Best of cannabinoid science this week...
In neuropathic pain from diabetes, adding PEA to standard therapy caused significant reductions in pain, enhanced sensitivity & better quality of life
Assessing the Effectiveness of Add-On Therapy of Palmitoylethanolamide to Standard Therapy in Diabetic Peripheral Neuropathy
In dogs with osteoarthritis, 30 days of a full-plant extract CBD oil significantly reduced pain & improved quality of life with anti-inflammatory & antioxidant effects
Effects of a Cannabinoid-Based Phytocomplex (Pain ReliefTM) on Chronic Pain in Osteoarthritic Dogs
For musculoskeletal pain, a review of 13 papers found cannabis “associated with significant pain reduction, improved motor function, enhanced sleep quality, and overall improvements in health-related quality of life”
Medical cannabis in the management of musculoskeletal pain: a systematic review of clinical trials
For Parkinson's disease, a review of cannabis use indicated “that cannabis can mitigate levodopa-induced dyskinesias and improve overall quality of life in patients”
Effects of Cannabis in Parkinson's Disease and Other Movement Disorders
“Neuroprotective properties, such as reducing oxidative stress and neuroinflammation, have been demonstrated, suggesting potential benefits in slowing disease progression.”
For CBD & the 5-HT1A serotonin receptor, a review of their interactions & the “antidepressant, anxiolytic, neuroprotective, antipsychotic, antiemetic, anti-allodynic, anti-epileptic, anti-degenerative, and addiction-treating properties”
CBD and the 5-HT1A receptor: A medicinal and pharmacological review
For pain, a review of using cannabis
Cannabis and Pain Management
For substance use disorders, a book chapter on using the cannabinoids
Phyto, Synthetic, and Endogenous Cannabinoids as Theoretical Possibilities of Therapeutic Molecules for the Treatment of Addictions
And for substance use disorders, a book chapter on the interplay between cannabinoid receptors & and nicotinic acetylcholine receptors
Nicotinic Acetylcholine Receptors, Cannabinoid Receptors, and Their Interplay in Drug Addiction
For arthritis, a review of using terpenes
Terpenes and Terpene Based Nanoformulations: A New Prospect for Arthritis Management
In a rat model of sleep deprivation, CBD caused a “remarkable” restoration of the kidneys & liver
Modulatory role of cannabidiol and sleep recovery on hepato-renal functions and histological alterations triggered by sleep deprivation in adult male Wistar rats
In a mouse model of ulcerative colitis, CBD lessened the intestinal fibrosis [scarring], inflammation & oxidative stress via the Nrf2 signaling pathway
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway
In pathogenic oral bacteria, CBD caused antibacterial & antibiofilm activity
antibacterial and antibiofilm role of cannabidiol against periodontopathogenic bacteria
In a rat model of acute lung injury, the terpene beta-caryophyllene “dramatically reduced lung edema [excess fluid], vascular permeability, and histological changes” & lessened oxidative stress & inflammation via ACE2/MasR & Nrf2/HO-1/NF-κB
β‐Caryophyllene attenuates oxidative stress and inflammatory response in LPS induced acute lung injury by targeting ACE2/MasR and Nrf2/HO-1/NF-κB axis
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