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Research Roundup: Feb 28, 2023



Best of cannabinoid science this week...


In an MRI scans of aging brains, inhaling CBD caused increased network connectivity while inhaled THC appeared to be a helpful painkiller

Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study


For a 3 year old dog with intense jaw pain from a nerve sheath tumor, using CBD oil & gabapentin to relieve the pain Cannabinoid oil with gabapentin for the treatment of chronic neuropathic pain – case repor https://www.researchgate.net/publication/367537234_Cannabinoid_oil_with_gabapentin_for_the_treatment_of_chronic_neuropathic_pain_-_case_report


A review of the studies on CBD's effect on innate immunity

Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance


A review of the antiviral effects of the cannabinoids

Cannabis as antivirals


A review of the antiviral effects of the cannabinoids

Cannabis as antivirals


In a rat model of endometriosis, CBD caused significant anti-inflammatory & antioxidative effects Cannabidiol as a potential novel treatment for endometriosis by its anti-inflammatory, antioxidative and anti-angiogenic effects in an experimental rat model https://www.rbmojournal.com/article/S1472-6483(23)00056-1/fulltext


In a mouse model of neuropathic pain, CBD combined well with electric nerve stimulation of this skin to reduce pain, possibly via a spinal increase of the anti-inflammatory cytokine IL-10 Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice https://pubmed.ncbi.nlm.nih.gov/36719831/


In astrocytes (key brain support cells), CBD lowered damage in a model of neurodegeneration via several pathways Effect of Cannabidiol in LPS-induced toxicity in astrocytes: Possible role for cannabinoid type-1 receptors https://europepmc.org/article/ppr/ppr610649


In a mouse model of multiple sclerosis, CBD lowered the recruitment of white blood cells going to the spinal cord Cannabidiol Attenuates In Vivo Leukocyte Recruitment to the Spinal Cord Microvasculature at Peak Disease of Experimental Autoimmune Encephalomyelitis https://pubmed.ncbi.nlm.nih.gov/36745386/


In a mouse model of seizures, while PEA did not reduce the seizures, it did increase the effectiveness of the drug ganaxolone & reduced mortality Investigating the synergistic effect of palmitoylethanolamide and ganaxolone in PTZ-induced tonic-clonic seizures http://sjku.muk.ac.ir/browse.php?a_id=6998&sid=1&slc_lang=en


In a model of human mouth diseases & dental implants, CBD & CBG helped with inflammation The immunomodulatory role of phytocannabinoids in an in vitro peri-implantitis model https://scholar.kyobobook.co.kr/article/detail/4050037055638


In a mouse model of inflammatory bowel disease, protein nanoparticles loaded with CBD lessened intestinal inflammation, probably via the CB2 receptor P037 Enhancing the efficacy of cannabidiol using protein nanoparticles to treat inflammatory bowel disease https://academic.oup.com/ecco-jcc/article/17/Supplement_1/i204/7009419


On human keratinocytes (skin stem cells), CBG, CBC, THCV & CBDA all reduced inflammation via the reduction of proinflammatory cytokines, perhaps mediated by the TRPV1 receptor & the MAGL enzyme Rare Phytocannabinoids Exert Anti-Inflammatory Effects on Human Keratinocytes via the Endocannabinoid System and MAPK Signaling Pathway https://pubmed.ncbi.nlm.nih.gov/36769042/


In calves being transported or weaned, CBD lowered their measures of stress hormones EFFECTS OF CANN S OF CANNABINOID SUPPLEMEN ABINOID SUPPLEMENTATION ON WEANING TION ON WEANING AND TRANSPORTATION STRESS IN BEEF CALVES https://digitalcommons.murraystate.edu/cgi/viewcontent.cgi?article=1312&context=etd

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