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Research Roundup: Aug 22, 2022

Best of cannabinoid science this week...

In patients with cancer, 300 mg of CBD per day lessened their chemotherapy-induced peripheral neuropathy (nerve pain in the body) Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy

For people with autism in the UK Medical Cannabis Registry, they saw “significant improvements in general health-related quality of life and sleep” Clinical Outcome Analysis of Patients with Autism Spectrum Disorder – Analysis from the UK Medical Cannabis Registry And a review of using CBD to treat autism Cannabidiol for the treatment of autism spectrum disorder: hope or hype?

A review of the studies on using CBD & THC for anxiety Medicinal cannabis for the treatment of anxiety disorders

In certain brain regions of rats, CBD increases BDNF (a brain growth factor) Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network

In mice undergoing exhaustive exercise, CBD reduced rupture of the heart tissue, the degree of inflammatory cell infiltration & the deposition of collagen fibers in the heart tissue, perhaps via activation of the Keap1/Nrf2/HO-1 signaling pathway Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice

In human immune & cardiac cells exposed to an inflammatory agent (a model of sepsis leading to cardiac arrhythmias), CBD protected against the inflammation & arrhythmias via inhibition of inflammatory cytokine release, antioxidant & anti-apoptotic effects (cellular suicide) & via the cardiac sodium channels Anti-inflammatory effects of cannabidiol against lipopolysaccharides in cardiac sodium channels

In dogs, how CBD & CBDA moves through their system Twenty-Four Hour and One-Week Steady State Pharmacokinetics of Cannabinoids in Two Formulations of Cannabidiol and Cannabidiolic Acid Rich Hemp in Dogs

How CBD moves through the body of an Amazonian parrot Pharmacokinetics of Cannabidiol in the Hispaniolan Amazon Parrot ( Amazona ventralis)

A great review on how the endocannabinoids alter synaptic function Endocannabinoid signaling in synaptic function

2021: A review of the effects of cannabis on your proteome – all of the proteins in your body A Proteomic View of Cellular and Molecular Effects of Cannabis

A 3D printed CBD/CBG gel for wound healing Fabrication and Preliminary In Vitro Evaluation of 3D-Printed Alginate Films with Cannabidiol (CBD) and Cannabigerol (CBG) Nanoparticles for Potential Wound-Healing Applications

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