Best of cannabinoid science this week...
On the use of CBD by children with cerebral palsy Cannabidiol Use Patterns and Efficacy for Children Who Have Cerebral Palsy https://pubmed.ncbi.nlm.nih.gov/37216564/
In analysis of a caregiver survey for epileptic patients, a substantial proportion reported CBD treatment improved seizure related outcomes Seizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey (P14-1.006) https://n.neurology.org/content/100/17_Supplement_2/2509 And they also reported improvements in outcomes beyond seizure control Nonseizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey (P14-1.008) https://n.neurology.org/content/100/17_Supplement_2/2515 “In pediatric patients, the most common improvements were in the ability to learn new things (76%) and, in nonverbal patients, looking up or smiling at mention of their name (76%). For adult patients, the most common improvement was in alertness (70%).”
In patients with tuberous sclerosis (growth of benign tumors that cause seizures), adding CBD to the standard treatment was well tolerated & produced sustained reductions in seizure levels Long-term Safety and Efficacy of Add-on Cannabidiol (CBD) for Seizures Associated With Tuberous Sclerosis Complex (TSC): 3-Year Results From GWPCARE6 Open-Label Extension (OLE) (P14-1.004) https://n.neurology.org/content/100/17_Supplement_2/2500
In pediatric patients with rare or severe seizure syndromes, the majority saw improvement from CBD therapy Real-world Outcomes of Cannabidiol For The treatment of Refractory Epilepsy in Pediatric Patients (P13-1.011) https://n.neurology.org/content/100/17_Supplement_2/2649
For chronic pain, a guide for dosing the cannabinoids Climbing the Evidence Pyramid: Dosing Considerations for Medical Cannabis in the Management of Chronic Pain https://pubmed.ncbi.nlm.nih.gov/37124080/
For substance use disorders, a review on targeting the endocannabinoid system Targeting the endocannabinoid system in the treatment of addiction disorders https://www.researchgate.net/publication/360685011_Targeting_the_endocannabinoid_system_in_the_treatment_of_addiction_disorders
In a mouse model of depression, CBD caused anti-anxiety & antidepressant effects, worked faster & better than the SSRI sertraline & was better at reducing cognitive impairments & anhedonia than sertraline Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model https://pubmed.ncbi.nlm.nih.gov/37144214/
In immune cells, CBD was stronger at lowering inflammation than THC The Anti-Inflammatory Effects of Cannabis Sativa Extracts on LPS-Induced Cytokines Release in Immune and Non-Immune Cells in Vitro https://www.preprints.org/manuscript/202305.1512/v1
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