Research Roundup: June 3, 2025
- Lex Pelger
- Jun 3
- 2 min read
Best of cannabinoid science this week...
In young people with cancer, a survey found they used cannabis to help with nausea, appetite, pain, sadness/anxiety, sleep & to treat the cancer
Pediatric Patient Experiences Using Medical Cannabis in Cancer Symptom Management as Reported by Parents of Children and Adolescents and by Young Adults
In people with cancer treated with immunotherapy, this study of 1,600+ people found cannabis use did not interfere with therapy efficacy
The Impact of Cannabis Use on Patient Outcomes Post Immune Checkpoint Inhibitor Therapy: The DiRECT Cohort
In adolescent chronic pain patients, 25% reported using cannabis for their pain, sleep & anxiety despite these researchers dismissing the evidence of efficacy
Prevalence Rates, Perceptions of Risk, and Motivations for Nonmedical Cannabis Use in Pediatric Pain
In the eyes of saddle horses, CBD significantly reduced their intraocular pressure (relevant to glaucoma)
Effect of Orally Administered Cannabidiol Oil on Daily Tonometric Curve in Healthy Italian Saddle Horses
For children using medical cannabinoids, a living systematic review of 276 studies found the most common indications to be for refractory epilepsy, cancer & cancer symptoms & autism
Cannabinoids for Medical Purposes in Children: A Living Systematic Review
For opioid use disorder & CBD, a systematic review of 20 studies found CBD held promise for reducing cravings, abstinence-induced anxiety & withdrawal symptoms
The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review
For migraines, this literature review found medical cannabis helped reduce their strength & frequency
Efficacy and Safety Study of Medicinal Cannabis in Migraine: a Literature Review
For chronic pain, a systematic review of clinical cannabinoid trials
Cannabis-Based Therapies in Chronic Pain Management: A Systematic Review of Clinical Trials
For the antimicrobial properties of cannabinoids, a systematic review covered 46 papers on its results against resistant pathogens
Exploring Cannabinoids as a Novel Strategy Against Antimicrobial Resistance: A Systematic Review
In a rat model of Parkinson's disease, CBD caused behavioral improvements, normalized markers of oxidative stress & lessened weight loss
Neuroprotective Effects of a Cannabidiol Nanoemulsion in a Rotenone-Induced Rat Model of Parkinson's Disease: Insights into the Gut-Brain Axis
In a rat model of posttraumatic epilepsy (seizures caused by a traumatic brain injury), CBD caused anticonvulsant & neuroprotective effects via the TRPV1 channel
Cannabidiol ameliorates seizures and neuronal damage in ferric chloride-induced posttraumatic epilepsy by targeting TRPV1 channel
In a mouse model of obesity, oleoylethanolamide (the endocannabinoid-like molecule of satiety) reduced body weight, food intake, liver inflammation & fat accumulation in the liver & body as well as improving the gut microbiome & liver health (nice graphical abstract)
Anti-Obesity Effects of Oleoylethanolamide: Modulation of Mitochondrial Bioenergetics, Endocannabinoidome and Gut Microbiome
In a rat model of neuropathic pain, the combination of CBD-rich oil with omega-3 fish oil “effectively prevented thermal and mechanical hypersensitivity, while also improving motor impairment-induced peripheral neuropathy”
Full spectrum cannabis oil combined with omega-3 fish oil for neuropathic pain management: a novel therapeutic approach
In human monocytes (immune cells that release inflammatory factors), THC & CBD caused anti-inflammatory effects
Δ9-Tetrahydrocannabinol and Cannabidiol Selectively Suppress TLR7- and TLR8-Mediated Interleukin-1β Production by Human CD16⁺ Monocytes by Inhibiting Its Post-Translational Maturation
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