Best of cannabinoid science this week...
In humans with acute mania being treated with lithium & risperidone, 600 mg of PEA caused a significantly lower score on the Young Mania Rating Scale Efficacy and safety of palmitoylethanolamide as an adjunctive treatment for acute mania: a randomized, double-blind and placebo-controlled trial https://pubmed.ncbi.nlm.nih.gov/35737597
This thorough review of autism spectrum disorders looks at the overlap between the endocannabinoid system & the microbiome’s effect on the gut-brain axis The Endocannabinoids-Microbiota Partnership in Gut-Brain Axis Homeostasis: Implications for Autism Spectrum Disorders https://pubmed.ncbi.nlm.nih.gov/35721203
In rats with a vitamin D3 deficiency, CBD improved their thyroid function & increased the levels of Vitamin D receptor as well as vitamin D3 levels, suggesting it as a treatment for people with low functioning thyroids as well as to maintain bone health Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model https://link.springer.com/article/10.1007/s13197-022-05492-3 In skin stem cells, CBD has a central role in inhibiting pro-inflammatory signals Cannabidiol has a central role in the NF-κB inhibition of a Cannabis sativa L. extract in human keratinocytes https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0042-1749286 In a test of various vegetable oils, olive oil best helped to increase CBD absorption Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol https://pubmed.ncbi.nlm.nih.gov/35753538 Also, remember that in general, it is better to take your CBD after a meal with a little bit of fat in it. Lipids like to stick together & this helps to increase absorption.
A review of cannabis for autoimmune disorders Cannabis and Autoimmune Diseases https://pubmed.ncbi.nlm.nih.gov/35734843 A review of how the endocannabinoid system balances the intestines The role of the endocannabinoid system in the regulation of intestinal homeostasis https://pubmed.ncbi.nlm.nih.gov/35750314