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Research Roundup: July 18, 2022



Best of cannabinoid science this week...


An article on GABA & the ECS https://www.projectcbd.org/taking-it-slow-gaba

A study in former professional football players found that hemp extracts may help with cognitive performance & emotional processing Automated Detection of Cognitive Performance and Resilience Changes in Former Professional American Football Players Following the Administration of a Hemp Extract https://www.neuroregulation.org/article/view/22585 In a test of female athletes who used cannabis regularly, while there was no difference in body size, body composition, pulmonary function, cardiorespiratory function, or muscular strength, they produced less power in a laboratory fitness test but also experienced significantly less anaerobic fatigue Regular Use of Cannabis in Female Athletes Is Associated With a Reduction in Early Anaerobic Power Production https://journals.lww.com/nsca-jscr/Fulltext/9900/Regular_Use_of_Cannabis_in_Female_Athletes_Is.47.aspx For cancer patients, cannabis helped them with pain & to use fewer opioids Experience With Medical Marijuana for Cancer Patients in the Palliative Setting https://www.cureus.com/articles/102316-experience-with-medical-marijuana-for-cancer-patients-in-the-palliative-setting A review of kids using artisanal CBD oil for their epilepsy showed it to be effective & safe The long-term effectiveness and safety of cannabidiol-enriched oil in children with drug-resistant epilepsy https://www.sciencedirect.com/science/article/abs/pii/S0887899422001229 In general, studies have shown that full spectrum extracts work better for pediatric epilepsy than isolated CBD alone. In patients with early psychosis, one dose of CBD lowered activity in the insula (a brain region associated with motivation & sensory processing) Cannabidiol attenuates insular activity during motivational salience processing in patients with early psychosis https://pubmed.ncbi.nlm.nih.gov/35775365 In humans with X-linked adrenoleukodystrophy (a rare genetic condition that damages the myelin sheaths of your nerve cells as well as your adrenal glands), they had higher levels of CB2 receptors & activating those CB2 receptors improved the metabolic problems underlying the disease & helped with oxidative stress Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy https://pubmed.ncbi.nlm.nih.gov/35778568 One of the most notable aspects of the cannabinoids is how often they help with rare disorders where we have few options. The ubiquity of the endocannabinoid system speaks to its power to heal. In lung cells, full-spectrum CBD-rich extracts are more potent that isolates & they recommend a cannabinoid mouth wash as a barrier to entry Crude Cannabis Extracts are More Potent than Mono- Substances in Inhibiting SARS-CoV-2 Entry https://biomedres.us/fulltexts/BJSTR.MS.ID.007030.php In a mouse model of Parkinson’s disease, CBD improved cognitive dysfunction & increased locomotion, decreased neuroinflammation & protected the dopamine producing neurons Cannabidiol Alleviates the Damage to Dopaminergic Neurons in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease Mice Via Regulating Neuronal Apoptosis and Neuroinflammation https://pubmed.ncbi.nlm.nih.gov/35792194 In humans, drinking alcohol lowered the levels of anandamide in their blood The effects of acute alcohol administration on circulating endocannabinoid levels in humans https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13197