Best of cannabinoid science this week...
In healthy adults, 300 mg of isolated CBD caused no performance impairments in various cognitive & psychomotor functions but might affect certain aspects of vigilance The effects of cannabidiol on subjective states, cognition, and psychomotor function in healthy adults: A randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/36625844/
A review of treating skin diseases with cannabinoids
Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases
A review of using CBD against fragile X syndrome (a genetic developmental disorder that causes intellectual disability) Role of the endocannabinoid system in fragile X syndrome: potential mechanisms for benefit from cannabidiol treatment https://pubmed.ncbi.nlm.nih.gov/36624400/
CBD as a strong antibiotic against the bacteria that cause cavities Anti-Bacterial Effect of Cannabidiol against the Cariogenic Streptococcus mutans Bacterium: An In Vitro Study https://pubmed.ncbi.nlm.nih.gov/36555519/
In a rat model of pulmonary hypertension, CBD lowered the proliferation of negative cells & decreased the release of inflammatory cytokines Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats https://pubmed.ncbi.nlm.nih.gov/36634588/
In a mouse model of inflammatory pain, combining CBD & β-caryophyllene (a common cannabis terpene) to produce synergistic painkilling effects via control of inflammation Cannabidiol and Beta-Caryophyllene in Combination: A Therapeutic Functional Interaction https://pubmed.ncbi.nlm.nih.gov/36555111/
In a mouse model of epilepsy, CBD helped lower seizures, lessen inflammation & reduce neuropathic pain EVALUATION OF THERAPEUTIC POTENTIAL OF CANNABIDIOLBASED PRODUCTS IN ANIMAL MODELS OF EPILEPTIC SEIZURES, NEUROPATHIC PAIN AND CHRONIC INFLAMMATION https://farmaciajournal.com/wp-content/uploads/art-24-Blebea_Mihai_Negres_1185-1193.pdf
CBD nano topicals applied to the eyes of rabbits lowered intraocular pressure Cannabidiol Loaded Topical Ophthalmic Nanoemulsion Lowers Intraocular Pressure in Normotensive Dutch-Belted Rabbits https://pubmed.ncbi.nlm.nih.gov/36559077/
A study in horses finds that CBD has an oral bioavailability close to 14% & no noted adverse effects Pharmacokinetics and oral bioavailability of cannabidiol in horses after intravenous and oral administration with oil and micellar formulations https://pubmed.ncbi.nlm.nih.gov/36624043/ plus a small CBD safety study in mature horses confirms no negative effects on liver & kidney function Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability and Performance in Mature Horses https://www.mdpi.com/2076-2615/13/2/245