the effects of THC & CBD on the metabolites of the brain

Effect of cannabinoids on brain metabolites: A review of animal and human studies

https://pubmed.ncbi.nlm.nih.gov/35201831/


A review of the ECS biomarkers for substance use disorder

Biomarkers of the Endocannabinoid System in Substance Use Disorders

https://www.mdpi.com/2218-273X/12/3/396/html


On the use of cannabis by African pharmacists

Medical Use of Cannabis in Africa: The Pharmacists’ Perspective

https://pubs.lib.umn.edu/index.php/innovations/article/view/4430



Preclinical Research & Cannabinoid Chemistry


In a rat model of obesity, CBD treatment protected their hearts via several measures

Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity

https://pubmed.ncbi.nlm.nih.gov/35216351/


In white blood cells infected with HIV, CBD reduced the release of vesicles containing viral loads, perhaps by the reduction of viral transcription & the activation of cellular recycling

Cannabinoids Reduce Extracellular Vesicle Release from HIV-1 Infected Myeloid Cells and Inhibit Viral Transcription

https://pubmed.ncbi.nlm.nih.gov/35203372/


In an animal model of colitis, CBD reduced pain responses

NON-PSYCHOTROPIC PHYTOCANNABINOIDS ATTENUATE VISCERAL HYPERSENSITIVITY IN DEXTRAN SULFATE SODIUM (DSS)-INDUCED COLITIS

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859311/


In a mouse model of kidney disease, the inhibition of the MAGL enzyme lessens scarring & cellular injury

MONOACYLGLYCEROL LIPASE MEDIATES RENAL FIBROSIS THROUGH ENDOGENOUS CANNABINOID SYSTEM

https://www.kireports.org/article/S2468-0249(22)00582-4/pdf

& in a different mouse model of kidney disease, activating the CB2 receptor protected the kidney from scarring

Cannabinoid Type 2 Receptor Activation Reduces the Progression of Kidney Fibrosis Using a Mouse Model of Unilateral Ureteral Obstruction

https://pubmed.ncbi.nlm.nih.gov/35196117/


In 3D models of triple negative breast cancer, CBD caused antitumor effects as well as increasing the effectiveness of the chemotherapy

Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy

https://link.springer.com/article/10.1007/s13346-022-01137-2


In a rat model of pain from chemotherapy, the ability of hyperbaric oxygen treatment to lessen pain & inflammation seems to be mediated by the C2 receptor

Involvement of spinal cannabinoid receptor type 2 in the analgesia effect of hyperbaric oxygen treatment on paclitaxel-induced neuropathic pain

https://pubmed.ncbi.nlm.nih.gov/35226977/


In a mouse model of malaria, THCV seems to be the most helpful cannabinoid for fighting the infection

Evaluation of anti-malarial activity and GC–MS finger printing of cannabis: An in-vivo and in silico approach

https://www.researchgate.net/profile/Nwonuma-Charles/publication/358247488_Evaluation_of_anti-malarial_activity_and_GC-MS_finger_printing_of_cannabis_An_in-vivo_and_in_silico_approach/links/61f82dbfaad5781d41c1542c/Evaluation-of-anti-malarial-activity-and-GC-MS-finger-printing-of-cannabis-An-in-vivo-and-in-silico-approach.pdf


In a mouse model of approach & avoidance to fearful stimuli, the ECS worked with the immune system to control inflammation in the amygdala (a central brain hub for emotional processing, especially fear) as well as modulating synaptic plasticity & neuronal metabolism

Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits

https://www.mdpi.com/1422-0067/23/5/2538


In mouse neurons, a look at how the newly discovered cannaflavins might be producing their anti-inflammatory effects

Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B

https://europepmc.org/article/ppr/ppr450972


These researchers are trying to figure out how THC only binds partially to the CB1 receptor because they want to replicate it

Mechanistic Origin of Partial Agonism of Tetrahydrocannabinol for Cannabinoid Receptors

https://pubmed.ncbi.nlm.nih.gov/35227761/