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Research Roundup: Dec 19, 2023



Best of cannabinoid science this week...


A survey of Finnish chronic pain patients found that they perceived opioids to be as effective as medical cannabis in reducing pain intensity, but cannabis was also more helpful for emotion, functionality & overall sense of well-being

The holistic effects of medical cannabis compared to opioids on pain experience in Finnish patients with chronic pain

 

In people with refractory cancer related pain, most found cannabis to give pain relief as well as help with sleep & anorexia

Medical cannabis for refractory cancer-related pain in a specialised clinical service: a cross-sectional study

And a thesis project on Canadian cancer survivors using cannabis for sleep

CANADIAN CANCER SURVIVORS’ USE OF CANNABIS AS A SLEEP AID


In a survey of people on self-reported stress, both a CBD isolate of 1000 milligrams & a broad spectrum product of 1000 milligrams had the ability to reduce stress, with the broad-spectrum getting endorsed as more effective (data from the Releaf app)

Effects of Two Cannabidiol Oil Products on Self-Reported Stress Relief: A Quasi-Experimental Study


For spine surgery, a review on the use of cannabinoids for pain relief & recovery

Unlocking the Healing Potential: Cannabinoids in Spine Surgery for Pain Relief and Recovery


In a rat model of chronic moderate exercise, they had increased cannabinoid receptor expression on certain immune cells, suggesting a higher reactivity & efficiency from the immune system

Impact of Chronic Moderate Exercise on Immune Cells and Cytokine Levels in Rats: Focus on the Endocannabinergic Pathway

 

In a rat model of seizures, CBD significantly reduced their seizure duration & lowered inflammatory cytokines via the CB1 receptor, but not via the CB2 or GABAA receptors

Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and Cannabinoids 1 (CB1), But Not CB2 and GABAA Receptors

 

In a rat model of obesity, THC caused an anti-inflammatory effect in their fat tissue as well as significant weight loss

Anti-Inflammatory Effects of ∆9 Tetrahydrocannabinol in Adipose Tissue of an Obese Rat Model


In rats with chronic sleep deprivation, anandamide lowered the neurobehavioral deficits & brain wave irregularities via the lowering of neuroinflammation & oxidative stress

Anandamide Attenuates Neurobehavioral Deficits and EEG Irregularities in the Chronic Sleep Deprivation Rats: The Role of Oxidative Stress and Neuroinflammation


In a rat model of neuropathic pain, a drug that inhibits the FAAH enzyme prevented the development of mechanical allodynia (pain due to a stimulus that does not normally provoke pain)

URB937 Prevents the Development of Mechanical Allodynia in Male Rats with Trigeminal Neuralgia

 

A thesis project on migraine pain & the anti-nociceptive effects of the endocannabinoids

PRO-NOCICEPTIVE ROLE OF PIEZO1 CHANNELS AND THE ANTI-NOCICEPTIVE EFFECTS OF ENDOCANNABINOIDS IN THE TRIGEMINAL SYSTEM IMPLICATED IN MIGRAINE PAIN

 

In a zebrafish model of pain, on the use of CBD & CBG as analgesics

Verification of the analgesic properties of natural compounds of cannabinoid origin in Danio rerio model of nociception


In a mouse model of the primary toxin from amanita, CBD protected the liver, lowered apoptosis (cellular suicide) & increased survival rates via regulation of Nrf2

Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2

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