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Research Roundup: Aug 22, 2022



Best of cannabinoid science this week...


In patients with cancer, 300 mg of CBD per day lessened their chemotherapy-induced peripheral neuropathy (nerve pain in the body) Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy https://pubmed.ncbi.nlm.nih.gov/35933415


For people with autism in the UK Medical Cannabis Registry, they saw “significant improvements in general health-related quality of life and sleep” Clinical Outcome Analysis of Patients with Autism Spectrum Disorder – Analysis from the UK Medical Cannabis Registry https://kclpure.kcl.ac.uk/portal/en/publications/clinical-outcome-analysis-of-patients-with-autism-spectrum-disorder--analysis-from-the-uk-medical-cannabis-registry(1fb2fe2d-ea46-4f78-9b42-b426455bbf63).html And a review of using CBD to treat autism Cannabidiol for the treatment of autism spectrum disorder: hope or hype? https://pubmed.ncbi.nlm.nih.gov/35904579


A review of the studies on using CBD & THC for anxiety Medicinal cannabis for the treatment of anxiety disorders https://pubmed.ncbi.nlm.nih.gov/35908759


In certain brain regions of rats, CBD increases BDNF (a brain growth factor) Single and Repeated Exposure to Cannabidiol Differently Modulate BDNF Expression and Signaling in the Cortico-Striatal Brain Network https://www.mdpi.com/2227-9059/10/8/1853/htm


In mice undergoing exhaustive exercise, CBD reduced rupture of the heart tissue, the degree of inflammatory cell infiltration & the deposition of collagen fibers in the heart tissue, perhaps via activation of the Keap1/Nrf2/HO-1 signaling pathway Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice https://pubmed.ncbi.nlm.nih.gov/35926578


In human immune & cardiac cells exposed to an inflammatory agent (a model of sepsis leading to cardiac arrhythmias), CBD protected against the inflammation & arrhythmias via inhibition of inflammatory cytokine release, antioxidant & anti-apoptotic effects (cellular suicide) & via the cardiac sodium channels Anti-inflammatory effects of cannabidiol against lipopolysaccharides in cardiac sodium channels https://pubmed.ncbi.nlm.nih.gov/35906756


In dogs, how CBD & CBDA moves through their system Twenty-Four Hour and One-Week Steady State Pharmacokinetics of Cannabinoids in Two Formulations of Cannabidiol and Cannabidiolic Acid Rich Hemp in Dogs https://esmed.org/MRA/mra/article/view/2907


How CBD moves through the body of an Amazonian parrot Pharmacokinetics of Cannabidiol in the Hispaniolan Amazon Parrot ( Amazona ventralis) https://pubmed.ncbi.nlm.nih.gov/35972864


A great review on how the endocannabinoids alter synaptic function Endocannabinoid signaling in synaptic function https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.24256


2021: A review of the effects of cannabis on your proteome – all of the proteins in your body A Proteomic View of Cellular and Molecular Effects of Cannabis https://pubmed.ncbi.nlm.nih.gov/34680044


A 3D printed CBD/CBG gel for wound healing Fabrication and Preliminary In Vitro Evaluation of 3D-Printed Alginate Films with Cannabidiol (CBD) and Cannabigerol (CBG) Nanoparticles for Potential Wound-Healing Applications https://www.mdpi.com/1999-4923/14/8/1637