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Research Roundup: June 13, 2023



Best of cannabinoid science this week...


On the use of CBD by children with cerebral palsy Cannabidiol Use Patterns and Efficacy for Children Who Have Cerebral Palsy https://pubmed.ncbi.nlm.nih.gov/37216564/


In analysis of a caregiver survey for epileptic patients, a substantial proportion reported CBD treatment improved seizure related outcomes Seizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey (P14-1.006) https://n.neurology.org/content/100/17_Supplement_2/2509 And they also reported improvements in outcomes beyond seizure control Nonseizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey (P14-1.008) https://n.neurology.org/content/100/17_Supplement_2/2515 “In pediatric patients, the most common improvements were in the ability to learn new things (76%) and, in nonverbal patients, looking up or smiling at mention of their name (76%). For adult patients, the most common improvement was in alertness (70%).”


In patients with tuberous sclerosis (growth of benign tumors that cause seizures), adding CBD to the standard treatment was well tolerated & produced sustained reductions in seizure levels Long-term Safety and Efficacy of Add-on Cannabidiol (CBD) for Seizures Associated With Tuberous Sclerosis Complex (TSC): 3-Year Results From GWPCARE6 Open-Label Extension (OLE) (P14-1.004) https://n.neurology.org/content/100/17_Supplement_2/2500


In pediatric patients with rare or severe seizure syndromes, the majority saw improvement from CBD therapy Real-world Outcomes of Cannabidiol For The treatment of Refractory Epilepsy in Pediatric Patients (P13-1.011) https://n.neurology.org/content/100/17_Supplement_2/2649


For chronic pain, a guide for dosing the cannabinoids Climbing the Evidence Pyramid: Dosing Considerations for Medical Cannabis in the Management of Chronic Pain https://pubmed.ncbi.nlm.nih.gov/37124080/


For substance use disorders, a review on targeting the endocannabinoid system Targeting the endocannabinoid system in the treatment of addiction disorders https://www.researchgate.net/publication/360685011_Targeting_the_endocannabinoid_system_in_the_treatment_of_addiction_disorders


In a mouse model of depression, CBD caused anti-anxiety & antidepressant effects, worked faster & better than the SSRI sertraline & was better at reducing cognitive impairments & anhedonia than sertraline Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model https://pubmed.ncbi.nlm.nih.gov/37144214/


In immune cells, CBD was stronger at lowering inflammation than THC The Anti-Inflammatory Effects of Cannabis Sativa Extracts on LPS-Induced Cytokines Release in Immune and Non-Immune Cells in Vitro https://www.preprints.org/manuscript/202305.1512/v1

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