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Research Roundup: July 26, 2021

Best of the Week...

A new study from CV Sciences shows CBD reducing nicotine withdrawal symptoms in rats

Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats

CV Sciences medical adviser Dr. Jamie Corroon publishes a primer for clinicians on using topical CBD for pain

Topical CBD for Pain: A primer for clinicians

In a rat model of neuropathic pain, CBD helped on several different measures of pain & anxiety

Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors

In a rodent model of depression, CBD prevented “both behavioral & neuro-immunological changes associated” with depression as well as modulating neuroinflammation

Cannabidiol prevents lipopolysaccharide-induced sickness behavior and alters cytokine and neurotrophic factor levels in the brain

In rats with nerve injuries, CBD helped with pain & symptoms of depression via the serotonin receptors & CB1 receptors

Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial prefrontal cortex 5-HT 1A and CB 1 receptors

In mice, CBD helped to reduce binge eating behavior

Cannabidiol reduces binge eating behavior in mice

In rats addicted to methamphetamine, CBD protected the brain from damage

Cannabidiol Modulates the Expression of Neurotrophin Signaling Pathway in Chronic Exposure Methamphetamine Rats During Abstinence Period

In a mouse model of post-surgical pain, β-Caryophyllene (the terpene most often found in the hemp plant) inhibited the MAGL enzyme & thus increased 2-AG levels to help treat the pain

β-Caryophyllene inhibits monoacylglycerol lipase activity and increases 2-AG levels: a new mechanism of endocannabinoid-mediated analgesia?

β-Caryophyllene is often referred to as a dietary cannabinoid because it activates the CB2 receptor all by itself. It was the first ligand of a cannabinoid receptor to come from the plant that was fundamentally different from the classic cannabinoid structure.

Clinical Studies & Reviews of CBD & the Endocannabinoid System (ECS)

In humans, a test of CBD for pain found it safe & well-tolerated

The dose-dependent analgesic effects, abuse liability, safety and tolerability of oral cannabidiol in healthy humans

In humans with PTSD, the ability of exercise to help reduce threat expectancy is mediated via anandamide & BDNF (an important brain growth factor regulated by the ECS)

Exercise-induced increases in Anandamide and BDNF during extinction consolidation contribute to reduced threat following reinstatement: Preliminary evidence from a randomized controlled trial

A review of why the cannabinoids can be helpful for the neurological consequences of HIV

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

In humans with Hermansky–Pudlak syndrome (a rare genetic disorder leading to fatal adult scarring of the heart), treatment with MRI-1867 (a dual inhibitor of the CB1 receptor & enzyme that creates the signaling molecule nitric oxide) prevented heart scarring & revered dysfunction of the mitochondria (the powerhouse of the cell)

CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Preclinical Research & Cannabinoid Chemistry

In mice, CBD helped to modulate the addictive effects of the psychostimulant MDPV

Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice

A new screening of THC & CBD against the CYP liver enzymes responsible for drug metabolism

Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization

In rats with depression from traumatic nerve pain, the injury seems to lower the levels of cannabinoids & lead to behavioral depression

Dynamic Change of Endocannabinoid Signaling in the Medial Prefrontal Cortex Controls the Development of Depression after Neuropathic Pain

In rats, activating the CB2 receptor helped to protect against uterine damage

The Activation of Cannabinoid Type-2 Receptor with JWH-133 Protects Uterine Ischemia/Reperfusion-Induced Damage

In a rat model of glaucoma, activating the cannabinoid receptors protected the neurons associated with vision

VSN16S, an agonist of the cannabinoid receptor, reduces IOP profiles and exhibits neuroprotective properties in a rat model of glaucoma

In a cellular model of diabetic retinopathy (damage to the blood vessels at the back of the eye), activating the CB2 receptor decreased inflammation

Cannabinoid Receptor 2 Agonist HU-308 Demonstrates Therapeutic Potential in Inflammatory Diabetic Retinopathy Models

In mice, the brain’s medium spiny neurons – which contain the highest levels of CB1 receptors in the CNS – control exploration & motor coordination partially via the ECS

Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB 1 receptors expressed in medium spiny neurons

In a rat’s aorta, the drug affinin (a painkiller with a structure similar to anandamide) appears to act via the CB1, TRPV1 & TRPA1 receptors to cause vasodilation in the heart

Endothelial TRP channels and cannabinoid receptors are involved in affinin-induced vasodilation


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