Best of cannabinoid science this week...
For menstrual pain, 300 milligrams of PEA significantly reduced acute menstrual pain scores
Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, double-blind, placebo-controlled trial
In women with problems during their menstrual cycle, cannabis use was more frequent during the premenstrual phase & was used to manage physical pain & discomfort as well as dealing with depression
Cannabis use across the menstrual cycle: The impact of negative affect and cannabis use motives
In people with breast cancer, a survey said they used CBD for pain, anxiety & insomnia
Characterizing Cannabidiol Use in a Breast Cancer Population
For cancer pain from the UK Medical Cannabis Registry, a case series with medical cannabis showed improved sleep & reduced pain & anxiety
UK Medical Cannabis Registry: An Analysis of Clinical Outcomes of Medicinal Cannabis Therapy for Cancer Pain
For pediatric conditions, a review of 111 found evidence for severe seizure disorders, chemotherapy-induced nausea & vomiting, Fragile X syndrome, fetal alcohol syndrome, PTSD, autism & some gut disorders
Medicinal Cannabinoids in Children: A Scoping Review
On CBD for anxiety, a review of the double-blind trials
A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders
For pediatric conditions, a review of 111 found evidence for severe seizure disorders, chemotherapy-induced nausea & vomiting, Fragile X syndrome, fetal alcohol syndrome, PTSD, autism & some gut disorders
Medicinal Cannabinoids in Children: A Scoping Review
On CBD for anxiety, a review of the double-blind trials
A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders
“Positive outcomes were observed with 300 mg CBD doses, reducing anxiety in SAD [social anxiety disorder] patients, tremor in Parkinson’s disease, and anxiety in ASD [autism spectrum disorder] and opioid-dependent individuals.”
For amyotrophic lateral sclerosis, a review of the benefits & mechanisms of cannabinoids
Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications
In neuropathic pain, a review exploring the interplay between the ECS & autophagy (cellular recycling)
Cannabinoids as Potential Multitargeting Neuroprotectants in Neuropathic Pain: Exploring the Interplay between Cannabinoid System and Autophagy
And for chronic pain, a review of the efficacy of the cannabinoids
The Pharmacology of Cannabinoids in Chronic Pain The Pharmacology of Cannabinoids in Chronic Pain
A review of CBD’s benefits (good charts)
Cannabidiol - a friend or a foe?
And a review of cannabinoids for certain diseases (good charts on medical, cancer & antiviral effects)
Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases
For the guts, a review of how the endocannabinoids regulate their function & pathology (good charts!)
The Endocannabinoid System: Implications in Gastrointestinal Physiology and Pathology
For beta caryophyllene & inflammation, a review of its activity & mechanisms
A Mechanistic Review on the Anti-inflammatory Effects of β-caryophyllene
In dogs with atopic dermatitis (eczema), a review of the efficacy of CBD
The Potential of Cannabidiol for Treating Canine Atopic Dermatitis
In a rat model of autism, CBD nanoemulsions reversed autistic-like behaviors & protected from neuronal death in the hippocampus (memory center of the brain)
Nanoemulsions with cannabidiol reduced autistic-like behaviors and reversed decreased hippocampus viable cells and cerebral cortex neuronal death in a prenatal valproic acid rat model
In a rat model of traumatic brain injury, CBD improved neurological deficits & lessened neuronal damage, neuroinflammation & reduced blood-brain barrier permeability
Cannabidiol alleviates the inflammatory response in rats with traumatic brain injury through the PGE2-EP2-cAMP-PKA signaling pathway
In a rat model of orofacial pain, CBD increased the painkilling effects of opioids
Cannabidiol interactions with oxycodone analgesia in an operant orofacial cutaneous thermal pain assay following oral administration in rats
In a mouse model of neuropathic pain, cannabis oil reduced pain sensitivity & improved recovery
Moroccan Cannabis sativa essential oil attenuates peripheral neuropathic pain induced by chronic sciatic nerve constriction injury in mice
In a rat model of neuropathic pain, cannabis lowered hypersensitivity to pain & susceptibility to mechanical pain via the CB2 receptor & the regulation of genetic transcription
The cannabinoid CB2 receptor mediates the analgesic effects of Cannabis sativa extract in a rat model of neuropathic pain
In a rat model of blunt chest trauma, CBD reduced inflammation, lung damage & apoptosis (at programmed cellular suicide)
Cannabidiol protects lung against inflammation and apoptosis in a rat model of blunt chest trauma via Bax/Bcl-2/Cas-9 signaling pathway
In the oral cavity, a thesis project on how CBD & CBG modulated the biofilms of oral bacteria & immune responses
Antibiofilm and Immune-Modulatory Activity of Cannabidiol and Cannabigerol in Oral Environments—In Vitro Study
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