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Research Roundup: July 4, 2022

Best of cannabinoid science this week...

In humans with acute mania being treated with lithium & risperidone, 600 mg of PEA caused a significantly lower score on the Young Mania Rating Scale Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: a randomized, double-blind and placebo-controlled trial

This thorough review of autism spectrum disorders looks at the overlap between the endocannabinoid system & the microbiome’s effect on the gut-brain axis The Endocannabinoids-Microbiota Partnership in Gut-Brain Axis Homeostasis: Implications for Autism Spectrum Disorders

In rats with a vitamin D3 deficiency, CBD improved their thyroid function & increased the levels of Vitamin D receptor as well as vitamin D3 levels, suggesting it as a treatment for people with low functioning thyroids as well as to maintain bone health Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model In skin stem cells, CBD has a central role in inhibiting pro-inflammatory signals Cannabidiol has a central role in the NF-κB inhibition of a Cannabis sativa L. extract in human keratinocytes In a test of various vegetable oils, olive oil best helped to increase CBD absorption Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol Also, remember that in general, it is better to take your CBD after a meal with a little bit of fat in it. Lipids like to stick together & this helps to increase absorption.

A review of cannabis for autoimmune disorders Cannabis and Autoimmune Diseases A review of how the endocannabinoid system balances the intestines The role of the endocannabinoid system in the regulation of intestinal homeostasis


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